Evidence map›Paper›PMID 26373743›Full record

Trial reportWiener klinische Wochenschrift2015

Influence of a combination of probiotics on bacterial infections in very low birthweight newborns.

Zlatka Kanic, Dusanka Micetic Turk, Silva Burja, Vojko Kanic, Dejan Dinevski

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Wiener klinische Wochenschrift, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 13 pooled it
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 13 syntheses or guidelines pooled it, 44 citations in OpenAlex.

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  5. [Efficacy of probiotics in preventing late-onset sepsis in very low birth weight infants: a Meta analysis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Zlatka KanicIntensive Care Unit, Division of Paediatrics, University Medical Centre Maribor, Ljubljanska 5, 2000, Maribor, Slovenia. zlatka.kanic@guest.arnes.si.
Dusanka Micetic TurkFaculty of Medicine, University of Maribor, Maribor, Slovenia.
Silva BurjaFaculty of Medicine, University of Maribor, Maribor, Slovenia.
Vojko KanicDepartment of Cardiology and Angiology, University Medical Centre Maribor, Maribor, Slovenia.
Dejan DinevskiFaculty of Medicine, University of Maribor, Maribor, Slovenia.
University of Maribor · SIUniversity Clinical Centre Maribor · SI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLate-onset infections are an important cause of morbidity and mortality in preterm infants. The purpose of our prospective randomised study was to establish whether a combination of probiotics (Lactobacillus acidophilus, Enterococcus faecium and Bifidobacterium infantum) affects the incidence of late-onset sepsis and other infections in very low birthweight infants (birthweight under 1500 g, gestational age under 33 weeks).

methodsFrom 80 included infants, one half received probiotics (L. acidophilus, E. faecium and B. infantum) in the ratio 1.5:1:1.5, at a dose of 0.6 × 107 colony-forming units twice daily, given with the first portions of milk until discharge, whereas the other half did not.

resultsIn the group receiving probiotics, 16 children had late-onset sepsis compared with 29 in the group without probiotics; p = 0.006. The number of late-onset septic events was lower (30) in the group receiving probiotics than in the group that did not receive probiotics (69); p = 0.003. Furthermore, fewer children had at least one late-onset infection (20 infants in the group receiving probiotics compared with 32 in the group without them; p = 0.009). There were less episodes of late-onset infections in the group receiving probiotics (35) than in the group without probiotics (79); p = 0.002.

conclusionsA combination of probiotics at a low dose (1.2 × 107 colony-forming units) decreased the frequency of late-onset sepsis and other infections, as described in previous studies. In addition, children were discharged at a lower postmenstrual age. There were no side effects of probiotics reported.

Indexed as

Bacterial InfectionsFemaleHumansIncidenceInfantInfant MortalityInfant, Premature, DiseasesInfant, Very Low Birth WeightMaleProbioticsRisk FactorsSloveniaSurvival RateTreatment Outcomehospital infectionKeywordslate-onset sepsispreterm infantprobiotics

Identifiers

PMID26373743
OpenAlexW1678723351

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.