Evidence map›Paper›PMID 26374997›Full record

ArticleNature2015

Nanoparticle biointerfacing by platelet membrane cloaking.

Che-Ming J Hu, Ronnie H Fang, Kuei-Chun Wang, Brian T Luk, Soracha Thamphiwatana, Diana Dehaini, Phu Nguyen, Pavimol Angsantikul, Cindy H Wen, Ashley V Kroll and 12 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05978791 (Study on the Thrombolytic Effect of Platelet Membrane Coated Recombinant Staphylokinase on Human Arterial Thrombus), which is not on this map. Cited by 700 papers.

0numbers the graph read from it
0cells of the map it votes in
700citing papers in PubMed
67.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05978791 unknown statusnot on this mapstarted 2023, after this paper: background citation

Study on the Thrombolytic Effect of Platelet Membrane Coated Recombinant Staphylokinase on Human Arterial Thrombus

TypeobservationalSponsorThe First Affiliated Hospital with Nanjing Medical UniversityRan2023 to 2024Enrolled24ConditionsArterial ThrombosisArmscollection of venous blood or arterial blood
3 · Its place in the literature

Who cites it

700 citing papers in PubMed, 1,736 citations in OpenAlex.

  1. Article
  2. Materials today. Bio · 2026
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  16. Platelet Products and Artificial Platelets for Regenerative Medicine.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2026
    Review
  17. Review
  18. Review
  19. Article
  20. Biolipid Film-Fused Electrochemiluminescence for Multipurpose In Situ Bioassays.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article

640 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 2 institutions in 1 country.

Che-Ming J HuDepartment of NanoEngineering, University of California, San Diego, La Jolla, California 92093, USA.
Ronnie H FangDepartment of NanoEngineering, University of California, San Diego, La Jolla, California 92093, USA.
Kuei-Chun WangDepartment of Bioengineering, University of California, San Diego, La Jolla, California 92093, USA.
Brian T LukMoores Cancer Center, University of California, San Diego, La Jolla, California 92093, USA.
Soracha ThamphiwatanaDepartment of NanoEngineering, University of California, San Diego, La Jolla, California 92093, USA.
Diana DehainiDepartment of NanoEngineering, University of California, San Diego, La Jolla, California 92093, USA.
Phu NguyenDepartment of Bioengineering, University of California, San Diego, La Jolla, California 92093, USA.
Pavimol AngsantikulDepartment of NanoEngineering, University of California, San Diego, La Jolla, California 92093, USA.
Cindy H WenShiley Eye Institute, University of California, San Diego, La Jolla, California 92093, USA.
Ashley V KrollDepartment of NanoEngineering, University of California, San Diego, La Jolla, California 92093, USA.
Cody CarpenterDepartment of NanoEngineering, University of California, San Diego, La Jolla, California 92093, USA.
Manikantan RameshDepartment of NanoEngineering, University of California, San Diego, La Jolla, California 92093, USA.
Vivian QuDepartment of NanoEngineering, University of California, San Diego, La Jolla, California 92093, USA.
Sherrina H PatelShiley Eye Institute, University of California, San Diego, La Jolla, California 92093, USA.
Jie ZhuShiley Eye Institute, University of California, San Diego, La Jolla, California 92093, USA.
William ShiShiley Eye Institute, University of California, San Diego, La Jolla, California 92093, USA.
Florence M HofmanDepartment of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.
Thomas C ChenDepartment of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.
Weiwei GaoDepartment of NanoEngineering, University of California, San Diego, La Jolla, California 92093, USA.
Kang ZhangDepartment of NanoEngineering, University of California, San Diego, La Jolla, California 92093, USA.
Shu ChienDepartment of Bioengineering, University of California, San Diego, La Jolla, California 92093, USA.
Liangfang ZhangDepartment of NanoEngineering, University of California, San Diego, La Jolla, California 92093, USA.
University of California, San Diego · USUniversity of Southern California · US

Funding

Systems Biology Analyses for Hemodynamic Regulation of Vascular HomeostasisR01HL108735 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHIEN, SHU, SHYY, JOHN YJ · 2012 to 2024
$13.4M
Limbal Stem Cell Fate and Corneal Specific EnhancersR01EY025090 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SEN, GEORGE L, ZHANG, KANG · 2015 to 2018
$1.9M
UCSD Cancer Nanotechnology Training CenterR25CA153915 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KUMMEL, ANDREW CLYDE, MATTREY, ROBERT F · 2010 to 2014
$1.8M
Innate Antimicrobial Nanotherapeutics for the Treatment of H. pylori InfectionR01DK095168 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZHANG, LIANGFANG · 2012 to 2016
$1.6M
Chemical Biology Interfaces at UC San DiegoT32GM112584 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BURKART, MICHAEL D. · 2015 to 2019
$729k
NCI NIH HHS R25 CA153915NCI NIH HHS R25CA153915NEI NIH HHS R01 EY025090NEI NIH HHS R01EY25090NHLBI NIH HHS R01 HL108735NHLBI NIH HHS R01HL108735NIDDK NIH HHS R01 DK095168NIDDK NIH HHS R01DK095168NIGMS NIH HHS T32 GM112584
6 · The paper itself

Abstract

Development of functional nanoparticles can be encumbered by unanticipated material properties and biological events, which can affect nanoparticle effectiveness in complex, physiologically relevant systems. Despite the advances in bottom-up nanoengineering and surface chemistry, reductionist functionalization approaches remain inadequate in replicating the complex interfaces present in nature and cannot avoid exposure of foreign materials. Here we report on the preparation of polymeric nanoparticles enclosed in the plasma membrane of human platelets, which are a unique population of cellular fragments that adhere to a variety of disease-relevant substrates. The resulting nanoparticles possess a right-side-out unilamellar membrane coating functionalized with immunomodulatory and adhesion antigens associated with platelets. Compared to uncoated particles, the platelet membrane-cloaked nanoparticles have reduced cellular uptake by macrophage-like cells and lack particle-induced complement activation in autologous human plasma. The cloaked nanoparticles also display platelet-mimicking properties such as selective adhesion to damaged human and rodent vasculatures as well as enhanced binding to platelet-adhering pathogens. In an experimental rat model of coronary restenosis and a mouse model of systemic bacterial infection, docetaxel and vancomycin, respectively, show enhanced therapeutic efficacy when delivered by the platelet-mimetic nanoparticles. The multifaceted biointerfacing enabled by the platelet membrane cloaking method provides a new approach in developing functional nanoparticles for disease-targeted delivery.

Indexed as

Platelet AdhesivenessAnimalsAnti-Bacterial AgentsBlood PlateletsBlood VesselsCell MembraneCollagenComplement ActivationCoronary RestenosisDisease Models, AnimalDocetaxelDrug Delivery SystemsHumansMacrophagesMaleMiceAnti-Bacterial AgentsCollagenDocetaxelPolymersTaxoidsUnilamellar LiposomesVancomycin

Identifiers

PMID26374997
PMCPMC4871317
OpenAlexW2190141802

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.