Evidence map›Paper›PMID 26376992›Full record

ArticleWorld journal of urology2016

Impact of preoperative hemoglobin and CRP levels on cancer-specific survival in patients undergoing radical cystectomy for transitional cell carcinoma of the bladder: results of a single-center study.

T Grimm, A Buchner, B Schneevoigt, A Kretschmer, M Apfelbeck, M Grabbert, J F Jokisch, C G Stief, A Karl

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Article in World journal of urology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. CRP/prealbumin, a novel inflammatory index for predicting recurrence after radical resection in gastric cancer patients: post hoc analysis of a randomized phase III trial.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2019
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  18. Impact of serum sodium concentration on survival outcomes in patients with invasive bladder cancer without metastasis treated by cystectomy.International journal of urology : official journal of the Japanese Urological Association · 2019
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  19. [Limits of surgery in uro-oncology].Der Urologe. Ausg. A · 2018
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

T GrimmDepartment of Urology, Ludwig-Maximilians University Munich, Munich, Germany.
A BuchnerDepartment of Urology, Ludwig-Maximilians University Munich, Munich, Germany.
B SchneevoigtDepartment of Urology, Ludwig-Maximilians University Munich, Munich, Germany.
A KretschmerDepartment of Urology, Ludwig-Maximilians University Munich, Munich, Germany.
M ApfelbeckDepartment of Urology, Ludwig-Maximilians University Munich, Munich, Germany.
M GrabbertDepartment of Urology, Ludwig-Maximilians University Munich, Munich, Germany. markus.grabbert@med.uni-muenchen.de.
J F JokischDepartment of Urology, Ludwig-Maximilians University Munich, Munich, Germany.
C G StiefDepartment of Urology, Ludwig-Maximilians University Munich, Munich, Germany.
A KarlDepartment of Urology, Ludwig-Maximilians University Munich, Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeDifferent blood parameters have shown to be associated with patient's oncological outcome. There is only limited knowledge about the prognostic relevance of routine blood parameters in patients undergoing radical cystectomy for transitional cell carcinoma (TCC). Therefore, we retrospectively analyzed the influence of preoperative C-reactive protein (CRP) and hemoglobin (Hb) levels on overall survival (OS) and cancer-specific survival (CSS). MATERIALS AND

methodsPreoperative CRP and Hb levels were available in 664 patients who underwent RC due to TCC from 2004 to 2013 at our institution. More men than women (77 vs. 23 %) underwent surgery with a median age of 70 years (35-97). Median follow-up time was 24 months (max. 108). Outcome was analyzed using Kaplan-Meier method, log-rank test, and Cox regression models.

resultsMedian CRP level was 0.5 mg/dl (0.1-28.3), and median Hb level was 13.4 g/dl (6.7-17.9). Patients with CRP value above the median died significantly earlier due to their disease than those with CRP below the median (median CSS 19 vs. 70 months; p < 0.001). Patients with preoperative Hb level below the median had significantly worse outcome than those with Hb level above the median (median CSS 25 vs. 78 months; p < 0.001). In multivariate analysis, CRP and Hb levels were independent prognostic parameters regarding CSS/OS (CRP p = 0.016/p = 0.004; Hb p = 0.006/p = 0.004, respectively).

conclusionsIn our single-center study, preoperative CRP and Hb levels were found to be independent prognostic factors, indicating impaired outcome in patients undergoing RC for TCC. These findings could be used for individual risk stratification and optimization of therapeutic strategies.

Indexed as

CystectomyAdultAgedAged, 80 and overCarcinoma, Transitional CellC-Reactive ProteinFemaleHemoglobinsHumansMaleMiddle AgedPreoperative PeriodPrognosisRetrospective StudiesSurvival RateUrinary Bladder NeoplasmsC-Reactive ProteinHemoglobinsC-reactive proteinHemoglobinMuscle-invasive transitional cell carcinoma of the bladderPrognostic factorsRadical cystectomy

Identifiers

PMID26376992

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.