Evidence map›Paper›PMID 26373757›Full record

ArticleEuropean radiology2016

Metastatic patterns and metastatic sites in mucosal melanoma: a retrospective study.

Gerd Grözinger, Steven Mann, Tarun Mehra, Bernhard Klumpp, Ulrich Grosse, Konstantin Nikolaou, Claus Garbe, Stephan Clasen

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Article in European radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gerd GrözingerDepartment of Diagnostic and Interventional Radiology, University hospital Tübingen, Hoppe- Seylerstr. 3, 72076, Tübingen, Germany. gerd.groezinger@med.uni-tuebingen.de.
Steven MannDepartment of Diagnostic and Interventional Radiology, University hospital Tübingen, Hoppe- Seylerstr. 3, 72076, Tübingen, Germany.
Tarun MehraDepartment of Dermatology, University hospital Tübingen, Liebermeisterstraße 25, 72076, Tübingen, Germany.
Bernhard KlumppDepartment of Diagnostic and Interventional Radiology, University hospital Tübingen, Hoppe- Seylerstr. 3, 72076, Tübingen, Germany.
Ulrich GrosseDepartment of Diagnostic and Interventional Radiology, University hospital Tübingen, Hoppe- Seylerstr. 3, 72076, Tübingen, Germany.
Konstantin NikolaouDepartment of Diagnostic and Interventional Radiology, University hospital Tübingen, Hoppe- Seylerstr. 3, 72076, Tübingen, Germany.
Claus GarbeDepartment of Dermatology, University hospital Tübingen, Liebermeisterstraße 25, 72076, Tübingen, Germany.
Stephan ClasenDepartment of Diagnostic and Interventional Radiology, University hospital Tübingen, Hoppe- Seylerstr. 3, 72076, Tübingen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesMelanomas arising from mucosa are rare and associated with a poor prognosis. This study aims to provide an analysis of metastatic pathways, time intervals, factors influencing metastatic spread and organs for distant metastases.

methodsA total of 116 patients with mucosal melanomas of different sites were included. The mean follow-up interval was 47 ± 52 months. Patients were assigned to two different metastatic pathways, either presenting loco-regional lymph node metastases as first spread or direct distant metastases. The distribution of distant metastases was assessed.

resultsTwenty-six patients presented with a pre-existing metastatic spread and were not assigned to pathways. Of the included patients, 44 developed metastases after treatment of the primary tumour; 25 patients directly developed distant metastases; 16 patients developed regional lymph node metastases prior to distant metastases. Location of the primary tumour in the upper airway or GI tract and advanced T stage were significant risk factors of direct distant metastases. Distant metastases are mainly located in the lung, the liver and non-regional lymph nodes.

conclusionsMucosal melanomas show a high rate of direct distant metastases rather than regional lymph node metastases. Thus the follow-up should always include a whole-body cross-sectional imaging in high-risk tumours. KEY POINTS: • Mucosal melanomas show a high rate of direct distant metastases. • T stage and primary location are predictors for direct distant metastases. • Distant metastases were mainly found in lung, liver and lymph nodes. • Follow-up of a high-risk mucosal melanoma should include whole-body imaging.

Indexed as

AdultAgedAged, 80 and overDisease ProgressionFemaleFollow-Up StudiesHumansLiver NeoplasmsLung NeoplasmsLymphatic MetastasisMagnetic Resonance ImagingMaleMelanomaMiddle AgedMucous MembraneNeoplasm StagingImagingMetastatic pathwayMetastatic spreadMucosal melanomaProgression

Identifiers

PMID26373757

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.