ArticleJournal of medical case reports2015
Spontaneous regression of non-small cell lung cancer after biopsy of a mediastinal lymph node metastasis: a case report.
Article in Journal of medical case reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Non-Functional Paraganglioma of the Urinary Bladder: A Rare Cause of Bladder Tumor.IJU case reports · 2026Article
- Spontaneous regression of pulmonary pleomorphic carcinoma after thoracoscopic surgery for hemothorax: A case report.Respiratory medicine case reports · 2026Article
- A Case of Spontaneous Regression of Primary Tumor after Adrenalectomy for Primary Lung Cancer with Synchronous Adrenal Metastasis.Surgical case reports · 2025Article
- Complete and partial spontaneous regression of metastases of lung cancer in a patient: Serial CT andRadiology case reports · 2024Article
- Case report: Spontaneous remission in lung carcinoma with a late relapse after adjuvant immunotherapy: Exceptional tumor micro-environment.Frontiers in immunology · 2023Article
- Temporary spontaneous regression of male breast cancer: a case report.Surgical case reports · 2020Article
- Spontaneous regression of ALK fusion protein-positive non-small cell lung carcinoma: a case report and review of the literature.BMC pulmonary medicine · 2020Review
- Pulmonary artery coil embolisation prevented tumour progression in a patient with advanced squamous cell lung carcinoma.Upsala journal of medical sciences · 2020Article
- Spontaneous remission of advanced progressive poorly differentiated non-small cell lung cancer: a case report and review of literature.BMC pulmonary medicine · 2019Review
- Abscopal effect of high-dose-rate brachytherapy on pelvic bone metastases from renal cell carcinoma: a case report.Journal of contemporary brachytherapy · 2019Article
- Spontaneous Partial Regression of a Carcinoid Tumor: Radiology May Not Capture the Real Picture.Turkish thoracic journal · 2019Article
- Lymph Node Metastasis after Spontaneous Regression of Non-Small Cell Lung Cancer.The Korean journal of thoracic and cardiovascular surgery · 2019Article
- Lobectomy for subsegmental lymph node metastasis of unknown origin.Nagoya journal of medical science · 2019Article
- Spontaneous regression of lung squamous cell carcinoma with synchronous mediastinal progression: A case report.Thoracic cancer · 2018Article
- Spontaneous regression of a primary squamous cell lung cancer following biopsy: a case report.Journal of medical case reports · 2018Article
- Spontaneous Regression of Metastatic Papillary Thyroid Cancer in a Lymph Node.Case reports in endocrinology · 2018Article
- Spontaneous Regression of Epithelioid Angiosarcoma in a Young Woman.Internal medicine (Tokyo, Japan) · 2017Article
- Spontaneous regression of a pulmonary adenocarcinoma after core needle biopsy.Autopsy & case reportsArticle
- "St. Peregrine tumor" with synchronous primary renal cell carcinoma.Lung India : official organ of Indian Chest SocietyArticle
- Progression to Lymph Node Metastasis After Spontaneous Regression of Pulmonary Adenocarcinoma Following Biopsy.In vivo (Athens, Greece)Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSpontaneous regression of cancer is defined as a complete or partial, temporary or permanent disappearance of tumor in the absence of specific therapy. With only a few cases reported, spontaneous regression is extremely rare in primary lung cancer. Regarding spontaneous regression in lung cancer, recent investigations revealed the role of immunological mechanisms, thus indicating potential treatment options by specific immunotherapy in the future. CASE PRESENTATION: A 76-year-old Caucasian man with progressive dyspnea presented to our hospital. A computed tomography scan revealed a tumor mass in the upper lobe of his right lung and enlarged mediastinal lymph nodes. A biopsy of a paratracheal lymph node by mediastinoscopy disclosed metastatic lung cancer. By immunohistochemical findings the tumor was classified as large cell carcinoma. Diagnosed with clinical stage IIIA non-small cell lung cancer, a neoadjuvant therapy concept was indicated. However, before starting chemoradiation, a computed tomography scan showed a regression of both the tumor mass in the upper lobe of his right lung and the mediastinal lymphadenopathy. As a repeated computed tomography scan showed further regression, we agreed with our patient to perform routine follow-up instead of starting therapy. To date, no relapse has been reported.
conclusionsGiven the circumstances that regression started after the biopsy and involved both the tumor in the upper lobe of his right lung and the mediastinal lymph node metastases, an immune response is a reasonable explanation for the observed spontaneous regression in this case.
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