Evidence map›Paper›PMID 26374350›Full record

ArticleThe international journal of neuropsychopharmacology2015

Insulin-Like Growth Factor I Produces an Antidepressant-Like Effect and Elicits N-Methyl-D-Aspartate Receptor Independent Long-Term Potentiation of Synaptic Transmission in Medial Prefrontal Cortex and Hippocampus.

Jeffrey Burgdorf, Xiao-lei Zhang, Elizabeth M Colechio, Nayereh Ghoreishi-Haack, Amanda Gross, Roger A Kroes, Patric K Stanton, Joseph R Moskal

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of neuropsychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
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  9. Cross-species evidence from human and rat brain transcriptome for growth factor signaling pathway dysregulation in major depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jeffrey BurgdorfFalk Center for Molecular Therapeutics, Department of Biomedical Engineering, Northwestern University, Evanston, IL (Drs Burgdorf and Moskal); Department of Cell Biology & Anatomy, New York Medical College, Valhalla, NY (Drs Zhang and Stanton); Naurex Inc., Evanston, IL (Dr Colechio, Mrs Ghoreishi-Haack, Dr Gross, Dr Kroes, and Dr Moskal). j-burgdorf@northwestern.edu.
Xiao-lei ZhangFalk Center for Molecular Therapeutics, Department of Biomedical Engineering, Northwestern University, Evanston, IL (Drs Burgdorf and Moskal); Department of Cell Biology & Anatomy, New York Medical College, Valhalla, NY (Drs Zhang and Stanton); Naurex Inc., Evanston, IL (Dr Colechio, Mrs Ghoreishi-Haack, Dr Gross, Dr Kroes, and Dr Moskal).
Elizabeth M ColechioFalk Center for Molecular Therapeutics, Department of Biomedical Engineering, Northwestern University, Evanston, IL (Drs Burgdorf and Moskal); Department of Cell Biology & Anatomy, New York Medical College, Valhalla, NY (Drs Zhang and Stanton); Naurex Inc., Evanston, IL (Dr Colechio, Mrs Ghoreishi-Haack, Dr Gross, Dr Kroes, and Dr Moskal).
Nayereh Ghoreishi-HaackFalk Center for Molecular Therapeutics, Department of Biomedical Engineering, Northwestern University, Evanston, IL (Drs Burgdorf and Moskal); Department of Cell Biology & Anatomy, New York Medical College, Valhalla, NY (Drs Zhang and Stanton); Naurex Inc., Evanston, IL (Dr Colechio, Mrs Ghoreishi-Haack, Dr Gross, Dr Kroes, and Dr Moskal).
Amanda GrossFalk Center for Molecular Therapeutics, Department of Biomedical Engineering, Northwestern University, Evanston, IL (Drs Burgdorf and Moskal); Department of Cell Biology & Anatomy, New York Medical College, Valhalla, NY (Drs Zhang and Stanton); Naurex Inc., Evanston, IL (Dr Colechio, Mrs Ghoreishi-Haack, Dr Gross, Dr Kroes, and Dr Moskal).
Roger A KroesFalk Center for Molecular Therapeutics, Department of Biomedical Engineering, Northwestern University, Evanston, IL (Drs Burgdorf and Moskal); Department of Cell Biology & Anatomy, New York Medical College, Valhalla, NY (Drs Zhang and Stanton); Naurex Inc., Evanston, IL (Dr Colechio, Mrs Ghoreishi-Haack, Dr Gross, Dr Kroes, and Dr Moskal).
Patric K StantonFalk Center for Molecular Therapeutics, Department of Biomedical Engineering, Northwestern University, Evanston, IL (Drs Burgdorf and Moskal); Department of Cell Biology & Anatomy, New York Medical College, Valhalla, NY (Drs Zhang and Stanton); Naurex Inc., Evanston, IL (Dr Colechio, Mrs Ghoreishi-Haack, Dr Gross, Dr Kroes, and Dr Moskal).
Joseph R MoskalFalk Center for Molecular Therapeutics, Department of Biomedical Engineering, Northwestern University, Evanston, IL (Drs Burgdorf and Moskal); Department of Cell Biology & Anatomy, New York Medical College, Valhalla, NY (Drs Zhang and Stanton); Naurex Inc., Evanston, IL (Dr Colechio, Mrs Ghoreishi-Haack, Dr Gross, Dr Kroes, and Dr Moskal).
New York Medical College · USNorthwestern University · US

Funding

Presynaptic Mechanisms of Long-Term DepressionR01NS044421 · NINDS · YESHIVA UNIVERSITY · PI STANTON, PATRIC K. · 2003 to 2012
$3.0M
IGFI and DepressionR01MH094835 · NIMH · NORTHWESTERN UNIVERSITY · PI BURGDORF, JEFFREY SCOTT · 2012 to 2016
$1.9M
PRESYNAPTIC LONG-TERM SYNAPTIC DEPRESSIONR56NS044421 · NINDS · NEW YORK MEDICAL COLLEGE · PI STANTON, PATRIC K. · 2008 to 2008
$413k
NIMH NIH HHS MH094835NIMH NIH HHS R01 MH094835NINDS NIH HHS NS044421NINDS NIH HHS R01 NS044421NINDS NIH HHS R56 NS044421
6 · The paper itself

Abstract

backgroundGrowth factors play an important role in regulating neurogenesis and synapse formation and may be involved in regulating the antidepressant response to conventional antidepressants. To date, Insulin-like growth factor I (IGFI) is the only growth factor that has shown antidepressant properties in human clinical trials. However, its mechanism of action remains unclear.

methodsThe antidepressant-like effect of a single IV dose of IGFI was determined using a chronic unpredictable stress paradigm in the rat Porsolt, sucrose preference, novelty-induced hypophagia, and ultrasonic vocalization models. The dependence of the medial prefrontal cortex for these effects was determined by direct medial prefrontal cortex injection followed by Porsolt testing as well as IGFI receptor activation in the medial prefrontal cortex following an optimal IV antidepressant-like dose of IGFI. The effect of IGFI on synaptic transmission and long-term potentiation (LTP) of synaptic strength was assessed in the hippocampus and medial prefrontal cortex. The dependence of these effects on IGFI and AMPA receptor activation and protein synthesis were also determined.

resultsIGFI produced a rapid-acting and long-lasting antidepressant-like effect in each of the depression models. These effects were blocked by IGFI and AMPA receptor antagonists, and medial prefrontal cortex was localized. IGFI robustly increased synaptic strength in the hippocampus and medial prefrontal cortex and these effects were IGFI receptor and protein synthesis-dependent but N-methyl-d-aspartate receptor independent. IGFI also robustly facilitated hippocampal metaplasticity 24 hours postdosing.

conclusionsThese data support the conclusion that the antidepressant-like effects of IGFI are mediated by a persistent, LTP-like enhancement of synaptic strength requiring both IGFIR activation and ongoing protein synthesis.

Indexed as

AnimalsAntidepressive AgentsDose-Response Relationship, DrugHippocampusInsulin-Like Growth Factor ILong-Term PotentiationMaleMicroinjectionsOrgan Culture TechniquesPrefrontal CortexRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateSynaptic TransmissionAntidepressive Agentsinsulin-like growth factor-1, ratInsulin-Like Growth Factor IReceptors, N-Methyl-D-Aspartatedepressioninsulin-like growth factor Ilong-term potentiationLTPNMDARN-methyl-d-aspartate receptorsynaptic plasticity

Identifiers

PMID26374350
PMCPMC4772825
OpenAlexW2314045873

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.