Evidence map›Paper›PMID 26377252›Full record

ArticleNeurology2015

Eating behavior in frontotemporal dementia: Peripheral hormones vs hypothalamic pathology.

Rebekah M Ahmed, Sahar Latheef, Lauren Bartley, Muireann Irish, Glenda M Halliday, Matthew C Kiernan, John R Hodges, Olivier Piguet

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Changes in body composition in genetic C9orf72 carriers: The role of the hypothalamus and thalamus.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  2. Investigating Disordered Eating Behaviours Among Individuals Living With Neurodegenerative Disease: A Scoping Review.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026
    Article
  3. Article
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  9. Amyotrophic Lateral Sclerosis: A Diet Review.Foods (Basel, Switzerland) · 2021
    Review
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  18. Plasma proteomic signatures predict dementia and cognitive impairment.Alzheimer's & dementia (New York, N. Y.) · 2020
    Article
  19. Neural networks associated with body composition in frontotemporal dementia.Annals of clinical and translational neurology · 2019
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Rebekah M AhmedFrom Neuroscience Research Australia (R.M.A., S.L., L.B., M.I., G.M.H., M.C.K., J.R.H., O.P.), Sydney; Prince of Wales Clinical School (R.M.A.), School of Medical Sciences (G.M.H., J.R.H., O.P.), School of Psychology (M.I.), and ARC Centre of Excellence in Cognition and Its Disorders (R.M.A., M.I., J.R.H., O.P.), the University of New South Wales, Sydney; and Sydney Medical School (M.C.K.), Brain and Mind Centre, University of Sydney, Australia. r.ahmed@neura.edu.au o.piguet@neura.edu.au.
Sahar LatheefFrom Neuroscience Research Australia (R.M.A., S.L., L.B., M.I., G.M.H., M.C.K., J.R.H., O.P.), Sydney; Prince of Wales Clinical School (R.M.A.), School of Medical Sciences (G.M.H., J.R.H., O.P.), School of Psychology (M.I.), and ARC Centre of Excellence in Cognition and Its Disorders (R.M.A., M.I., J.R.H., O.P.), the University of New South Wales, Sydney; and Sydney Medical School (M.C.K.), Brain and Mind Centre, University of Sydney, Australia.
Lauren BartleyFrom Neuroscience Research Australia (R.M.A., S.L., L.B., M.I., G.M.H., M.C.K., J.R.H., O.P.), Sydney; Prince of Wales Clinical School (R.M.A.), School of Medical Sciences (G.M.H., J.R.H., O.P.), School of Psychology (M.I.), and ARC Centre of Excellence in Cognition and Its Disorders (R.M.A., M.I., J.R.H., O.P.), the University of New South Wales, Sydney; and Sydney Medical School (M.C.K.), Brain and Mind Centre, University of Sydney, Australia.
Muireann IrishFrom Neuroscience Research Australia (R.M.A., S.L., L.B., M.I., G.M.H., M.C.K., J.R.H., O.P.), Sydney; Prince of Wales Clinical School (R.M.A.), School of Medical Sciences (G.M.H., J.R.H., O.P.), School of Psychology (M.I.), and ARC Centre of Excellence in Cognition and Its Disorders (R.M.A., M.I., J.R.H., O.P.), the University of New South Wales, Sydney; and Sydney Medical School (M.C.K.), Brain and Mind Centre, University of Sydney, Australia.
Glenda M HallidayFrom Neuroscience Research Australia (R.M.A., S.L., L.B., M.I., G.M.H., M.C.K., J.R.H., O.P.), Sydney; Prince of Wales Clinical School (R.M.A.), School of Medical Sciences (G.M.H., J.R.H., O.P.), School of Psychology (M.I.), and ARC Centre of Excellence in Cognition and Its Disorders (R.M.A., M.I., J.R.H., O.P.), the University of New South Wales, Sydney; and Sydney Medical School (M.C.K.), Brain and Mind Centre, University of Sydney, Australia.
Matthew C KiernanFrom Neuroscience Research Australia (R.M.A., S.L., L.B., M.I., G.M.H., M.C.K., J.R.H., O.P.), Sydney; Prince of Wales Clinical School (R.M.A.), School of Medical Sciences (G.M.H., J.R.H., O.P.), School of Psychology (M.I.), and ARC Centre of Excellence in Cognition and Its Disorders (R.M.A., M.I., J.R.H., O.P.), the University of New South Wales, Sydney; and Sydney Medical School (M.C.K.), Brain and Mind Centre, University of Sydney, Australia.
John R HodgesFrom Neuroscience Research Australia (R.M.A., S.L., L.B., M.I., G.M.H., M.C.K., J.R.H., O.P.), Sydney; Prince of Wales Clinical School (R.M.A.), School of Medical Sciences (G.M.H., J.R.H., O.P.), School of Psychology (M.I.), and ARC Centre of Excellence in Cognition and Its Disorders (R.M.A., M.I., J.R.H., O.P.), the University of New South Wales, Sydney; and Sydney Medical School (M.C.K.), Brain and Mind Centre, University of Sydney, Australia.
Olivier PiguetFrom Neuroscience Research Australia (R.M.A., S.L., L.B., M.I., G.M.H., M.C.K., J.R.H., O.P.), Sydney; Prince of Wales Clinical School (R.M.A.), School of Medical Sciences (G.M.H., J.R.H., O.P.), School of Psychology (M.I.), and ARC Centre of Excellence in Cognition and Its Disorders (R.M.A., M.I., J.R.H., O.P.), the University of New South Wales, Sydney; and Sydney Medical School (M.C.K.), Brain and Mind Centre, University of Sydney, Australia. r.ahmed@neura.edu.au o.piguet@neura.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo contrast the relationships of hormonal eating peptides and hypothalamic volumes to eating behavior and metabolic changes (body mass index [BMI]) in behavioral variant frontotemporal dementia (bvFTD) and semantic variant primary progressive aphasia (svPPA).

methodsSeventy-five patients with dementia (19 bvFTD, 26 svPPA, and 30 Alzheimer disease dementia) and 23 controls underwent fasting blood analyses of leptin, ghrelin, cholecystokinin, peptide tyrosine tyrosine (PYY), and agouti-related peptide (AgRP) levels. On brain MRI anterior, posterior, and total hypothalamic volumes were measured. Relationships between endocrine measures, hypothalamic volumes, eating behaviors, and BMI were investigated.

resultsLevels of AgRP were higher in patients with bvFTD (69 ± 89 pg/mL) and svPPA (62 ± 81 pg/mL) compared with controls (23 ± 19 pg/mL, p < 0.01). No differences were found for leptin, oxytocin, cholecystokinin, ghrelin, and PYY levels. Patients with bvFTD and svPPA had higher scores on questionnaires measuring eating behaviors. Atrophy of the posterior and total hypothalamus was observed in the bvFTD group only. Linear regression modeling revealed that leptin and AgRP levels predicted BMI.

conclusionEating abnormalities are multifactorial in FTD. In bvFTD, they are in part related to hypothalamic degeneration, with potential disintegration of the network connections between the hypothalamus and orbitofrontal cortex/reward pathways. In svPPA, although hypothalamic volumes are preserved, this group experiences elevated AgRP levels similar to bvFTD, which predicts BMI in both groups. This finding highlights the potential key role of AgRP in eating and metabolic changes and provides a potential target for treatment to modify disease progression.

Indexed as

Feeding BehaviorAdultAgedAged, 80 and overAlzheimer DiseaseAphasia, Primary ProgressiveFastingFemaleFrontotemporal DementiaHormonesHumansHypothalamusMagnetic Resonance ImagingMaleMiddle AgedPick Disease of the BrainHormones

Identifiers

PMID26377252
PMCPMC4617167

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