Trial reportArthritis research & therapy2015
Experimental knee pain impairs submaximal force steadiness in isometric, eccentric, and concentric muscle actions.
Trial report in Arthritis research & therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Does pain influence control of muscle force? A systematic review and meta-analysis.European journal of pain (London, England) · 2025Pooled it
- Reduced knee extensor torque steadiness and increased motor unit discharge rate variability in young people with patellofemoral pain: a pilot study.European journal of applied physiology · 2026Article
- Individuals With Chronic Ankle Instability Show Abnormalities in Maximal and Submaximal Isometric Strength of the Knee Extensor and Flexor Muscles.The American journal of sports medicine · 2024Observational
- Resistance band training with functional electrical stimulation improves force control capabilities in older adults: a preliminary study.EXCLI journal · 2024Article
- Lower motor unit discharge rates in gastrocnemius lateralis, but not in gastrocnemius medialis or soleus, in runners with Achilles tendinopathy: a pilot study.European journal of applied physiology · 2023Article
- Test-retest reliability and construct validity of trunk extensor muscle force modulation accuracy.PloS one · 2023Article
- Corticospinal and peripheral responses to heat-induced hypo-hydration: potential physiological mechanisms and implications for neuromuscular function.European journal of applied physiology · 2022Review
- Multi-Site Observational Study to Assess Biomarkers for Susceptibility or Resilience to Chronic Pain: The Acute to Chronic Pain Signatures (A2CPS) Study Protocol.Frontiers in medicine · 2022Article
- Submaximal Force Steadiness and Accuracy in Patients With Chronic Ankle Instability.Journal of athletic training · 2021Article
- Article
- Force control during submaximal isometric contractions is associated with walking performance in persons with multiple sclerosis.Journal of neurophysiology · 2020Article
- Best Evidence Rehabilitation for Chronic Pain Part 5: Osteoarthritis.Journal of clinical medicine · 2019Review
- Deficits in Quadriceps Force Control After Anterior Cruciate Ligament Injury: Potential Central Mechanisms.Journal of athletic training · 2019Article
- Quadriceps Weakness in Individuals with Coexisting Medial and Lateral Osteoarthritis.JB & JS open access · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPopulations with knee joint damage, including arthritis, have noted impairments in the regulation of submaximal muscle force. It is difficult to determine the exact cause of such impairments given the joint pathology and associated neuromuscular adaptations. Experimental pain models that have been used to isolate the effects of pain on muscle force regulation have shown impaired force steadiness during acute pain. However, few studies have examined force regulation during dynamic contractions, and these findings have been inconsistent. The goal of the current study was to examine the effect of experimental knee joint pain on submaximal quadriceps force regulation during isometric and dynamic contractions.
methodsThe study involved fifteen healthy participants. Participants were seated in an isokinetic dynamometer. Knee extensor force matching tasks were completed in isometric, eccentric, and concentric muscle contraction conditions. The target force was set to 10 % of maximum for each contraction type. Hypertonic saline was then injected into the infrapatella fat pad to generate acute joint pain. The force matching tasks were repeated during pain and once more 5 min after pain had subsided.
resultsHypertonic saline resulted in knee pain with an average peak pain rating of 5.5 ± 2.1 (0-10 scale) that lasted for 18 ± 4 mins. Force steadiness significantly reduced during pain across all three muscle contraction conditions. There was a trend to increased force matching error during pain but this was not significant.
conclusionExperimental knee pain leads to impaired quadriceps force steadiness during isometric, eccentric, and concentric contractions, providing further evidence that joint pain directly affects motor performance. Given the established relationship between submaximal muscle force steadiness and function, such an effect may be detrimental to the performance of tasks in daily life. In order to restore motor performance in people with painful arthritic conditions of the knee, it may be important to first manage their pain more effectively.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.