Trial reportBMC psychiatry2015
Impact of pharmacist intervention on adherence and measurable patient outcomes among depressed patients: a randomised controlled study.
Trial report in BMC psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 10 syntheses or guidelines pooled it, 128 citations in OpenAlex.
- Evaluating the impact of pharmacists in outpatient mental health settings: a systematic review.International journal of clinical pharmacy · 2026Pooled it
- Supported Decision-Making Interventions in Mental Healthcare: A Systematic Review of Evidence on the Outcomes for People With Mental Ill Health.Health expectations : an international journal of public participation in health care and health policy · 2024Pooled it
- Trends, challenges, and priorities for shared decision making in mental health: The first umbrella review.The International journal of social psychiatry · 2023Pooled it
- Shared decision-making interventions for people with mental health conditions.The Cochrane database of systematic reviews · 2022Pooled it
- Effectiveness of interventions to improve medication adherence in adults with depressive disorders: a meta-analysis.BMC psychiatry · 2022Pooled it
- Systematic literature review of pharmacists in general practice in supporting the implementation of shared care agreements in primary care.Systematic reviews · 2022Pooled it
- A Systematic Review of Shared Decision-Making Interventions for Service Users With Serious Mental Illnesses: State of the Science and Future Directions.Psychiatric services (Washington, D.C.) · 2021Pooled it
- Pharmacy-based management for depression in adults.The Cochrane database of systematic reviews · 2019Pooled it
- Interventions for increasing the use of shared decision making by healthcare professionals.The Cochrane database of systematic reviews · 2018Pooled it
- Shared Decision-Making: a Systematic Review Focusing on Mood Disorders.Current psychiatry reports · 2018Pooled it
- A randomized controlled trial of an electronic patient decision aid (PDA) for decision-making around antidepressant use in pregnancy.Archives of women's mental health · 2026Trial
- The impact of clinical pharmacist-physician communication on reducing drug-related problems: a mixed study design in a tertiary teaching Hospital in Xinjiang, China.BMC health services research · 2022Trial
- A novel approach to medicines optimisation post-discharge from hospital: pharmacist-led medicines optimisation clinic.International journal of clinical pharmacy · 2020Trial
- Systematic review exploring the quality of life of patients undergoing mental disorders treatment in the kingdom of Saudi Arabia.Annals of general psychiatry · 2026Review
- Impact of pharmaceutical care interventions on antidepressants adherence and clinical outcomes in depressed patients: A systematic review.Exploratory research in clinical and social pharmacy · 2025Review
- The evolving role of pharmacists in depression care: a scoping review.International journal of clinical pharmacy · 2024Article
- Systematic literature review of the impact of psychiatric pharmacists.The mental health clinician · 2024Review
- Eliciting Depression Patients' Preferences for Medication Management: A Protocol for Discrete Choice Experiment.Patient preference and adherence · 2024Article
- Article
- Impact of a training program on hospital pharmacists' patient-centered communication attitudes and behaviors.Exploratory research in clinical and social pharmacy · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdherence to antidepressant treatment is essential for the effective management of patients with major depressive disorder. Adherence to medication is a dynamic decision-making process, and pharmacists play an important role in improving adherence to antidepressant treatment in different settings within the healthcare system. The aim of this study was to assess whether pharmacist interventions based on shared decision making improved adherence and patient-related outcomes.
methodsThis was a randomised controlled study with a 6-month follow-up. Participants were randomly allocated to two groups: 1) intervention group (IG) (usual pharmacy services plus pharmacist interventions based on shared decision making); or 2) control group (CG) (usual pharmacy services). Recruited patients fulfilled the following inclusion criteria: aged 18 to 60 years diagnosed with a major depressive disorder, and no history of psychosis or bipolar disorders. A research assistant blinded to the group allocations collected all data.
resultsTwo hundred and thirty-nine patients met the inclusion criteria and were randomised to the IG (n = 119) or CG (n = 120). Nineteen patients dropped out of the study during the follow-up phase. After 6 months, patients in the IG had significantly more favorable medication adherence, treatment satisfaction, general overuse beliefs, and specific concern beliefs. However, the groups did not differ in severity of depression or health-related quality of life after 6 months.
conclusionsOur findings emphasise the important role of pharmacists in providing direct patient care in regular pharmacy practice to improve adherence to medications and other patient-reported outcomes.
trial registrationISRCTN34879893, Date assigned: 30/12/2014.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.