SynthesisPublic health nutrition2016
A dose-response meta-analysis reveals an association between vitamin B12 and colorectal cancer risk.
Synthesis in Public health nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Vitamin B6, vitamin B12 and methionine and risk of pancreatic cancer: a meta-analysis.Nutrition journal · 2020Pooled it
- Periodontal Disease and Tooth Loss Are Associated with Lung Cancer Risk.BioMed research international · 2020Pooled it
- Dietary intake of one-carbon nutrients and colorectal cancer risk according to TP53 status.JNCI cancer spectrum · 2026Article
- Association between Vitamin B12 Levels and Colon Cancer Survival: A Global Network Study.Cancer research communications · 2026Article
- B vitamins intake and cancer risk: a structured narrative review of evidence on riboflavin, pyridoxine, cobalamin and folate.Pathology oncology research : POR · 2026Review
- Mapping the Quantitative Dose-Response Relationships Between Nutrients and Health Outcomes to Inform Food Risk-Benefit Assessment.Foods (Basel, Switzerland) · 2025Review
- A probiotic Limosilactobacillus fermentum GR-3 mitigates colitis-associated tumorigenesis in mice via modulating gut microbiome.NPJ science of food · 2024Article
- Association between nutrient intake related to the one-carbon metabolism and colorectal cancer risk: a case-control study in the Basque Country.European journal of nutrition · 2023Observational
- Vitamin BFood & nutrition research · 2023Article
- Methyl Donors Reduce Cell Proliferation by Diminishing Erk-Signaling and NFkB Levels, While Increasing E-Cadherin Expression in Panc-1 Cell Line.International journal of molecular sciences · 2022Article
- Methyl-Donors Can Induce Apoptosis and Attenuate Both the Akt and the Erk1/2 Mediated Proliferation Pathways in Breast and Lung Cancer Cell Lines.International journal of molecular sciences · 2021Article
- Is There a Carcinogenic Risk Attached to Vitamin BMolecular nutrition & food research · 2021Review
- Association between Serum Vitamin B12 and Global DNA Methylation in Colorectal Cancer Patients.Nutrients · 2020Article
- Development of the anti-cancer food scoring system 2.0: Validation and nutritional analyses of quantitative anti-cancer food scoring model.Nutrition research and practice · 2020Article
- Intake of folate and other nutrients related to one-carbon metabolism and risk of cutaneous melanoma among US women and men.Cancer epidemiology · 2018Article
- Elevated Plasma Vitamin B12 Concentrations Are Independent Predictors of In-Hospital Mortality in Adult Patients at Nutritional Risk.Nutrients · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe current meta-analysis evaluated the association between vitamin B12 intake and blood vitamin B12 level and colorectal cancer (CRC) risk.
designThe PubMed and EMBASE databases were searched. A dose-response analysis was performed with generalized least squares regression, with the relative risk (RR) and 95 % CI as effect values.
settingThe meta-analysis included seventeen studies. SUBJECTS: A total of 10 601 patients.
resultsThe non-linear dose-response relationship between total vitamin B12 intake and CRC risk was insignificant (P=0·690), but the relationship between dietary vitamin B12 intake and CRC risk was significant (P<0·001). Every 4·5 μg/d increment in total and dietary vitamin B12 intake was inversely associated with CRC risk (total intake: RR=0·963; 95 % CI 0·928, 0·999; dietary intake: RR=0·914; 95 % CI 0·856, 0·977). The inverse association between vitamin B12 intake and CRC risk was also significant when vitamin B12 intake was over a dosage threshold, enhancing the non-linear relationship. The non-linear dose-response relationship between blood vitamin B12 level and CRC risk was insignificant (P=0·219). There was an insignificant association between every 150 pmol/l increment in blood vitamin B12 level and CRC risk (RR=1·023; 95 % CI 0·881, 1·187).
conclusionsOur meta-analysis indicates that evidence supports the use of vitamin B12 for cancer prevention, especially among populations with high-dose vitamin B12 intake, and that the association between CRC risk and total vitamin B12 intake is stronger than between CRC risk and dietary vitamin B12 intake only.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.