Evidence map›Paper›PMID 26376462›Full record

ArticleJournal of biomedical informatics2015

Textual inference for eligibility criteria resolution in clinical trials.

Chaitanya Shivade, Courtney Hebert, Marcelo Lopetegui, Marie-Catherine de Marneffe, Eric Fosler-Lussier, Albert M Lai

Abstract read
In one paragraph

Article in Journal of biomedical informatics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Combining human and machine intelligence for clinical trial eligibility querying.Journal of the American Medical Informatics Association : JAMIA · 2022
    Article
  5. Review
  6. Article
  7. Article
  8. Automatic trial eligibility surveillance based on unstructured clinical data.International journal of medical informatics · 2019
    Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Automatic data source identification for clinical trial eligibility criteria resolution.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2016
    Article
  15. Article
  16. Creation of a new longitudinal corpus of clinical narratives.Journal of biomedical informatics · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chaitanya ShivadeDepartment of Computer Science and Engineering, The Ohio State University, Columbus, OH, USA. Electronic address: shivade@cse.ohio-state.edu.
Courtney HebertDepartment of Biomedical Informatics, The Ohio State University, Columbus, OH, USA.
Marcelo LopeteguiDepartment of Biomedical Informatics, The Ohio State University, Columbus, OH, USA; Clínica Alemana de Santiago, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago, Chile.
Marie-Catherine de MarneffeDepartment of Linguistics, The Ohio State University, Columbus, OH, USA.
Eric Fosler-LussierDepartment of Computer Science and Engineering, The Ohio State University, Columbus, OH, USA.
Albert M LaiDepartment of Biomedical Informatics, The Ohio State University, Columbus, OH, USA.

Funding

An Information Fusion Approach to Longitudinal Health RecordsR01LM011116 · NLM · OHIO STATE UNIVERSITY · PI LAI, ALBERT M · 2012 to 2015
$1.3M
Challenges in Natural Language Processing in Clinical TextR13LM011411 · NLM · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI UZUNER, OZLEM · 2012 to 2016
$98k
NLM NIH HHS R01 LM011116NLM NIH HHS R13 LM011411
6 · The paper itself

Abstract

Clinical trials are essential for determining whether new interventions are effective. In order to determine the eligibility of patients to enroll into these trials, clinical trial coordinators often perform a manual review of clinical notes in the electronic health record of patients. This is a very time-consuming and exhausting task. Efforts in this process can be expedited if these coordinators are directed toward specific parts of the text that are relevant for eligibility determination. In this study, we describe the creation of a dataset that can be used to evaluate automated methods capable of identifying sentences in a note that are relevant for screening a patient's eligibility in clinical trials. Using this dataset, we also present results for four simple methods in natural language processing that can be used to automate this task. We found that this is a challenging task (maximum F-score=26.25), but it is a promising direction for further research.

Indexed as

Natural Language ProcessingPatient SelectionClinical Trials as TopicData MiningElectronic Health RecordsEligibility DeterminationHumansPattern Recognition, AutomatedVocabulary, ControlledClinical trialsElectronic health recordsNatural language processingTextual inference

Identifiers

PMID26376462
PMCPMC4978353

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.