Evidence map›Paper›PMID 26376485›Full record

ArticlePloS one2015

Characteristics of Human Turbinate-Derived Mesenchymal Stem Cells Are Not Affected by Allergic Condition of Donor.

Se Hwan Hwang, Hye Kyung Cho, Sang Hi Park, WeonSun Lee, Hee Jin Lee, Dong Chang Lee, Sun Hwa Park, Mi Hyun Lim, Sang A Back, Byeong Gon Yun and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Se Hwan HwangDepartment of Otolaryngology-Head and Neck Surgery, The Catholic University of Korea, College of Medicine, Seoul, Korea.
Hye Kyung ChoDepartment of Pediatrics, Graduate School of Medicine, Gachon University, Incheon, Korea.
Sang Hi ParkInstitute of Clinical Medicine Research, College of Medicine, Catholic University of Korea, Seoul, Korea.
WeonSun LeeInstitute of Clinical Medicine Research, College of Medicine, Catholic University of Korea, Seoul, Korea.
Hee Jin LeeInstitute of Clinical Medicine Research, College of Medicine, Catholic University of Korea, Seoul, Korea.
Dong Chang LeeDepartment of Otolaryngology-Head and Neck Surgery, The Catholic University of Korea, College of Medicine, Seoul, Korea.
Sun Hwa ParkDepartment of Otolaryngology-Head and Neck Surgery, The Catholic University of Korea, College of Medicine, Seoul, Korea; Department of biomedical science, The Catholic University of Korea, College of Medicine, Seoul, Korea.
Mi Hyun LimDepartment of Otolaryngology-Head and Neck Surgery, The Catholic University of Korea, College of Medicine, Seoul, Korea; Department of biomedical science, The Catholic University of Korea, College of Medicine, Seoul, Korea.
Sang A BackDepartment of Otolaryngology-Head and Neck Surgery, The Catholic University of Korea, College of Medicine, Seoul, Korea.
Byeong Gon YunDepartment of Otolaryngology-Head and Neck Surgery, The Catholic University of Korea, College of Medicine, Seoul, Korea; Department of biomedical science, The Catholic University of Korea, College of Medicine, Seoul, Korea.
Dong Il SunDepartment of Otolaryngology-Head and Neck Surgery, The Catholic University of Korea, College of Medicine, Seoul, Korea.
Jun Myung KangDepartment of Otolaryngology-Head and Neck Surgery, The Catholic University of Korea, College of Medicine, Seoul, Korea.
Sung Won KimDepartment of Otolaryngology-Head and Neck Surgery, The Catholic University of Korea, College of Medicine, Seoul, Korea.
Catholic University of Korea · KRGachon University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The characteristics of mesenchymal stem cells (MSCs) derived from human turbinates (hTMSCs) have not been investigated in allergic rhinitis. We evaluated the influence of allergic state of the donor on the characteristics, proliferation, and differentiation potential of hTMSCs, compared with hTMSCs derived from non-allergic patients. hTMSCs were isolated from five non-allergic and five allergic patients. The expression of toll-like receptors (TLRs) in hTMSCs was measured by FACS, and cell proliferation was measured using a cell counting kit. Cytokine secretion was analyzed using multiplex immunoassays. The osteogenic, chondrogenic, and adipogenic differentiation potentials of hTMSCs were evaluated by histology and gene expression analysis. In allergic patients, FACS analysis showed that TLR3 and TLR4 were more highly expressed on the surface of hTMSCs than TLR2 and TLR5. The proliferation of hTMSCs was not influenced by the presence of TLR priming. The expression of IL-6, IL-8, IL-12, IP-10, and RANTES was upregulated after the TLR4 priming. The differentiation potential of hTMSCs was not influenced by TLR priming. These characteristics of hTMSCs were similar to those of hTMSCs from non-allergic patients. We conclude that the allergic condition of the donor does not influence TLR expression, proliferation, or immunomodulatory potential of hTMSCs.

Indexed as

AllergensAntigens, SurfaceBlotting, WesternCell DifferentiationCell ProliferationCells, CulturedCytokinesFlow CytometryHumansMesenchymal Stem CellsReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionRhinitis, AllergicRhinitis, AtrophicRNA, MessengerToll-Like ReceptorsAllergensAntigens, SurfaceCytokinesRNA, MessengerToll-Like Receptors

Identifiers

PMID26376485
PMCPMC4574043
OpenAlexW2207416616

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.