ArticleNature2015
Single cell activity reveals direct electron transfer in methanotrophic consortia.
Article in Nature, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 239 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
239 citing papers in PubMed, 1 synthesis or guideline pooled it, 659 citations in OpenAlex.
- The microbial dark matter and "wanted list" in worldwide wastewater treatment plants.Microbiome · 2023Pooled it
- Cellulose-fueled extracellular electron transfer in termite gut microbes.Applied and environmental microbiology · 2026Article
- Application and Mechanisms of Biochar in Anaerobic Digestion: Towards Process Resilience and Waste Valorization.Toxics · 2026Review
- Diversification in ANME-1 archaea is associated with the presence of highly variable genomic hotspots.Nature communications · 2026Article
- Biophotocatalytic and bioelectrocatalytic strategies for methane production and oxidation: emerging pathways and perspectives.Archives of microbiology · 2026Review
- Carbon monoxide oxidation expands the known metabolic capacity in anaerobic methanotrophic consortia.Nature communications · 2026Article
- Microbially driven methane and sulfur cycling processes and coupling mechanisms in mangrove sediments.Environmental microbiome · 2026Article
- Review
- Mechanisms of Direct Electron Transfer Governed by Redox-Active Conductive Carrier with Superior Wettability in Anaerobic Biofilms.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Influence of cell-cell distance on the ecology and evolution of microbial communities.The ISME journal · 2026Review
- Viral communities from long-term anaerobic alkane-oxidizing enrichment cultures encode predicted cell surface adhesion functions.The ISME journal · 2026Article
- Alkane-oxidizing consortia produce substantial amounts of disaccharides.Frontiers in microbiology · 2026Article
- Anaerobic oxidation of methane supports a minimal microbial community in a subsurface biofilm at Ginsburg mud volcano.ISME communications · 2026Article
- Substrate toxicity drives successive range expansions opposing spatial intermixing in cross-feeding consortia.ISME communications · 2026Article
- Potential for Manganese Oxide Driven Anaerobic Methane Oxidation in Sediments of a Seasonally Euxinic Coastal Basin.Estuaries and coasts : journal of the Estuarine Research Federation · 2026Article
- Beyond Methane Oxidation: The Protein Landscape of ANME-2a Reveals an Integrated System for Diazotrophy and Membrane Fortification.Environmental microbiology reports · 2025Article
- Marine Cold Seep ANME-2/SRB Consortia Produce Their Lipid Biomass From Inorganic Carbon.Environmental microbiology · 2025Article
- Redox conduction facilitates direct interspecies electron transport in anaerobic methanotrophic consortia.Science advances · 2025Article
- Methanotrophic Flexibility of 'Ca. Methanoperedens' and Its Interactions With Sulphate-Reducing Bacteria in the Sediment of Meromictic Lake Cadagno.Environmental microbiology · 2025Article
- Non-Respiratory Extracellular Electron Transfer Competes with Nitrogenase for Electrons in Rhodopseudomonas Palustris.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
179 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multicellular assemblages of microorganisms are ubiquitous in nature, and the proximity afforded by aggregation is thought to permit intercellular metabolic coupling that can accommodate otherwise unfavourable reactions. Consortia of methane-oxidizing archaea and sulphate-reducing bacteria are a well-known environmental example of microbial co-aggregation; however, the coupling mechanisms between these paired organisms is not well understood, despite the attention given them because of the global significance of anaerobic methane oxidation. Here we examined the influence of interspecies spatial positioning as it relates to biosynthetic activity within structurally diverse uncultured methane-oxidizing consortia by measuring stable isotope incorporation for individual archaeal and bacterial cells to constrain their potential metabolic interactions. In contrast to conventional models of syntrophy based on the passage of molecular intermediates, cellular activities were found to be independent of both species intermixing and distance between syntrophic partners within consortia. A generalized model of electric conductivity between co-associated archaea and bacteria best fit the empirical data. Combined with the detection of large multi-haem cytochromes in the genomes of methanotrophic archaea and the demonstration of redox-dependent staining of the matrix between cells in consortia, these results provide evidence for syntrophic coupling through direct electron transfer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.