Evidence map›Paper›PMID 26373553›Full record

ArticleJournal of translational medicine2015

PIWIL2 promotes progression of non-small cell lung cancer by inducing CDK2 and Cyclin A expression.

Xiaohan Qu, Jinlu Liu, Xinwen Zhong, Xi Li, Qigang Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
7.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Xiaohan QuThe First Affiliated Hospital, China Medical University, NO. 155, Nanjing North Street, Heping District, Shenyang, 110001, Liaoning, China. han_seal@163.com.
Jinlu LiuThe Forth Affiliated Hospital, China Medical University, Shenyang, China. lnljl520@126.com.
Xinwen ZhongThe First Affiliated Hospital, China Medical University, NO. 155, Nanjing North Street, Heping District, Shenyang, 110001, Liaoning, China. xwzhong@mail.cmu.edu.cn.
Xi LiThe First Affiliated Hospital, China Medical University, NO. 155, Nanjing North Street, Heping District, Shenyang, 110001, Liaoning, China. 13889853625@163.com.
Qigang ZhangThe First Affiliated Hospital, China Medical University, NO. 155, Nanjing North Street, Heping District, Shenyang, 110001, Liaoning, China. 18040097645@163.com.
China Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPIWI proteins have important roles in tumorigenesis due to their interaction with piRNAs. Recent studies suggest that PIWI proteins affect prognosis of various cancers.

methodsIn the present study, PIWI genes expression was assayed in non-small cell lung cancer (NSCLC). To determine the effects of PIWIL2 on NSCLC cells, overexpression and interference assays were performed using the A549 and H460 cell lines. The tumor formation model was performed to demonstrate the effects of PIWIL2 on tumor formation in vivo.

resultsPIWIL2 was increased both at the RNA and protein level in malignant cancer tissues compared with adjacent normal tissue. Moreover, increased PIWIL2 gene expression was negatively correlated with prognosis in NSCLC patients. Overexpression and interference of PIWIL2 promoted and depressed cell proliferation, respectively. Meanwhile, PIWIL2 interference arrested cells at the G2/M stage. In addition, we found that CDK2 and Cyclin A expression were correlated with PIWIL2 expression. Moreover, transfection of PIWIL2 promoted tumor growth in nude mice.

conclusionOur findings shed light on the function of PIWIL2 in NSCLC and suggest potential prognostic and therapeutic value.

Indexed as

Gene Expression Regulation, NeoplasticAdultAnimalsArgonaute ProteinsCarcinoma, Non-Small-Cell LungCell Line, TumorCell ProliferationCyclin ACyclin-Dependent Kinase 2Disease ProgressionFemaleGene Expression ProfilingHumansLung NeoplasmsMaleMiceArgonaute ProteinsCDK2 protein, humanCyclin ACyclin-Dependent Kinase 2PIWIL2 protein, humanPiwil2 protein, mouseRNA

Identifiers

PMID26373553
PMCPMC4571108
OpenAlexW1908354105

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.