ArticleCellular and molecular life sciences : CMLS2016
MALT1 is not alone after all: identification of novel paracaspases.
Article in Cellular and molecular life sciences : CMLS, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Therapeutic targeting of MALT1 in oncology: Mechanism, inhibitor development, and clinical prospects.Journal of cell communication and signaling · 2026Review
- In silico insight of cell-death-related proteins in photosynthetic cyanobacteria.Archives of microbiology · 2022Review
- MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity.Nature communications · 2020Article
- Review
- Pharmacological Inhibition of MALT1 Protease Leads to a Progressive IPEX-Like Pathology.Frontiers in immunology · 2020Article
- MALT1 Proteolytic Activity Suppresses Autoimmunity in a T Cell Intrinsic Manner.Frontiers in immunology · 2019Article
- Metacaspases: Potential Drug Target Against Protozoan Parasites.Frontiers in pharmacology · 2019Review
- Mepazine Inhibits RANK-Induced Osteoclastogenesis Independent of Its MALT1 Inhibitory Function.Molecules (Basel, Switzerland) · 2018Article
- GC Content of Early Metazoan Genes and Its Impact on Gene Expression Levels in Mammalian Cell Lines.Genome biology and evolution · 2018Article
- AFrontiers in immunology · 2018Article
- Structural and functional diversity of caspase homologues in non-metazoan organisms.Protoplasma · 2018Review
- Ways and waves of MALT1 paracaspase activation.Cellular & molecular immunology · 2018Article
- Ancient Origin of the CARD-Coiled Coil/Bcl10/MALT1-Like Paracaspase Signaling Complex Indicates Unknown Critical Functions.Frontiers in immunology · 2018Article
- Holding All the CARDs: How MALT1 Controls CARMA/CARD-Dependent Signaling.Frontiers in immunology · 2018Review
- Metacaspases versus caspases in development and cell fate regulation.Cell death and differentiation · 2017Review
- Regulated Forms of Cell Death in Fungi.Frontiers in microbiology · 2017Review
- Two Antagonistic MALT1 Auto-Cleavage Mechanisms Reveal a Role for TRAF6 to Unleash MALT1 Activation.PloS one · 2017Article
- The paracaspase MALT1 mediates CARD14-induced signaling in keratinocytes.EMBO reports · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Paracaspases and metacaspases are two families of caspase-like proteins identified in 2000. Up until now paracaspases were considered a single gene family with one known non-metazoan paracaspase in the slime mold Dictyostelium and a single animal paracaspase called MALT1. Human MALT1 is a critical signaling component in many innate and adaptive immunity pathways that drive inflammation, and when it is overly active, it can also cause certain forms of cancer. Here, we report the identification and functional analysis of two new vertebrate paracaspases, PCASP2 and PCASP3. Functional characterization indicates that both scaffold and protease functions are conserved across the three vertebrate paralogs. This redundancy might explain the loss of two of the paralogs in mammals and one in Xenopus. Several of the vertebrate paracaspases currently have incorrect or ambiguous annotations. We propose to annotate them accordingly as PCASP1, PCASP2, and PCASP3 similar to the caspase gene nomenclature. A comprehensive search in other metazoans and in non-metazoan species identified additional new paracaspases. We also discovered the first animal metacaspase in the sponge Amphimedon. Comparative analysis of the active site suggests that paracaspases constitute one of the several subclasses of metacaspases that have evolved several times independently.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.