Evidence map›Paper›PMID 26373983›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2016

Age- and sex-specific association of circulating osteocalcin with dynamic measures of glucose homeostasis.

K Y Jung, K M Kim, E J Ku, Y J Kim, D-H Lee, S H Choi, H C Jang, C S Shin, K S Park, S Lim

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Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.8field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

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  11. Screening of Deletion Variants within the GoatAnimals : an open access journal from MDPI · 2020
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  16. INSULIN RESISTANCE AND PATHOGENESIS OF POSTMENOPAUSAL OSTEOPOROSIS.Acta endocrinologica (Bucharest, Romania : 2005)
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

K Y JungDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
K M KimDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
E J KuDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
Y J KimDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
D-H LeeDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
S H ChoiDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
H C JangDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
C S ShinDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
K S ParkDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
S LimDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea. limsoo@snu.ac.kr.
Seoul National University Bundang Hospital · KRSeoul National University · KREulji University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

summaryOur study showed that serum osteocalcin levels are closely related to glucose metabolism in men of all ages and younger women. This association disappeared in postmenopausal women in which increases bone turnover rates. The association between serum osteocalcin levels and glucose homeostasis should be interpreted according to age and sex.

introductionOsteocalcin, a marker of bone formation, appears to be associated with glucose homeostasis. We investigated the age- and sex-specific association of serum osteocalcin level with variables related to glucose metabolism.

methodsThis study was based on cross-sectional analysis from 719 participants aged 20-85 years after excluding patients taking antidiabetic or antiosteoporotic drugs. The subjects were divided into four groups according to age and sex as follows: men <50 years (n = 131), men ≥50 years (n = 191), women <50 years (n = 108), and women ≥50 years (n = 279). Anthropometric and biochemical variables including insulin resistance (HOMA-IR) and β cell function (HOMA-β) from a 75-g oral glucose tolerance test, and serum 25-OH-vitamin D and parathyroid hormone levels were measured.

resultsThe serum osteocalcin level was significantly higher in women aged ≥50 years compared with women <50 years (20.4 ± 7.8 vs. 17.9 ± 6.8 ng/ml, p < 0.001), but there was no difference between men aged ≥50 years and men <50 years (16.4 ± 5.9 vs. 16.8 ± 6.0 ng/ml, p = 0.905). The participants diagnosed with diabetes had lower serum osteocalcin levels than normal or prediabetic participants. Multivariable regression analyses including HOMA-IR and HOMA-β indicated that serum osteocalcin levels had a negative and independent association with HbA1c levels in men and women aged <50 years, but not in women ≥50 years.

conclusionsLow osteocalcin levels are associated with impaired glucose metabolism in men and premenopausal women. The osteocalcin levels may be determined by factors related to bone metabolism in postmenopausal women. Our data suggest that the serum levels of osteocalcin associated with glucose homeostasis should be interpreted according to age and sex.

Indexed as

AdultAgedAged, 80 and overAgingAnthropometryBlood GlucoseCross-Sectional StudiesFemaleGlucose Tolerance TestGlycated HemoglobinHomeostasisHumansInsulin ResistanceMaleMiddle AgedOsteocalcinBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, humanOsteocalcinAgeGenderGlucose metabolismInsulin resistanceOsteocalcinβ cell function

Identifiers

PMID26373983
OpenAlexW1625364730

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.