Evidence map›Paper›PMID 26376886›Full record

ArticleEuropean radiology2016

Early prediction of response to neoadjuvant chemotherapy in breast cancer patients: comparison of single-voxel (1)H-magnetic resonance spectroscopy and (18)F-fluorodeoxyglucose positron emission tomography.

Nariya Cho, Seock-Ah Im, Keon Wook Kang, In-Ae Park, In Chan Song, Kyung-Hun Lee, Tae-Yong Kim, Hyunjong Lee, In Kook Chun, Hai-Jeon Yoon and 1 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in European radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Comparison of MRI vs. [Journal of clinical medicine · 2023
    Review
  4. MR spectroscopy in breast cancer metabolomics.Analytical science advances · 2021
    Review
  5. Article
  6. Article
  7. Potential Clinical Applications ofNuclear medicine and molecular imaging · 2017
    Review
  8. Article
  9. Breast PET/MR Imaging.Radiologic clinics of North America · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Nariya ChoDepartment of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Republic of Korea.
Seock-Ah ImDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Keon Wook KangDepartment of Nuclear Medicine, Seoul National College of Medicine, Seoul, Republic of Korea.
In-Ae ParkDepartment of Pathology, Seoul National University Hospital, Seoul, Republic of Korea.
In Chan SongDepartment of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Republic of Korea.
Kyung-Hun LeeDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Tae-Yong KimDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Hyunjong LeeDepartment of Nuclear Medicine, Seoul National College of Medicine, Seoul, Republic of Korea.
In Kook ChunDepartment of Nuclear Medicine, Seoul National College of Medicine, Seoul, Republic of Korea.
Hai-Jeon YoonDepartment of Nuclear Medicine, Seoul National College of Medicine, Seoul, Republic of Korea.
Woo Kyung MoonDepartment of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Republic of Korea. moonwk@snu.ac.kr.
Seoul National University Hospital · KRSeoul National University · KRKangwon National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo prospectively compare performances of single-voxel proton magnetic resonance spectroscopy ((1)H-MRS) and (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) in predicting pathologic response to neoadjuvant chemotherapy (NAC) in breast cancer patients.

methodsThirty-five breast cancer patients who received NAC and subsequent surgery were prospectively enrolled. MRS and FDG-PET were performed before and after the 1st NAC cycle. Percentage changes of total choline-containing compounds (tCho) via MRS, and maximum and peak standardized uptake values (SUVmax, SUVpeak) and total lesion glycolysis (TLG) via FDG-PET were measured, and their performances in predicting pathologic complete response (pCR) were compared.

resultsOf the 35 patients, 6 showed pCR and 29 showed non-pCR. Mean % reductions of tCho, SUVmax, SUVpeak, and TLG of the pCR group were larger than those of the non-pCR group (-80.3 ± 13.9 % vs. -32.1 ± 49.4 %, P = 0.025; -54.7 ± 22.1 % vs. -26.3 ± 33.7 %, P = 0.058; -60.7 ± 18.3 % vs. -32.3 ± 23.3 %, P = 0.009; -89.5 ± 8.5 % vs. -52.6 ± 36.2 %, P = 0.020). Diagnostic accuracy (area under ROC curve; Az, 0.911) of the % reduction of tCho was comparable to those of %SUVmax (0.822), SUVpeak (0.862), and TLG (0.879) in distinguishing pCR from non-pCR (all P > 0.05).

conclusionMRS showed comparable performance to FDG-PET in early prediction of pCR in breast cancer patients. KEY POINTS: • MRS can predict response to NAC in breast cancer post-1 (st) cycle. • Changes in tCho and SUV after NAC reflect tumour cellularity changes. • MRS can be an alternative to FDG-PET in predicting response to NAC.

Indexed as

Fluorodeoxyglucose F18RadiopharmaceuticalsAdultAgedBreast NeoplasmsFemaleHumansMagnetic Resonance SpectroscopyMiddle AgedNeoadjuvant TherapyPositron-Emission TomographyPredictive Value of TestsProspective StudiesROC CurveTreatment OutcomeFluorodeoxyglucose F18RadiopharmaceuticalsBreast neoplasmMagnetic resonance imagingMagnetic resonance spectroscopyNeoadjuvant chemotherapyPositron emission tomography

Identifiers

PMID26376886
OpenAlexW1669936478

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.