ArticleMolecular neurobiology2016
Cnga2 Knockout Mice Display Alzheimer's-Like Behavior Abnormities and Pathological Changes.
Article in Molecular neurobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 13 citations in OpenAlex.
- A Mouse Model of Sporadic Alzheimer's Disease with Elements of Major Depression.Molecular neurobiology · 2025Article
- Olfactory impairment in psychiatric disorders: Does nasal inflammation impact disease psychophysiology?Translational psychiatry · 2022Review
- Effects of intranasal instillation of nanoparticulate matter in the olfactory bulb.Scientific reports · 2021Article
- Synaptic Dysfunction in Alzheimer's Disease: Aβ, Tau, and Epigenetic Alterations.Molecular neurobiology · 2018Review
- GSK-3β deletion in dentate gyrus excitatory neuron impairs synaptic plasticity and memory.Scientific reports · 2017Article
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Authors and funding
8 authors at 1 institution in 1 country.
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Abstract
Olfactory dysfunction is recognized as a potential risk factor for Alzheimer's disease (AD). We have reported previously that olfactory deprivation by olfactory bulbectomy (OBX) induced Alzheimer's-like pathological changes and behavioral abnormalities. However, the acute OBX model undergoes surgical-induced brain parenchyma loss and unexpected massive hemorrhage so that it cannot fully mimic the progressive olfactory loss and neurodegeneration in AD. Here, we employed the mice loss of cyclic nucleotide-gated channel alpha 2 (Cnga2) which is critical for olfactory sensory transduction, to investigate the role of olfactory dysfunction in AD pathological process. We found that impaired learning and memory abilities, loss of dendrite spines, as well as decrement of synaptic proteins were displayed in Cnga2 knockout mice. Moreover, Aβ overproduction, tau hyperphosphorylation, and somatodendritic translocation were also found in Cnga2 knockout mice. Our findings suggest that progressive olfactory loss leads to Alzheimer's-like behavior abnormities and pathological changes.
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