ArticleBMC gastroenterology2015
Altered intestinal functions and increased local inflammation in insulin-resistant obese subjects: a gene-expression profile analysis.
Article in BMC gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Role of gut microbiota in lead-induced neural damage in diabetic mice.World journal of diabetes · 2026Article
- The MTRNR2L gene family and age-related macular degeneration.Frontiers in immunology · 2026Review
- Metabolic and functional remodeling of colonic macrophages in response to high-fat diet-induced obesity.iScience · 2023Article
- Transcriptional analysis identifies potential novel biomarkers associated with successful ex-vivo perfusion of human donor lungs.Clinical transplantation · 2022Article
- Key Disease Mechanisms Linked to Amyotrophic Lateral Sclerosis in Spinal Cord Motor Neurons.Frontiers in molecular neuroscience · 2022Article
- Multi-organ Coordination of Lipoprotein Secretion by Hormones, Nutrients and Neural Networks.Endocrine reviews · 2021Review
- RNA-Seq transcriptome analysis of ileum in Taiping chicken supplemented with the dietary probiotic.Tropical animal health and production · 2021Article
- Postprandial NMR-Based Metabolic Exchanges Reflect Impaired Phenotypic Flexibility across Splanchnic Organs in the Obese Yucatan Mini-Pig.Nutrients · 2020Article
- A lower duodenal immune response is associated with an increase of insulin resistance in patients with morbid obesity.International journal of obesity (2005) · 2020Article
- Plasma biomarkers of small intestine adaptations in obesity-related metabolic alterations.Diabetology & metabolic syndrome · 2020Article
- Genetic variants in humanin nuclear isoform gene regions show no association with coronary artery disease.BMC research notes · 2019Article
- Comparative analysis of gene expression profiles in children with type 1 diabetes mellitus.Molecular medicine reports · 2019Article
- Enhanced gastrointestinal passive paracellular permeability contributes to the obesity-associated hyperoxaluria.American journal of physiology. Gastrointestinal and liver physiology · 2019Article
- Tissue Immune Cells Fuel Obesity-Associated Inflammation in Adipose Tissue and Beyond.Frontiers in immunology · 2019Review
- Pro-inflammatory gene expression profile in obese adults with high plasma GIP levels.International journal of obesity (2005) · 2018Article
- Role of innate lymphoid cells in obesity and metabolic disease (Review).Molecular medicine reports · 2018Review
- Microbiota regulate intestinal epithelial gene expression by suppressing the transcription factor Hepatocyte nuclear factor 4 alpha.Genome research · 2017Article
- Effect of Endoscopic Gastroplication on the Genome-Wide Transcriptome in the Upper Gastrointestinal Tract.Obesity surgery · 2017Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundMetabolic alterations relevant to postprandial dyslipidemia were previously identified in the intestine of obese insulin-resistant subjects. The aim of the study was to identify the genes deregulated by systemic insulin resistance in the intestine of severely obese subjects.
methodsTranscripts from duodenal samples of insulin-sensitive (HOMA-IR < 3, n = 9) and insulin-resistant (HOMA-IR > 7, n = 9) obese subjects were assayed by microarray (Illumina HumanHT-12).
resultsA total of 195 annotated genes were identified as differentially expressed between these two groups (Fold change > 1.2). Of these genes, 36 were found to be directly involved in known intestinal functions, including digestion, extracellular matrix, endocrine system, immunity and cholesterol metabolism. Interestingly, all differentially expressed genes (n = 8) implicated in inflammation and oxidative stress were found to be upregulated in the intestine of insulin-resistant compared to insulin-sensitive subjects. Metabolic pathway analysis revealed that several signaling pathways involved in immunity and inflammation were significantly enriched in differently expressed genes and were predicted to be activated in the intestine of insulin-resistant subjects. Using stringent criteria (Fold change > 1.5; FDR < 0.05), three genes were found to be significantly and differently expressed in the intestine of insulin-resistant compared to insulin-sensitive subjects: the transcripts of the insulinotropic glucose-dependant peptide (GIP) and of the β-microseminoprotein (MSMB) were significantly reduced, but that of the humanin like-1 (MTRNR2L1) was significantly increased.
conclusionThese results underline that systemic insulin resistance is associated with remodeling of key intestinal functions. Moreover, these data indicate that small intestine metabolic dysfunction is accompanied with a local amplification of low-grade inflammatory process implicating several pathways. Genes identified in this study are potentially triggered throughout the development of intestinal metabolic abnormalities, which could contribute to dyslipidemia, a component of metabolic syndrome and diabetes.
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