Observational studyAnais brasileiros de dermatologia
Clinicopathological profile and management of 161 cases of actinic cheilitis.
Observational study in Anais brasileiros de dermatologia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Clinicopathological Analysis of Actinic Cheilitis: A Systematic Review with Meta-analyses.Head and neck pathology · 2023Pooled it
- Daylight photodynamic therapy for the management of actinic cheilitis.Archives of dermatological research · 2020Trial
- Article
- Randomized Clinical Trial of Conventional versus Indoor Daylight Photodynamic Therapy for Treatment of Actinic Cheilitis.Dermatology and therapy · 2022Article
- Actinic cheilitis: Proposal of a clinical index.Medicina oral, patologia oral y cirugia bucal · 2022Article
- Actinic cheilitis or squamous cell carcinoma of the lip? Practical recommendations on how to avoid a trap.Revista da Associacao Medica Brasileira (1992) · 2022Article
- Immunoexpression of PD-L1, CD4+ and CD8+ cell infiltrates and tumor-infiltrating lymphocytes (TILs) in the microenvironment of actinic cheilitis and lower lip squamous cell carcinoma.Journal of applied oral science : revista FOB · 2022Article
- Actinic Cheilitis - From Risk Factors to Therapy.Frontiers in medicine · 2022Review
- Treatment Options and Post-Treatment Malignant Transformation Rate of Actinic Cheilitis: A Systematic Review.Cancers · 2021Review
- Demographic and Clinicopathologic Features of Actinic Cheilitis and Lip Squamous Cell Carcinoma: a Brazilian Multicentre Study.Head and neck pathology · 2020Article
- In Vivo Reflectance Confocal Microscopy-Diagnostic Criteria for Actinic Cheilitis and Squamous Cell Carcinoma of the Lip.Journal of clinical medicine · 2020Article
- Fludroxycortide cream as an alternative therapy for actinic cheilitis.Clinical oral investigations · 2019Article
- Actinic cheilitis and lip squamous cell carcinoma: Literature review and new data from Brazil.Journal of clinical and experimental dentistry · 2019Review
- Non-invasive imaging of actinic cheilitis and squamous cell carcinoma of the lip.Molecular and clinical oncology · 2018Article
- Diclofenac sodium gel therapy as an alternative to actinic cheilitis.Clinical oral investigations · 2018Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundActinic cheilitis (AC) is a potentially malignant disorder of the lip caused by chronic exposure to ultraviolet radiation from the sun.
objectivesTo evaluate the clinical, demographic, morphological and therapeutic management in AC cases data associating to the histopathological grading.
methodsDemographic, clinical and management data of 161 patients with AC were analyzed. In biopsied cases, two calibrated examiners performed histopathological grading by binary system.
resultsThere was a prevalence of males (79.5%), aged 40 years or older (77.5%), light-skinned (85.7%), experiencing occupational exposure to sunlight (80.3%), with AC presenting clinically as white lesions (33.6%). Conservative treatment was adopted in 78 cases and biopsy in 83 cases (60.2% graded as low-risk AC). There were no significant associations between histopathological grading and gender (p= 0.509), age (p=0.416), ethnicity (p=0.388), occupational exposure to sunlight (p=1.000) or clinical presentation (p=0.803).
conclusionThis study reinforces the hypothesis that demographic and clinical characteristics of AC are not related to histopathological grading. Advice on protection from sun exposure should be encouraged to avoid progression of AC and invasive therapies.
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Registered trials
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