ArticleMagnetic resonance in medicine2016
Influence of water compartmentation and heterogeneous relaxation on quantitative magnetization transfer imaging in rodent brain tumors.
Article in Magnetic resonance in medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Joint estimation of compartment-specific TMagnetic resonance in medicine · 2025Article
- Single-point macromolecular proton fraction mapping using a 0.3 T permanent magnet MRI system: phantom and healthy volunteer study.Radiological physics and technology · 2024Article
- Demyelination in Patients with POST-COVID Depression.Journal of clinical medicine · 2024Article
- Article
- Diffusion time dependency of extracellular diffusion.Magnetic resonance in medicine · 2023Article
- Towards differentiation of brain tumor from radiation necrosis using multi-parametric MRI: Preliminary results at 4.7 T using rodent models.Magnetic resonance imaging · 2022Article
- Improving MR cell size imaging by inclusion of transcytolemmal water exchange.NMR in biomedicine · 2022Article
- Macromolecular Proton Fraction as a Myelin Biomarker: Principles, Validation, and Applications.Frontiers in neuroscience · 2022Review
- MR cell size imaging with temporal diffusion spectroscopy.Magnetic resonance imaging · 2021Review
- Microstructure Modeling of High b-Value Diffusion-Weighted Images in Glioblastoma.Tomography (Ann Arbor, Mich.) · 2020Article
- Iron-Insensitive Quantitative Assessment of Subcortical Gray Matter Demyelination in Multiple Sclerosis Using the Macromolecular Proton Fraction.AJNR. American journal of neuroradiology · 2018Article
- Quantitative Magnetization Transfer in Monitoring Glioblastoma (GBM) Response to Therapy.Scientific reports · 2018Article
- Article
- Evaluation and comparison of diffusion MR methods for measuring apparent transcytolemmal water exchange rate constant.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2017Article
- Quantitative Magnetization Transfer Imaging of the Breast at 3.0 T: Reproducibility in Healthy Volunteers.Tomography (Ann Arbor, Mich.) · 2016Article
- R1 correction in amide proton transfer imaging: indication of the influence of transcytolemmal water exchange on CEST measurements.NMR in biomedicine · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe goal of this study was to investigate the influence of water compartmentation and heterogeneous relaxation properties on quantitative magnetization transfer (qMT) imaging in tissues, and in particular whether a two-pool model is sufficient to describe qMT data in brain tumors.
methodsComputer simulations and in vivo experiments with a series of qMT measurements before and after injection of Gd-DTPA were performed. Both off-resonance pulsed saturation (pulsed) and on-resonance selective inversion recovery (SIR) qMT methods were used, and all data were fit with a two-pool model only.
resultsSimulations indicated that a two-pool fitting of four-pool data yielded accurate measures of pool size ratio (PSR) of macromolecular versus free water protons when there were fast transcytolemmal exchange and slow R1 recovery. The fitted in vivo PSR of both pulsed and SIR qMT methods showed no dependence on R1 variations caused by different concentrations of Gd-DTPA during wash-out, whereas the fitted kex (magnetization transfer exchange rate) changed significantly with R1 .
conclusionA two-pool model provides reproducible estimates of PSR in brain tumors independent of relaxation properties in the presence of relatively fast transcytolemmal exchange, whereas estimates of kex are biased by relaxation variations. In addition, estimates of PSR in brain tumors using the pulsed and SIR qMT methods agree well with one another. Magn Reson Med 76:635-644, 2016. © 2015 Wiley Periodicals, Inc.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.