ArticleEndocrinology2015
The ERα-PI3K Cascade in Proopiomelanocortin Progenitor Neurons Regulates Feeding and Glucose Balance in Female Mice.
Open access · bronzeAbstract read
In one paragraph
Article in Endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 38 citations in OpenAlex.
- Sexual dimorphism in the development and function of the melanocortin system.Reviews in endocrine & metabolic disorders · 2026Review
- Hypothalamic actions of estrogens in the regulation of energy and glucose homeostasis.Reviews in endocrine & metabolic disorders · 2026Review
- The role of MICOS in modulating mitochondrial dynamics and structural changes in vulnerable regions of Alzheimer's Disease.bioRxiv : the preprint server for biology · 2025Article
- Identification of an ionic mechanism for ERα-mediated rapid excitation in neurons.Science advances · 2024Article
- 27-Hydroxycholesterol acts on estrogen receptor α expressed by POMC neurons in the arcuate nucleus to modulate feeding behavior.Science advances · 2024Article
- Estrogen signaling in the dorsal raphe regulates binge-like drinking in mice.Translational psychiatry · 2024Article
- Review
- Estrogen receptor α activation modulates the gut microbiome and type 2 diabetes risk factors.Physiological reports · 2022Article
- Short-term high-fat diet alters the mouse brain magnetic resonance imaging parameters consistently with neuroinflammation on males and metabolic rearrangements on females. A pre-clinical study with an optimized selection of linear mixed-effects models.Frontiers in neuroscience · 2022Article
- Hypothalamic Estrogen Signaling and Adipose Tissue Metabolism in Energy Homeostasis.Frontiers in endocrinology · 2022Review
- Hypothalamic steroid receptor coactivator-2 regulates adaptations to fasting and overnutrition.Cell reports · 2021Article
- Insulin actions on hypothalamic glucose-sensing neurones.Journal of neuroendocrinology · 2021Review
- Hypothalamic Perineuronal Nets Are Regulated by Sex and Dietary Interventions.Frontiers in physiology · 2021Article
- 17β-estradiol promotes acute refeeding in hungry mice via membrane-initiated ERα signaling.Molecular metabolism · 2020Article
- Vitamin D actions in neurons require the PI3K pathway for both enhancing insulin signaling and rapid depolarizing effects.The Journal of steroid biochemistry and molecular biology · 2020Article
- Combined virgin coconut oil and tocotrienol-rich fraction protects against bone loss in osteoporotic rat model.Veterinary world · 2019Article
- Loss of Nuclear and Membrane Estrogen Receptor-α Differentially Impairs Insulin Secretion and Action in Male and Female Mice.Diabetes · 2019Article
- Mechanisms for Sex Differences in Energy Homeostasis.Journal of molecular endocrinology · 2019Review
- Estrogen Improves Insulin Sensitivity and Suppresses Gluconeogenesis via the Transcription Factor Foxo1.Diabetes · 2019Article
- Central regulation of energy metabolism by estrogens.Molecular metabolism · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 8 institutions in 2 countries.
Liangru ZhuChildren's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medicine, and Brown Foundation Institute of Molecular Medicine (Q.T.), University of Texas Health Science Center at Houston, Houston, Texas 77030; Department of Gastroenterology (L.Z.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China; Medical College of Qingdao University (C.Y.), Qingdao 266020, People's Republic of China; Department of Cancer Biology (S.A.K.), Vontz Center for Molecular Studies, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267; Department of Pathology (J.Z.), Harvard Medical School, and Department of Cancer Biology Dana-Farber Cancer Institute, Boston, Massachusetts 02115; and Department of Biomedical Research (D.J.C.), Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048.
Pingwen XuChildren's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medicine, and Brown Foundation Institute of Molecular Medicine (Q.T.), University of Texas Health Science Center at Houston, Houston, Texas 77030; Department of Gastroenterology (L.Z.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China; Medical College of Qingdao University (C.Y.), Qingdao 266020, People's Republic of China; Department of Cancer Biology (S.A.K.), Vontz Center for Molecular Studies, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267; Department of Pathology (J.Z.), Harvard Medical School, and Department of Cancer Biology Dana-Farber Cancer Institute, Boston, Massachusetts 02115; and Department of Biomedical Research (D.J.C.), Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048.
Xuehong CaoChildren's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medicine, and Brown Foundation Institute of Molecular Medicine (Q.T.), University of Texas Health Science Center at Houston, Houston, Texas 77030; Department of Gastroenterology (L.Z.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China; Medical College of Qingdao University (C.Y.), Qingdao 266020, People's Republic of China; Department of Cancer Biology (S.A.K.), Vontz Center for Molecular Studies, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267; Department of Pathology (J.Z.), Harvard Medical School, and Department of Cancer Biology Dana-Farber Cancer Institute, Boston, Massachusetts 02115; and Department of Biomedical Research (D.J.C.), Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048.
Yongjie YangChildren's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medicine, and Brown Foundation Institute of Molecular Medicine (Q.T.), University of Texas Health Science Center at Houston, Houston, Texas 77030; Department of Gastroenterology (L.Z.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China; Medical College of Qingdao University (C.Y.), Qingdao 266020, People's Republic of China; Department of Cancer Biology (S.A.K.), Vontz Center for Molecular Studies, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267; Department of Pathology (J.Z.), Harvard Medical School, and Department of Cancer Biology Dana-Farber Cancer Institute, Boston, Massachusetts 02115; and Department of Biomedical Research (D.J.C.), Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048.
Antentor Othrell HintonChildren's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medicine, and Brown Foundation Institute of Molecular Medicine (Q.T.), University of Texas Health Science Center at Houston, Houston, Texas 77030; Department of Gastroenterology (L.Z.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China; Medical College of Qingdao University (C.Y.), Qingdao 266020, People's Republic of China; Department of Cancer Biology (S.A.K.), Vontz Center for Molecular Studies, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267; Department of Pathology (J.Z.), Harvard Medical School, and Department of Cancer Biology Dana-Farber Cancer Institute, Boston, Massachusetts 02115; and Department of Biomedical Research (D.J.C.), Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048.
Yan XiaChildren's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medicine, and Brown Foundation Institute of Molecular Medicine (Q.T.), University of Texas Health Science Center at Houston, Houston, Texas 77030; Department of Gastroenterology (L.Z.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China; Medical College of Qingdao University (C.Y.), Qingdao 266020, People's Republic of China; Department of Cancer Biology (S.A.K.), Vontz Center for Molecular Studies, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267; Department of Pathology (J.Z.), Harvard Medical School, and Department of Cancer Biology Dana-Farber Cancer Institute, Boston, Massachusetts 02115; and Department of Biomedical Research (D.J.C.), Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048.
Kenji SaitoChildren's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medicine, and Brown Foundation Institute of Molecular Medicine (Q.T.), University of Texas Health Science Center at Houston, Houston, Texas 77030; Department of Gastroenterology (L.Z.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China; Medical College of Qingdao University (C.Y.), Qingdao 266020, People's Republic of China; Department of Cancer Biology (S.A.K.), Vontz Center for Molecular Studies, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267; Department of Pathology (J.Z.), Harvard Medical School, and Department of Cancer Biology Dana-Farber Cancer Institute, Boston, Massachusetts 02115; and Department of Biomedical Research (D.J.C.), Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048.
Xiaofeng YanChildren's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medicine, and Brown Foundation Institute of Molecular Medicine (Q.T.), University of Texas Health Science Center at Houston, Houston, Texas 77030; Department of Gastroenterology (L.Z.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China; Medical College of Qingdao University (C.Y.), Qingdao 266020, People's Republic of China; Department of Cancer Biology (S.A.K.), Vontz Center for Molecular Studies, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267; Department of Pathology (J.Z.), Harvard Medical School, and Department of Cancer Biology Dana-Farber Cancer Institute, Boston, Massachusetts 02115; and Department of Biomedical Research (D.J.C.), Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048.
Fang ZouChildren's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medicine, and Brown Foundation Institute of Molecular Medicine (Q.T.), University of Texas Health Science Center at Houston, Houston, Texas 77030; Department of Gastroenterology (L.Z.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China; Medical College of Qingdao University (C.Y.), Qingdao 266020, People's Republic of China; Department of Cancer Biology (S.A.K.), Vontz Center for Molecular Studies, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267; Department of Pathology (J.Z.), Harvard Medical School, and Department of Cancer Biology Dana-Farber Cancer Institute, Boston, Massachusetts 02115; and Department of Biomedical Research (D.J.C.), Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048.
Hongfang DingChildren's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medicine, and Brown Foundation Institute of Molecular Medicine (Q.T.), University of Texas Health Science Center at Houston, Houston, Texas 77030; Department of Gastroenterology (L.Z.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China; Medical College of Qingdao University (C.Y.), Qingdao 266020, People's Republic of China; Department of Cancer Biology (S.A.K.), Vontz Center for Molecular Studies, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267; Department of Pathology (J.Z.), Harvard Medical School, and Department of Cancer Biology Dana-Farber Cancer Institute, Boston, Massachusetts 02115; and Department of Biomedical Research (D.J.C.), Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048.
Chunmei WangChildren's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medicine, and Brown Foundation Institute of Molecular Medicine (Q.T.), University of Texas Health Science Center at Houston, Houston, Texas 77030; Department of Gastroenterology (L.Z.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China; Medical College of Qingdao University (C.Y.), Qingdao 266020, People's Republic of China; Department of Cancer Biology (S.A.K.), Vontz Center for Molecular Studies, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267; Department of Pathology (J.Z.), Harvard Medical School, and Department of Cancer Biology Dana-Farber Cancer Institute, Boston, Massachusetts 02115; and Department of Biomedical Research (D.J.C.), Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048.
Chunling YanChildren's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medicine, and Brown Foundation Institute of Molecular Medicine (Q.T.), University of Texas Health Science Center at Houston, Houston, Texas 77030; Department of Gastroenterology (L.Z.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China; Medical College of Qingdao University (C.Y.), Qingdao 266020, People's Republic of China; Department of Cancer Biology (S.A.K.), Vontz Center for Molecular Studies, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267; Department of Pathology (J.Z.), Harvard Medical School, and Department of Cancer Biology Dana-Farber Cancer Institute, Boston, Massachusetts 02115; and Department of Biomedical Research (D.J.C.), Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048.
Pradip SahaChildren's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medicine, and Brown Foundation Institute of Molecular Medicine (Q.T.), University of Texas Health Science Center at Houston, Houston, Texas 77030; Department of Gastroenterology (L.Z.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China; Medical College of Qingdao University (C.Y.), Qingdao 266020, People's Republic of China; Department of Cancer Biology (S.A.K.), Vontz Center for Molecular Studies, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267; Department of Pathology (J.Z.), Harvard Medical School, and Department of Cancer Biology Dana-Farber Cancer Institute, Boston, Massachusetts 02115; and Department of Biomedical Research (D.J.C.), Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048.
Sohaib A KhanChildren's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medicine, and Brown Foundation Institute of Molecular Medicine (Q.T.), University of Texas Health Science Center at Houston, Houston, Texas 77030; Department of Gastroenterology (L.Z.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China; Medical College of Qingdao University (C.Y.), Qingdao 266020, People's Republic of China; Department of Cancer Biology (S.A.K.), Vontz Center for Molecular Studies, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267; Department of Pathology (J.Z.), Harvard Medical School, and Department of Cancer Biology Dana-Farber Cancer Institute, Boston, Massachusetts 02115; and Department of Biomedical Research (D.J.C.), Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048.
Jean ZhaoChildren's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medicine, and Brown Foundation Institute of Molecular Medicine (Q.T.), University of Texas Health Science Center at Houston, Houston, Texas 77030; Department of Gastroenterology (L.Z.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China; Medical College of Qingdao University (C.Y.), Qingdao 266020, People's Republic of China; Department of Cancer Biology (S.A.K.), Vontz Center for Molecular Studies, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267; Department of Pathology (J.Z.), Harvard Medical School, and Department of Cancer Biology Dana-Farber Cancer Institute, Boston, Massachusetts 02115; and Department of Biomedical Research (D.J.C.), Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048.
Makoto FukudaChildren's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medicine, and Brown Foundation Institute of Molecular Medicine (Q.T.), University of Texas Health Science Center at Houston, Houston, Texas 77030; Department of Gastroenterology (L.Z.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China; Medical College of Qingdao University (C.Y.), Qingdao 266020, People's Republic of China; Department of Cancer Biology (S.A.K.), Vontz Center for Molecular Studies, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267; Department of Pathology (J.Z.), Harvard Medical School, and Department of Cancer Biology Dana-Farber Cancer Institute, Boston, Massachusetts 02115; and Department of Biomedical Research (D.J.C.), Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048.
Qingchun TongChildren's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medicine, and Brown Foundation Institute of Molecular Medicine (Q.T.), University of Texas Health Science Center at Houston, Houston, Texas 77030; Department of Gastroenterology (L.Z.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China; Medical College of Qingdao University (C.Y.), Qingdao 266020, People's Republic of China; Department of Cancer Biology (S.A.K.), Vontz Center for Molecular Studies, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267; Department of Pathology (J.Z.), Harvard Medical School, and Department of Cancer Biology Dana-Farber Cancer Institute, Boston, Massachusetts 02115; and Department of Biomedical Research (D.J.C.), Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048.
Deborah J CleggChildren's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medicine, and Brown Foundation Institute of Molecular Medicine (Q.T.), University of Texas Health Science Center at Houston, Houston, Texas 77030; Department of Gastroenterology (L.Z.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China; Medical College of Qingdao University (C.Y.), Qingdao 266020, People's Republic of China; Department of Cancer Biology (S.A.K.), Vontz Center for Molecular Studies, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267; Department of Pathology (J.Z.), Harvard Medical School, and Department of Cancer Biology Dana-Farber Cancer Institute, Boston, Massachusetts 02115; and Department of Biomedical Research (D.J.C.), Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048.
Lawrence ChanChildren's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medicine, and Brown Foundation Institute of Molecular Medicine (Q.T.), University of Texas Health Science Center at Houston, Houston, Texas 77030; Department of Gastroenterology (L.Z.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China; Medical College of Qingdao University (C.Y.), Qingdao 266020, People's Republic of China; Department of Cancer Biology (S.A.K.), Vontz Center for Molecular Studies, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267; Department of Pathology (J.Z.), Harvard Medical School, and Department of Cancer Biology Dana-Farber Cancer Institute, Boston, Massachusetts 02115; and Department of Biomedical Research (D.J.C.), Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048.
Yong XuChildren's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medicine, and Brown Foundation Institute of Molecular Medicine (Q.T.), University of Texas Health Science Center at Houston, Houston, Texas 77030; Department of Gastroenterology (L.Z.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China; Medical College of Qingdao University (C.Y.), Qingdao 266020, People's Republic of China; Department of Cancer Biology (S.A.K.), Vontz Center for Molecular Studies, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267; Department of Pathology (J.Z.), Harvard Medical School, and Department of Cancer Biology Dana-Farber Cancer Institute, Boston, Massachusetts 02115; and Department of Biomedical Research (D.J.C.), Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048.
Diabetes Research CenterBaylor College of Medicine · USCedars-Sinai Medical Center · USDana-Farber Cancer Institute · USHuazhong University of Science and Technology · CNQingdao University · CNThe University of Texas Health Science Center at Houston · USUniversity of Cincinnati Medical Center · US
Funding
Novel Mechanisms Regulating the Adipocyte-Brain-Hepatocyte AxisP01DK088761 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI SCHERER, PHILIPP E · 2010 to 2019
$17.4MCenter for Clinical and Translational Sciences (CCTS)UL1TR000371 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2012 to 2016
$13.4MInitiative for Maximizing Student Development (IMSD) ProgramR25GM056929 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI PEREIRA, FRED A · 1998 to 2023
$12.4MDiabetes Endocrinology Research CenterP30DK079638 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI CHAN, LAWRENCE · 2008 to 2012
$6.4MMODELS FOR ATHEROSCLEROSIS RESEARCHR01HL051586 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI CHAN, LAWRENCE · 1994 to 2014
$5.5MREGULATION OF CELLULAR GROWTH AND DIFFERENTIATIONT32CA059268 · NCI · UNIVERSITY OF CINCINNATI · PI KHAN, SOHAIB A. · 1993 to 2010
$2.3MSim1 Neurons and Body Weight RegulationR01DK092605 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI TONG, QINGCHUN · 2012 to 2016
$1.7MCNS Circuits Mediating Estrogenic Regulation on Energy and Glucose HomeostasisR01DK093587 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI XU, YONG · 2011 to 2015
$1.6MCentral Role of Gut Hormone GIP in Leptin Resistance and ObesityR01DK104901 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI FUKUDA, MAKOTO · 2015 to 2019
$1.6MTargeting hypothalamic steroid receptor co-activator-1 to treat obesityR01DK101379 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI XU, YONG · 2014 to 2017
$1.2MHypothalamic mechanisms mediating estrogenic regulation of energy homeostasisR00DK085330 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI XU, YONG · 2010 to 2012
$742kNCATS NIH HHS UL1 TR000371NCI NIH HHS T32 CA059268NCI NIH HHS T32CA059268NHLBI NIH HHS HL051586NHLBI NIH HHS R01 HL051586NIDDK NIH HHS DK105527NIDDK NIH HHS P01 DK088761NIDDK NIH HHS P30 DK079638NIDDK NIH HHS P30 DK079638-03NIDDK NIH HHS R00 DK085330NIDDK NIH HHS R00DK085330NIDDK NIH HHS R01 DK092605NIDDK NIH HHS R01DK092605NIDDK NIH HHS R01 DK093587NIDDK NIH HHS R01DK093587NIDDK NIH HHS R01 DK101379NIDDK NIH HHS R01DK101379NIDDK NIH HHS R01 DK104901NIGMS NIH HHS R25 GM056929
Abstract
Estrogens act upon estrogen receptor (ER)α to inhibit feeding and improve glucose homeostasis in female animals. However, the intracellular signals that mediate these estrogenic actions remain unknown. Here, we report that anorexigenic effects of estrogens are blunted in female mice that lack ERα specifically in proopiomelanocortin (POMC) progenitor neurons. These mutant mice also develop insulin resistance and are insensitive to the glucose-regulatory effects of estrogens. Moreover, we showed that propyl pyrazole triol (an ERα agonist) stimulates the phosphatidyl inositol 3-kinase (PI3K) pathway specifically in POMC progenitor neurons, and that blockade of PI3K attenuates propyl pyrazole triol-induced activation of POMC neurons. Finally, we show that effects of estrogens to inhibit food intake and to improve insulin sensitivity are significantly attenuated in female mice with PI3K genetically inhibited in POMC progenitor neurons. Together, our results indicate that an ERα-PI3K cascade in POMC progenitor neurons mediates estrogenic actions to suppress food intake and improve insulin sensitivity.
Indexed as
Insulin ResistanceAnimalsBlood GlucoseEatingEstrogen Receptor alphaEstrogensFeeding BehaviorFemaleGlucoseHomeostasisMiceMice, KnockoutNeural Stem CellsNeuronsPhenolsPhosphatidylinositol 3-Kinase4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenolBlood GlucoseEstrogen Receptor alphaEstrogensGlucosePhenolsPhosphatidylinositol 3-KinasePro-OpiomelanocortinPyrazoles
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.