ArticleDiabetologia2016
Rapid development of cardiac dysfunction in a canine model of insulin resistance and moderate obesity.
Article in Diabetologia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 21 citations in OpenAlex.
- Dapagliflozin prevents abdominal visceral and subcutaneous adipose tissue dysfunction in the insulin-resistant canine model.Obesity (Silver Spring, Md.) · 2023Article
- Elucidating the primary mechanisms of high-intensity interval training for improved cardiac fitness in obesity.Frontiers in physiology · 2023Review
- Associations among serum insulin, calprotectin, and C-reactive protein concentrations in Miniature Schnauzers with idiopathic hyperlipidemia before and after feeding an ultra-low-fat diet.Journal of veterinary internal medicine · 2022Article
- Molecular Mechanisms of Obesity-Linked Cardiac Dysfunction: An Up-Date on Current Knowledge.Cells · 2021Review
- An Overview of the Role of Adipokines in Cardiometabolic Diseases.Molecules (Basel, Switzerland) · 2020Review
- Impact of sleep deprivation and high-fat feeding on insulin sensitivity and beta cell function in dogs.Diabetologia · 2020Article
- Effect of a Weight Loss Program on Biochemical and Immunological Profile, Serum Leptin Levels, and Cardiovascular Parameters in Obese Dogs.Frontiers in veterinary science · 2020Article
- Article
- Comparative occurrence of diabetes in canine, feline, and few wild animals and their association with pancreatic diseases and ketoacidosis with therapeutic approach.Veterinary world · 2018Review
- Insulin Access to Skeletal Muscle is Preserved in Obesity Induced by Polyunsaturated Diet.Obesity (Silver Spring, Md.) · 2018Article
- Using a respiratory navigator significantly reduces variability when quantifying left ventricular torsion with cardiovascular magnetic resonance.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2017Article
- Insulin access to skeletal muscle is impaired during the early stages of diet-induced obesity.Obesity (Silver Spring, Md.) · 2016Article
- Of mice (dogs) and men: getting to the heart of obesity-associated cardiac dysfunction.Diabetologia · 2016Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
aims/hypothesisThe worldwide incidence of obesity and diabetes continues to rise at an alarming rate. A major cause of the morbidity and mortality associated with obesity and diabetes is heart disease, yet the mechanisms that lead to cardiovascular complications remain unclear.
methodsWe performed cardiac MRI to assess left ventricular morphology and function during the development of moderate obesity and insulin resistance in a well-established canine model (n = 26). To assess the influence of dietary fat composition, we randomised animals to a traditional lard diet (rich in saturated and monounsaturated fat; n = 12), a salmon oil diet (rich in polyunsaturated fat; n = 8) or a control diet (n = 6).
resultsHigh-fat feeding with lard increased body weight and fasting insulin and markedly reduced insulin sensitivity. Lard feeding also significantly reduced left ventricular function, evidenced by a worsening of circumferential strain and impairment in left ventricular torsion. High-fat feeding with salmon oil increased body weight; however, salmon oil feeding did not impair insulin sensitivity or cardiac function. CONCLUSIONS/
interpretationThese data emphasise the importance of dietary fat composition on both metabolic and cardiac function, and have important implications for the relationship between diet and health.
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