ArticlePloS one2015
Comprehensive Analysis of the Naturally Processed Peptide Repertoire: Differences between HLA-A and B in the Immunopeptidome.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed.
- Human iPSC-derived neurons stimulated with IFNγ present HLA class I-restricted antigens to cytotoxic CD8Journal of neuroinflammation · 2026Article
- Human neurons stimulated with IFNγ present HLA class I-restricted autoantigens to cytotoxic CD8bioRxiv : the preprint server for biology · 2026Article
- T cell receptor clonotypes predict human leukocyte antigen allele carriage and antigen exposure history.Communications biology · 2026Article
- HLA evolutionary divergence (HED) informs the effect of HLA-B mismatch on outcomes after haploidentical transplantation.Bone marrow transplantation · 2024Article
- Effect of HLA Genotype on Anti-PD-1 Antibody Treatment for Advanced Renal Cell Carcinoma in the SNiP-RCC Study.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Subcellular location of source proteins improves prediction of neoantigens for immunotherapy.The EMBO journal · 2022Article
- Molecular Characterization of MHC Class I Alpha 1 and 2 Domains in Asian Seabass (International journal of molecular sciences · 2022Article
- Differential role of HLA-A and HLA-B, C expression levels as prognostic markers in colon and rectal cancer.Journal for immunotherapy of cancer · 2022Article
- Progress in kidney transplantation: The role for systems immunology.Frontiers in medicine · 2022Review
- HLA variants have different preferences to present proteins with specific molecular functions which are complemented in frequent haplotypes.Frontiers in immunology · 2022Article
- Unique Pathogen Peptidomes Facilitate Pathogen-Specific Selection and Specialization of MHC Alleles.Molecular biology and evolution · 2021Article
- HLA binding of self-peptides is biased towards proteins with specific molecular functions.bioRxiv : the preprint server for biology · 2021Article
- Differential immunomodulatory effect of PARP inhibition in BRCA1 deficient and competent tumor cells.Biochemical pharmacology · 2021Article
- Identification of Promiscuous African Swine Fever Virus T-Cell Determinants Using a Multiple Technical Approach.Vaccines · 2021Article
- Structural Comparison Between MHC Classes I and II; in Evolution, a Class-II-Like Molecule Probably Came First.Frontiers in immunology · 2021Article
- Epstein-Barr Virus+ B Cells in Breast Cancer Immune Response: A Case Report.Frontiers in immunology · 2021Article
- Most Japanese individuals are genetically predisposed to recognize an immunogenic protein fragment shared between COVID-19 and common cold coronaviruses.F1000Research · 2021Article
- Immunoinformatics: Predicting Peptide-MHC Binding.Annual review of biomedical data science · 2020Article
- Identification of Common CD8Journal of virology · 2020Article
- Expected immune recognition of COVID-19 virus by memory from earlier infections with common coronaviruses in a large part of the world population.F1000Research · 2020Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cytotoxic T cell (CTL) response is determined by the peptide repertoire presented by the HLA class I molecules of an individual. We performed an in-depth analysis of the peptide repertoire presented by a broad panel of common HLA class I molecules on four B lymphoblastoid cell-lines (BLCL). Peptide elution and mass spectrometry analysis were utilised to investigate the number and abundance of self-peptides. Altogether, 7897 unique self-peptides, derived of 4344 proteins, were eluted. After viral infection, the number of unique self-peptides eluted significantly decreased compared to uninfected cells, paralleled by a decrease in the number of source proteins. In the overall dataset, the total number of unique self-peptides eluted from HLA-B molecules was larger than from HLA-A molecules, and they were derived from a larger number of source proteins. These results in B cells suggest that HLA-B molecules possibly present a more diverse repertoire compared to their HLA-A counterparts, which may contribute to their immunodominance. This study provides a unique data set giving new insights into the complex system of antigen presentation for a broad panel of HLA molecules, many of which were never studied this extensively before.
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