Evidence map›Paper›PMID 26372549›Full record

SynthesisPloS one2015

Effect of Carotene and Lycopene on the Risk of Prostate Cancer: A Systematic Review and Dose-Response Meta-Analysis of Observational Studies.

Yulan Wang, Ran Cui, Yuanyuan Xiao, Juemin Fang, Qing Xu

Erratum issuedOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 5 pooled it
8.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 5 syntheses or guidelines pooled it, 168 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yulan WangDepartment of Clinical Laboratory, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, No.301 Middle Yanchang Road, Zhabei District, Shanghai 200072, China.
Ran CuiDepartment of Oncology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, No.301 Middle Yanchang Road, Zhabei District, Shanghai 200072, China.
Yuanyuan XiaoDepartment of Oncology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, No.301 Middle Yanchang Road, Zhabei District, Shanghai 200072, China.
Juemin FangDepartment of Oncology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, No.301 Middle Yanchang Road, Zhabei District, Shanghai 200072, China.
Qing XuDepartment of Oncology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, No.301 Middle Yanchang Road, Zhabei District, Shanghai 200072, China.
Tongji University · CNShanghai Tenth People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMany epidemiologic studies have investigated the association between carotenoids intake and risk of Prostate cancer (PCa). However, results have been inconclusive.

methodsWe conducted a systematic review and dose-response meta-analysis of dietary intake or blood concentrations of carotenoids in relation to PCa risk. We summarized the data from 34 eligible studies (10 cohort, 11 nested case-control and 13 case-control studies) and estimated summary Risk Ratios (RRs) and 95% confidence intervals (CIs) using random-effects models.

resultsNeither dietary β-carotene intake nor its blood levels was associated with reduced PCa risk. Dietary α-carotene intake and lycopene consumption (both dietary intake and its blood levels) were all associated with reduced risk of PCa (RR for dietary α-carotene intake: 0.87, 95%CI: 0.76-0.99; RR for dietary lycopene intake: 0.86, 95%CI: 0.75-0.98; RR for blood lycopene levels: 0.81, 95%CI: 0.69-0.96). However, neither blood α-carotene levels nor blood lycopene levels could reduce the risk of advanced PCa. Dose-response analysis indicated that risk of PCa was reduced by 2% per 0.2mg/day (95%CI: 0.96-0.99) increment of dietary α-carotene intake or 3% per 1mg/day (95%CI: 0.94-0.99) increment of dietary lycopene intake.

conclusionsα-carotene and lycopene, but not β-carotene, were inversely associated with the risk of PCa. However, both α-carotene and lycopene could not lower the risk of advanced PCa.

Indexed as

Observational Studies as TopicCarotenoidsDose-Response Relationship, DrugHumansLycopeneMaleProstatic NeoplasmsRiskCarotenoidsLycopene

Identifiers

PMID26372549
PMCPMC4570783
OpenAlexW2213732062

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.