ReviewCurrent obesity reports2015
Recent Progress in the Understanding of Obesity: Contributions of Genome-Wide Association Studies.
Review in Current obesity reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Common Variants in Lipid Metabolism-Related Genes Associate with Fat Mass Changes in Response to Dietary Monounsaturated Fatty Acids in Adults with Abdominal Obesity.The Journal of nutrition · 2019Trial
- Identification of a specific set of genes predicting obesity before phenotype appearance.iScience · 2025Article
- Sperm as a Carrier of Genome Instability in Relation to Paternal Lifestyle and Nutritional Conditions.Nutrients · 2022Article
- Capturing functional epigenomes for insight into metabolic diseases.Molecular metabolism · 2020Review
- Transgenerational transmission of hedonic behaviors and metabolic phenotypes induced by maternal overnutrition.Translational psychiatry · 2018Article
- Dietary Fatty Acid Composition Modulates Obesity and Interacts with Obesity-Related Genes.Lipids · 2017Review
- A combined linkage and association strategy identifies a variant near the GSTP1 gene associated with BMI in the Mexican population.Journal of human genetics · 2017Article
- Developmental Origins of Common Disease: Epigenetic Contributions to Obesity.Annual review of genomics and human genetics · 2016Review
- Low AMY1 Gene Copy Number Is Associated with Increased Body Mass Index in Prepubertal Boys.PloS one · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since 2007, discovery of genetic variants associated with general obesity and fat distribution has advanced tremendously through genome-wide association studies (GWAS). Currently, the number of robustly associated loci is 190. Even though these loci explain <3 % of the variance, they have provided us a still emerging picture of genomic localization, frequency and effect size spectra, and hints of functional implications. The translation into biological knowledge has turned out to be an immense task. However, in silico enrichment analyses of genes involved in specific pathways or expressed in specific tissues have the power to suggest biological mechanisms underlying obesity. Inspired by this, we highlight genes in five loci potentially mechanistically linked to leptin-receptor trafficking and signaling in primary cilia. The clinical application of genetic knowledge as prediction, prevention, or treatment strategies is unfortunately still far from reality. Thus, despite major advances, further research is warranted to solve one of the greatest health problems in modern society.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.