ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Spontaneous Activity Patterns in Primary Visual Cortex Predispose to Visual Hallucinations.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed.
- Shared and Diverging Neural Dynamics Underlying False and Veridical Perception.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Expectation Cues and False Percepts Generate Stimulus-Specific Activity in Distinct Layers of the Early Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Decoding cognition from spontaneous neural activity.Nature reviews. Neuroscience · 2022Review
- Oculomotor freezing indicates conscious detection free of decision bias.Journal of neurophysiology · 2022Article
- No common factor for illusory percepts, but a link between pareidolia and delusion tendency: A test of predictive coding theory.Frontiers in psychology · 2022Article
- Hallucination, imagery, dreaming: reassembling stimulus-independent perceptions based on Edmund Parish's classic misperception framework.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Clear Theories Are Needed to Interpret Differences: Perspectives on the Bilingual Advantage Debate.Neurobiology of language (Cambridge, Mass.) · 2021Review
- Prior Expectations of Motion Direction Modulate Early Sensory Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Antipsychotic agents deteriorate brain and retinal function in schizophrenia patients with combined auditory and visual hallucinations: A pilot study and secondary follow-up study.Brain and behavior · 2020Article
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- Defending subjective inflation: an inference to the best explanation.Neuroscience of consciousness · 2020Article
- A dual role of prestimulus spontaneous neural activity in visual object recognition.Nature communications · 2019Article
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- Cerebello-thalamo-cortical hyperconnectivity as a state-independent functional neural signature for psychosis prediction and characterization.Nature communications · 2018Article
- Prior expectations induce prestimulus sensory templates.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Time-compressed preplay of anticipated events in human primary visual cortex.Nature communications · 2017Article
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- Predictions Shape Confidence in Right Inferior Frontal Gyrus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Serial Dependence in Perceptual Decisions Is Reflected in Activity Patterns in Primary Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Article
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4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
According to theoretical frameworks casting perception as inference, vision results from the integration of bottom-up visual input with top-down expectations. Under conditions of strongly degraded sensory input, this may occasionally result in false perceptions in the absence of a sensory signal, also termed "hallucinations." Here, we investigated whether spontaneous prestimulus activity patterns in sensory circuits, which may embody a participant's prior expectations, predispose the observer toward false perceptions. Specifically, we used fMRI to investigate whether the representational content of prestimulus activity in early visual cortex is linked to subsequent perception during a challenging detection task. Human participants were asked to detect oriented gratings of a particular orientation that were embedded in noise. We found two characteristics of prestimulus activity that predisposed participants to hallucinations: overall lower prestimulus activity and a bias in the prestimulus activity patterns toward the to-be-detected (expected) grating. These results suggest that perceptual hallucinations may be due to an imprecise and biased state of sensory circuits preceding sensory evidence collection. SIGNIFICANCE STATEMENT: When sensory stimulation is strongly degraded, we occasionally misperceive a stimulus when only noise is present: a perceptual hallucination. Using fMRI in healthy participants, we investigated whether the state of early visual cortex preceding stimulus onset predisposes an observer to hallucinations. We found two characteristics of prestimulus activity that predisposed participants to hallucinations: overall lower prestimulus activity and a bias in the prestimulus activity patterns toward the expected grating. These results suggest that perceptual hallucinations are due to an imprecise and biased state of sensory circuits preceding sensation.
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