ArticleTurkish journal of haematology : official journal of Turkish Society of Haematology2016
D-index: A New Scoring System in Febrile Neutropenic Patients for Predicting Invasive Fungal Infections.
Article in Turkish journal of haematology : official journal of Turkish Society of Haematology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Risk Factors and Environmental Preventive Actions for Aspergillosis in Patients with Hematological Malignancies.Clinics and practice · 2024Review
- Article
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- Serial platelet level index improves prediction of pulmonary hemorrhage in patients withFrontiers in medicine · 2022Article
- c-D-index at day 11 can predict febrile neutropenia during chemotherapy in acute myeloid leukemia.PloS one · 2022Article
- Invasive Fungal Disease in Patients with Newly Diagnosed Acute Myeloid Leukemia.Journal of fungi (Basel, Switzerland) · 2021Article
- D-index as a marker of bloodstream infections in patients with allogeneic hematopoietic stem cell transplantation.Transplant infectious disease : an official journal of the Transplantation Society · 2021Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveNeutropenia is a critical risk factor for invasive fungal infections (IFIs). We retrospectively performed this study to assess the performance of the D-index, a new test that combines both the duration and the severity of neutropenia, in predicting IFIs among patients with acute myelogenous leukemia. MATERIALS AND
methodsFifteen patients with IFIs and 28 patients who did not develop IFIs were enrolled in the study. The D-index was defined as the area over the neutrophil curve, whereas the cumulative-D-index (c-D-index) was the area over the neutrophil curve from the start of neutropenia until the first clinical manifestation of IFI.
resultsThe D-index and the c-D-index tended to be significantly higher in patients with IFIs, with medians of 10,150 (range: 4000-22,000) and 5300 (range: 2300-22,200), respectively (p=0.037 and p=0.003, respectively). The receiver operating characteristic analyses showed that there was a cutoff point of 3875 for the D-index in predicting IFI; the sensitivity, specificity, and positive and negative predictive values were 100%, 67.9%, 35.4%, and 100%, respectively. There was also a cutoff point of 4225 for the c-D-index in predicting IFI; the sensitivity, specificity, and positive and negative predictive values for the c-D-index were 93.3%, 71.4%, 36.6%, and 98.4%.
conclusionThe D-index and especially the c-D-index could be useful tools with high negative predictive value to exclude as well as to predict IFIs in the management of neutropenic patients.
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