Evidence map›Paper›PMID 26372519›Full record

ArticlePediatric research2016

Serum concentrations of vascular endothelial growth factor in relation to retinopathy of prematurity.

Gunnel Hellgren, Chatarina Löfqvist, Anna-Lena Hård, Ingrid Hansen-Pupp, Magnus Gram, David Ley, Lois E Smith, Ann Hellström

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Pathophysiology of Retinopathy of Prematurity.Annual review of vision science · 2023
    Review
  10. Observational
  11. Article
  12. Article
  13. Article
  14. Impact of Platelet Count in Retinopathy of Prematurity.Turkish journal of ophthalmology · 2020
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Preterm Birth and Hypertension: Is There a Link?Current hypertension reports · 2016
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Gunnel HellgrenDepartment of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Chatarina LöfqvistDepartment of Ophthalmology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Anna-Lena HårdDepartment of Ophthalmology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Ingrid Hansen-PuppDepartment of Pediatrics, Institute of Clinical Sciences Lund, Lund University and Skane University Hospital, Lund, Sweden.
Magnus GramDepartment of Clinical Sciences, Institute of Clinical Sciences Lund, Lund University, Lund, Sweden.
David LeyDepartment of Pediatrics, Institute of Clinical Sciences Lund, Lund University and Skane University Hospital, Lund, Sweden.
Lois E SmithDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
Ann HellströmDepartment of Ophthalmology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
University of Gothenburg · SELund University · SEHarvard University · US

Funding

Dietary control of angiogenesis in retinopathy modelsR01EY017017 · NEI · BOSTON CHILDREN'S HOSPITAL · PI Zhongjie Fu, Lois Smith · 2006 to 2026
$11.8M
NEI NIH HHS R01 EY017017
6 · The paper itself

Abstract

backgroundThe role of vascular endothelial growth factor (VEGF) in the pathogenesis of retinopathy of prematurity (ROP) has been clearly established. However, little is known about temporal changes in circulating VEGF concentrations in the preterm infant. The objective was to determine the longitudinal serum concentrations of VEGF in relation to ROP.

methodsThis study included 52 infants born at <31 wk gestational age (non-ROP n = 33, nonproliferative ROP n = 10, treated for ROP n = 9). VEGF concentrations were analyzed in blood samples collected at birth, at 3 d postnatal age, and then weekly until at least a gestational age of 35 wk.

resultsVEGF concentrations at birth did not differ between groups, independent of later ROP status. In contrast, VEGF serum concentrations were significantly higher at first detection of ROP in infants who were later treated for ROP compared to infants without ROP. At the time of laser therapy, serum VEGF concentrations did not differ between groups.

conclusionCirculatory concentrations of VEGF, in infants who later developed severe ROP, were elevated at the time when ROP first was detected but not at the time when current treatment most often occurred. This supports the need for further studies of circulating VEGF in relation to the timing of ROP treatment.

Indexed as

ComorbidityFemaleFetal BloodGestational AgeHumansInfant, NewbornInfant, Newborn, DiseasesInfant, PrematureLaser TherapyMalePilot ProjectsProspective StudiesRetinopathy of PrematurityVascular Endothelial Growth Factor AVascular Endothelial Growth Factor AVEGFA protein, human

Identifiers

PMID26372519
PMCPMC5788569
OpenAlexW2125084520

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.