Evidence map›Paper›PMID 26375241›Full record

ReviewProgress in neuro-psychopharmacology & biological psychiatry2016

Opposing effects of alcohol on the immune system.

Tasha Barr, Christa Helms, Kathleen Grant, Ilhem Messaoudi

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Progress in neuro-psychopharmacology & biological psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 139 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
139citing papers in PubMed, 2 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

139 citing papers in PubMed, 2 syntheses or guidelines pooled it, 268 citations in OpenAlex.

  1. Inflammatory cytokines and alcohol use disorder: systematic review and meta-analysis.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2022
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79 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Tasha BarrDivision of Biomedical Sciences, School of Medicine, University of California-Riverside, Riverside, CA 92521, USA.
Christa HelmsDivision of Neurosciences, Oregon National Primate Center, Oregon Health and Science University, Beaverton, OR 97006, USA.
Kathleen GrantDivision of Neurosciences, Oregon National Primate Center, Oregon Health and Science University, Beaverton, OR 97006, USA.
Ilhem MessaoudiDivision of Biomedical Sciences, School of Medicine, University of California-Riverside, Riverside, CA 92521, USA. Electronic address: ilhem.messaoudi@ucr.edu.
Oregon National Primate Research Center · USUniversity of California, Riverside · US

Funding

Stress and Ethanol Self-Administration in MonkeysU01AA013510 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KATHLEEN A GRANT · 2002 to 2026
$11.8M
Monkey Alcohol Tissue Research Resource (MATRR)R24AA019431 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Mary Lauren Benton, Verginia Carmella Cuzon Carlson · 2010 to 2026
$10.3M
Research Training in Environmental ToxicologyT32ES018827 · NIEHS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI Yinsheng Wang · 2010 to 2026
$5.3M
Impact of chronic ethanol self administration on T cellR21AA021947 · NIAAA · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI MESSAOUDI, ILHEM · 2013 to 2014
$394k
Molecular mechanisms of ethanol-mediated dysregulation of gut homeostasisR21AA024981 · NIAAA · UNIVERSITY OF CALIFORNIA-IRVINE · PI MESSAOUDI, ILHEM · 2016 to 2017
$388k
NIAAA NIH HHS AA013510NIAAA NIH HHS AA021947NIAAA NIH HHS AA109431NIAAA NIH HHS R21 AA021947NIAAA NIH HHS R21 AA024981NIAAA NIH HHS R24 AA019431NIAAA NIH HHS U01 AA013510NIEHS NIH HHS T32 ES018827
6 · The paper itself

Abstract

Several studies have described a dose-dependent effect of alcohol on human health with light to moderate drinkers having a lower risk of all-cause mortality than abstainers, while heavy drinkers are at the highest risk. In the case of the immune system, moderate alcohol consumption is associated with reduced inflammation and improved responses to vaccination, while chronic heavy drinking is associated with a decreased frequency of lymphocytes and increased risk of both bacterial and viral infections. However, the mechanisms by which alcohol exerts a dose-dependent effect on the immune system remain poorly understood due to a lack of systematic studies that examine the effect of multiple doses and different time courses. This review will summarize our current understanding of the impact of moderate versus excessive alcohol consumption on the innate and adaptive branches of the immune system derived from both in vitro as well as in vivo studies carried out in humans and animal model studies.

Indexed as

Alcohol-Related DisordersAnimalsCentral Nervous System DepressantsEthanolHumansImmune SystemCentral Nervous System DepressantsEthanolAlcoholGene expressionGlucocorticoidHPA axisImmunityInfectionInflammationVaccination

Identifiers

PMID26375241
PMCPMC4911891
OpenAlexW1650799242

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.