ArticleHypertension research : official journal of the Japanese Society of Hypertension2016
Early urinary biomarkers for renal tubular damage in spontaneously hypertensive rats on a high salt intake.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Saliva urea nitrogen for detection of kidney disease in adults: A meta-analysis of diagnostic test accuracy.PloS one · 2025Pooled it
- High dietary salt intake increases urinary NGAL excretion and creatinine clearance in healthy young adults.American journal of physiology. Renal physiology · 2022Trial
- Effect of 3% saline and furosemide on biomarkers of kidney injury and renal tubular function and GFR in healthy subjects - a randomized controlled trial.BMC nephrology · 2019Trial
- Renal Tubule Cell-SpecificHypertension (Dallas, Tex. : 1979) · 2026Article
- Article
- Dietary sodium and health: How much is too much for those with orthostatic disorders?Autonomic neuroscience : basic & clinical · 2022Review
- Serum Untargeted Metabolism Reveals the Mechanism ofNutrients · 2021Article
- High salt diet-induced proximal tubular phenotypic changes and sodium-glucose cotransporter-2 expression are coordinated by cold shock Y-box binding protein-1.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Association of urinary vanin-1 with kidney function decline in hypertensive patients.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Urine tungsten and chronic kidney disease in rural Colorado.Environmental research · 2021Article
- Urinary vanin-1 associated with chronic kidney disease in hypertensive patients: A pilot study.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- Urinary vanin-1 and chronic kidney disease in hypertensive patients.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- Transcriptome Sequencing to Detect the Potential Role of Long Noncoding RNAs in Salt-Sensitive Hypertensive Rats.BioMed research international · 2019Article
- Evaluation of Pathological Association between Stroke-Related QTL and Salt-Induced Renal Injury in Stroke-Prone Spontaneously Hypertensive Rat.BioMed research international · 2019Article
- High-Salt Intake Ameliorates Hyperglycemia and Insulin Resistance in WBN/Kob-Journal of diabetes research · 2018Article
- A high-salt diet enhances leukocyte adhesion in association with kidney injury in young Dahl salt-sensitive rats.Hypertension research : official journal of the Japanese Society of Hypertension · 2017Article
- Biomarkers for Chronic Kidney Disease Associated with High Salt Intake.International journal of molecular sciences · 2017Review
- Novel risk stratification and treatment.Hypertension research : official journal of the Japanese Society of Hypertension · 2016Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A high salt intake exacerbates hypertension and accelerates renal tubular damage in hypertensive patients. However, data concerning early biomarkers for renal tubular change induced by a high salt intake are limited. The objective of this study was to clarify the time course of new biomarkers for renal tubular damage during high salt intake in spontaneously hypertensive rats (SHR). Male SHR received a regular or high-salt diet from 9 to 17 weeks of age. At 10 weeks of age, a high salt intake caused renal tubular damage, which was further exacerbated at 17 weeks of age. Although albuminuria was detected in salt-loaded SHR at 14 weeks of age, urinary excretion of vanin-1 and neutrophil gelatinase-associated lipocalin (NGAL) was elevated in these animals from 10-17 weeks of age. However, kidney injury molecule-1 (Kim-1) was elevated at 15 weeks of age in salt-loaded SHR. These results suggest that urinary vanin-1 and NGAL are potentially early biomarkers for renal tubular damage in SHR under a high salt intake.
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