SynthesisSurgical infections2016
Component Separation vs. Bridged Repair for Large Ventral Hernias: A Multi-Institutional Risk-Adjusted Comparison, Systematic Review, and Meta-Analysis.
Synthesis in Surgical infections, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 124 citations in OpenAlex.
- Robotic-assisted primary ventral and incisional hernia repair: a comprehensive comparative analysis of rv-TAPP, r-Rives, and r-TARUP techniques.Journal of robotic surgery · 2025Pooled it
- Identifying predictors of ventral hernia recurrence: systematic review and meta-analysis.BJS open · 2021Pooled it
- A systematic methodological review of reported perioperative variables, postoperative outcomes and hernia recurrence from randomised controlled trials of elective ventral hernia repair: clear definitions and standardised datasets are needed.Hernia : the journal of hernias and abdominal wall surgery · 2018Pooled it
- The impact of component separation technique versus no component separation technique on complications and quality of life in the repair of large ventral hernias.Surgical endoscopy · 2020Trial
- Figure-of-eights vs running suture for fascial closure of large ventral hernias: do figure-of-eights induce ischemia?Surgical endoscopy · 2026Article
- Ultrasound alone is sufficient: no added value of electromyography in botulinum toxin prehabilitation for complex ventral hernias?Hernia : the journal of hernias and abdominal wall surgery · 2026Observational
- An Analysis of Biomechanical and Physiological Changes During Abdominal Wall Reconstruction.Journal of abdominal wall surgery : JAWS · 2026Article
- Preoperative Botulinum Toxin A (BTA) injection in abdominal wall reconstruction for subxiphoid (M1) hernias.Hernia : the journal of hernias and abdominal wall surgery · 2025Article
- Review
- Achieving fascial closure with preoperative botulinum toxin injections in abdominal wall reconstruction: outcomes from a high-volume center.Updates in surgery · 2024Article
- The outcomes of component separation technique versus no component separation technique in the repair of large ventral hernias and impact on quality of life: a multicenter retrospective cohort study.Annals of surgical treatment and research · 2024Article
- Management of Massive Flank Hernia After Lateral Lumbar Fusion: Preoperative Botulinum Toxin Injections and Open Repair - A Case Report.The American journal of case reports · 2024Article
- Volumetry after botulinum toxin A: the impact on abdominal wall compliance and endotracheal pressure.Hernia : the journal of hernias and abdominal wall surgery · 2024Article
- The open abdomen in trauma, acute care, and vascular and endovascular surgery: comprehensive, expert, narrative review.BJS open · 2023Review
- Preservation of deep epigastric perforators during anterior component separation technique (ACST) results in equivalent wound complications compared to transversus abdominis release (TAR).Hernia : the journal of hernias and abdominal wall surgery · 2023Article
- Reading a preoperative CT scan to guide complex abdominal wall reconstructive surgery.Hernia : the journal of hernias and abdominal wall surgery · 2023Article
- A computed tomography study investigating the effects of botulinum toxin injections prior to complex abdominal wall reconstruction.Hernia : the journal of hernias and abdominal wall surgery · 2023Article
- Traumatic abdominal wall hernia and Morel-Lavallee lesion in a pediatric patient.Proceedings (Baylor University. Medical Center) · 2023Article
- Is There Indication for the Use of Biological Mesh in Cancer Patients?Journal of clinical medicine · 2022Article
- Bridged repair of large ventral hernia defects using an ovine reinforced biologic: A case series.Annals of medicine and surgery (2012) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundRepair of large ventral hernia defects is associated with high rates of surgical site occurrences (SSO), including surgical site infection (SSI), site dehiscence, seroma, hematoma, and site necrosis. Two common operative strategies exist: Component separation (CS) with primary fascial closure and mesh reinforcement (PFC-CS) and bridged repair (mesh spanning the hernia defect). We hypothesized that: (1) ventral hernia repair (VHR) of large defects with bridged repair is associated with more SSOs than is PFC, and (2) anterior CS is associated with more SSOs than is endoscopic, perforator-sparing, or posterior CS.
methodsPart I of this study was a review of a multi-center database of patients who underwent VHR of a defect ≥8 cm from 2010-2011 with at least one month of follow-up. The primary outcome was SSO. The secondary outcome was recurrence. Part II of this study was a systematic review and meta-analysis of studies comparing bridged repair with PFC and studies comparing different kinds of CS.
resultsA total of 108 patients were followed for a median of 16 months (range 1-50 months), of whom 84 underwent PFC-CS and 24 had bridged repairs. Unadjusted results demonstrated no differences between the groups in SSO or recurrence; however, the study was underpowered for this purpose. On meta-analysis, PFC was associated with a lower risk of SSO (odds ratio [OR] = 0.569; 95% confidence interval [CI] = 0.34-0.94) and recurrence (OR = 0.138; 95% CI = 0.08-0.23) compared with bridged repair. On multiple-treatments meta-analysis, both endoscopic and perforator-sparing CS were most likely to be the treatments with the lowest risk of SSO and recurrence.
conclusionsBridged repair was associated with more SSOs than was PFC, and PFC should be used whenever feasible. Endoscopic and perforator-sparing CS were associated with the fewest complications; however, these conclusions are limited by heterogeneity between studies and poor methodological quality. These results should be used to guide future trials, which should compare the risks and benefits of each CS method to determine in which setting each technique will give the best results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.