ArticleEnvironmental health perspectives2016
Exposure Classification and Temporal Variability in Urinary Bisphenol A Concentrations among Couples in Utah--The HOPE Study.
Article in Environmental health perspectives, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 38 citations in OpenAlex.
- Associations between pyrethroid insecticide concentrations and dyslipidemia: Findings from the Dongfeng-Tongji cohort.Science advances · 2026Article
- Bisphenol A and cancer: a critical review of the epidemiologic literature with an emphasis on exposure assessment.Environmental health : a global access science source · 2026Review
- Non-persistent endocrine disrupting chemical mixtures and uterine leiomyomata in the study of environment, lifestyle and fibroids (SELF).Chemosphere · 2024Article
- Prenatal exposure to environmental toxins and comprehensive dental findings in a population cohort of children.BMC oral health · 2024Article
- The State of Research and Weight of Evidence on the Epigenetic Effects of Bisphenol A.International journal of molecular sciences · 2023Article
- Urinary phenol concentrations and fecundability and early pregnancy loss.Human reproduction (Oxford, England) · 2023Article
- The associations of urinary DEHP metabolite levels, serum thyroid hormones, and thyroid-related genes among the adolescent students from China: a cross-sectional study.Environmental science and pollution research international · 2022Article
- Urinary concentrations of phenols, parabens, and triclocarban in relation to uterine leiomyomata incidence and growth.Fertility and sterility · 2021Article
- Male exposure to bisphenol A (BPA) and semen quality in the Home Observation of Periconceptional Exposures (HOPE) cohort.Reproductive toxicology (Elmsford, N.Y.) · 2019Article
- Association between peri-conceptional bisphenol A exposure in women and men and time to pregnancy-The HOPE study.Paediatric and perinatal epidemiology · 2019Article
- Classification and Temporal Variability in Urinary 8-oxodG and 8-oxoGuo: Analysis by UHPLC-MS/MS.Scientific reports · 2019Article
- Compliance with daily, home-based collection of urinary biospecimens in a prospective, preconception cohort.Environmental epidemiology (Philadelphia, Pa.) · 2019Article
- Biomonitoring and Nonpersistent Chemicals-Understanding and Addressing Variability and Exposure Misclassification.Current environmental health reports · 2019Review
- A risk of bias instrument for non-randomized studies of exposures: A users' guide to its application in the context of GRADE.Environment international · 2019Article
- A possible approach to improving the reproducibility of urinary concentrations of phthalate metabolites and phenols during pregnancy.Journal of exposure science & environmental epidemiology · 2018Article
- Distribution, variability, and predictors of urinary bisphenol A levels in 50 North Carolina adults over a six-week monitoring period.Environment international · 2018Article
- Challenges to studying the health effects of early life environmental chemical exposures on children's health.PLoS biology · 2017Article
- Early life bisphenol A exposure and neurobehavior at 8years of age: Identifying windows of heightened vulnerability.Environment international · 2017Article
- Exposure to multiple chemicals in a cohort of reproductive-aged Danish women.Environmental research · 2017Article
- Variability and exposure classification of urinary phenol and paraben metabolite concentrations in reproductive-aged women.Environmental research · 2016Article
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8 authors at 3 institutions in 1 country.
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Abstract
backgroundBisphenol A (BPA) is an endocrine disruptor and potential reproductive toxicant, but results of epidemiologic studies have been mixed and have been criticized for inadequate exposure assessment that often relies on a single measurement.
objectiveOur goal was to describe the distribution of BPA concentrations in serial urinary specimens, assess temporal variability, and provide estimates of exposure classification when randomly selected samples are used to predict average exposure.
methodsWe collected and analyzed 2,614 urine specimens from 83 Utah couples beginning in 2012. Female participants collected daily first-morning urine specimens during one to two menstrual cycles and male partners collected specimens during the woman's fertile window for each cycle. We measured urinary BPA concentrations and calculated geometric means (GM) for each cycle, characterized the distribution of observed values and temporal variability using intraclass correlation coefficients, and performed surrogate category analyses to determine how well repeat samples could classify exposure.
resultsThe GM urine BPA concentration was 2.78 ng/mL among males and 2.44 ng/mL among females. BPA had a high degree of variability among both males (ICC = 0.18; 95% CI: 0.11, 0.26) and females (ICC = 0.11; 95% CI: 0.08, 0.16). Based on our more stringent surrogate category analysis, to reach proportions ≥ 0.80 for sensitivity, specificity, and positive predictive value (PPV) among females, 6 and 10 repeat samples for the high and low tertiles, respectively, were required. For the medium tertile, specificity reached 0.87 with 10 repeat samples, but even with 11 samples, sensitivity and PPV did not exceed 0.36. Five repeat samples, among males, yielded sensitivity and PPV values ≥ 0.75 for the high and low tertiles, but, similar to females, classification for the medium tertile was less accurate.
conclusionRepeated urinary specimens are required to characterize typical BPA exposure. CITATION: Cox KJ, Porucznik CA, Anderson DJ, Brozek EM, Szczotka KM, Bailey NM, Wilkins DG, Stanford JB. 2016. Exposure classification and temporal variability in urinary bisphenol A concentrations among couples in Utah-the HOPE study. Environ Health Perspect 124:498-506; http://dx.doi.org/10.1289/ehp.1509752.
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