ArticleHuman brain mapping2015
Gyrification brain abnormalities as predictors of outcome in anorexia nervosa.
Article in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Cortical complexity in eating disorders: a systematic review and qualitative synthesis.European archives of psychiatry and clinical neuroscience · 2026Pooled it
- Brain networks in eating disorders: a systematic review of graph theory studies.Eating and weight disorders : EWD · 2022Pooled it
- Brain morphological changes in adolescent and adult patients with anorexia nervosa.Journal of neural transmission (Vienna, Austria : 1996) · 2016Pooled it
- Cortical gyrification predicts initial treatment response in adults with ADHD.Translational psychiatry · 2025Trial
- Clinical staging for eating disorders: A scoping review and update.European psychiatry : the journal of the Association of European Psychiatrists · 2026Article
- Weight gained during treatment predicts 6-month body mass index in a large sample of patients with anorexia nervosa using ensemble machine learning.The International journal of eating disorders · 2024Article
- Lower region-specific gray matter volume in females with atypical anorexia nervosa and anorexia nervosa.The International journal of eating disorders · 2024Article
- Cortical folding correlates to aging and Alzheimer's Disease's cognitive and CSF biomarkers.Scientific reports · 2024Article
- Examining the relationship between autistic spectrum disorder characteristics and structural brain differences seen in anorexia nervosa.European eating disorders review : the journal of the Eating Disorders Association · 2022Article
- The sight of one's own body: Could qEEG help predict the treatment response in anorexia nervosa?Frontiers in psychology · 2022Article
- Volumetric Alterations of the Cerebral Cortex in Eating Disorders.Journal of clinical medicine · 2021Article
- Clinical and Cognitive Functioning Changes After Partial Hospitalization in Patients With Anorexia Nervosa.Frontiers in psychiatry · 2021Article
- Age influences structural brain restoration during weight gain therapy in anorexia nervosa.Translational psychiatry · 2020Article
- Cortical Complexity in Anorexia Nervosa: A Fractal Dimension Analysis.Journal of clinical medicine · 2020Article
- Cortical morphometry in anorexia nervosa: An out-of-sample replication study.European eating disorders review : the journal of the Eating Disorders Association · 2019Article
- Article
- Development of the cerebral cortex and the effect of the intrauterine environment.The Journal of physiology · 2018Review
- Structural Neuroimaging of Anorexia Nervosa: Future Directions in the Quest for Mechanisms Underlying Dynamic Alterations.Biological psychiatry · 2018Review
- Evidence for alterations of cortical folding in anorexia nervosa.European archives of psychiatry and clinical neuroscience · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gyrification brain abnormalities are considered a marker of early deviations from normal developmental trajectories and a putative predictor of poor outcome in psychiatric disorders. The aim of this study was to explore cortical folding morphology in patients with anorexia nervosa (AN). A MRI brain study was conducted on 38 patients with AN, 20 fully recovered patients, and 38 healthy women. Local gyrification was measured with procedures implemented in FreeSurfer. Vertex-wise comparisons were carried out to compare: (1) AN patients and healthy women; (2) patients with a full remission at a 3-year longitudinal follow-up assessment and patients who did not recover. AN patients exhibited significantly lower gyrification when compared with healthy controls. Patients with a poor 3-year outcome had significantly lower baseline gyrification when compared to both healthy women and patients with full recovery at follow-up, even after controlling for the effects of duration of illness and gray matter volume. No significant correlation has been found between gyrification, body mass index, amount of weight loss, onset age, and duration of illness. Brain gyrification significantly predicted outcome at follow-up even after controlling for the effects of duration of illness and other clinical prognostic factors. Although the role of starvation in determining our findings cannot be excluded, our study showed that brain gyrification might be a predictor of outcome in AN. Further studies are needed to understand if brain gyrification abnormalities are indices of early neurodevelopmental alterations, the consequence of starvation, or the interaction between both factors.
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