Evidence map›Paper›PMID 26377047›Full record

ReviewNanomedicine (London, England)2015

Serum protein adsorption and excretion pathways of metal nanoparticles.

Rodrigo D Vinluan, Jie Zheng

Abstract readReview
In one paragraph

Review in Nanomedicine (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Review
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  5. Review
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  8. Article
  9. High-resolution TNature biomedical engineering · 2021
    Article
  10. Probing the biological obstacles of nanomedicine with gold nanoparticles.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2019
    Review
  11. Renal Clearable Luminescent Gold Nanoparticles: From the Bench to the Clinic.Angewandte Chemie (International ed. in English) · 2019
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Rodrigo D VinluanDepartment of Chemistry, The University of Texas at Dallas, Richardson, TX 75080, USA.
Jie ZhengDepartment of Chemistry, The University of Texas at Dallas, Richardson, TX 75080, USA.

Funding

Surface chemistry for high-contrast fluorescence kidney imagingR01DK103363 · NIDDK · UNIVERSITY OF TEXAS DALLAS · PI ZHENG, JIE · 2014 to 2018
$1.3M
Develop a Dual Functional Nanoprobe for Integration of Fluorescence microscopy wiR21EB011762 · NIBIB · UNIVERSITY OF TEXAS DALLAS · PI ZHENG, JIE · 2011 to 2012
$402k
NIBIB NIH HHS R21 EB011762NIBIB NIH HHS R21EB011762NIDDK NIH HHS R01 DK103363NIDDK NIH HHS R01DK103363
6 · The paper itself

Abstract

While the synthesis of metal nanoparticles (NPs) with fascinating optical and electronic properties have progressed dramatically and their potential biomedical applications were also well demonstrated in the past decade, translation of metal NPs into the clinical practice still remains a challenge due to their severe accumulation in the body. Herein, we give a brief review on size-dependent material properties of metal NPs and their potential biomedical applications, followed by a summary of how structural parameters such as size, shape and charge influence their interactions with serum protein adsorption, cellular uptake and excretion pathways. Finally, the future challenges in minimizing serum protein adsorption and expediting clinical translation of metal NPs were also discussed.

Indexed as

AdsorptionAnimalsBlood ProteinsCell MembraneHumansKineticsLiverMetal NanoparticlesNanomedicineNeoplasmsParticle SizeSurface Plasmon ResonanceSurface PropertiesBlood Proteinsbiodistributionclearanceexcretionmetal nanoparticlesnanoparticleprotein adsorptionprotein corona

Identifiers

PMID26377047
PMCPMC4714949

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.