ArticlePediatric research2016
Influence of breastfeeding and postnatal nutrition on cardiovascular remodeling induced by fetal growth restriction.
Article in Pediatric research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Long-term benefits of exclusive human milk diet in small for gestational age neonates: a systematic review of the literature.Italian journal of pediatrics · 2024Pooled it
- Risk factors during first 1,000 days of life for carotid intima-media thickness in infants, children, and adolescents: A systematic review with meta-analyses.PLoS medicine · 2020Pooled it
- Trial
- Fetal cardiac remodeling in second trimester in pregnancies with pre-eclampsia and/or fetal growth restriction: deep-learning-based approach using population-wide data.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026Article
- The Impact of Fetal Growth Restriction on Myocardial Development from Fetal Life to Early Childhood: A Narrative Review.Children (Basel, Switzerland) · 2026Review
- Machine learning-enhanced prediction of fetal growth restriction using fetal cardiac remodeling parameters.BMC medicine · 2025Article
- Influence of Dietary Intake on Carotid Maximum Intima-Media Thickness in Children Conceived Through Assisted Reproductive Techniques.Nutrients · 2025Observational
- Early-Onset Fetal Growth Restriction Increases Left Ventricular Sphericity in Adolescents Born Very Preterm.Pediatric cardiology · 2024Article
- Cardiovascular Dysfunction in Intrauterine Growth Restriction.Current hypertension reports · 2022Review
- Acute and chronic cardiac adaptations in adults born preterm.Experimental physiology · 2022Review
- Exercise Capacity in Young Adults Born Small for Gestational Age.JAMA cardiology · 2021Article
- Breath of Life: Heart Disease Link to Developmental Hypoxia.Circulation · 2021Article
- Fetal Growth Restriction and Hypertension in the Offspring: Mechanistic Links and Therapeutic Directions.The Journal of pediatrics · 2020Review
- [Effect of breastfeeding on insulin sensitivity in infants with intrauterine growth retardation: a follow-up study].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2020Article
- Vascular changes in fetal growth restriction: clinical relevance and future therapeutics.Journal of perinatology : official journal of the California Perinatal Association · 2019Review
- Body Fatness and Cardiovascular Health in Newborn Infants.Journal of clinical medicine · 2018Article
- Neonatal Growth Restriction Slows Cardiomyocyte Development and Reduces Adult Heart Size.Anatomical record (Hoboken, N.J. : 2007) · 2018Article
- ω-3 Fatty Acids, Impaired Fetal Growth, and Cardiovascular Risk: Nutrition as Precision Medicine.Advances in nutrition (Bethesda, Md.) · 2018Review
- Vascular aging and cardiac maladaptation in growth-restricted preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2018Observational
- Clinician performed ultrasound in fetal growth restriction: fetal, neonatal and pediatric aspects.Journal of perinatology : official journal of the California Perinatal Association · 2017Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOur aim was to determine the influence of breastfeeding and postnatal nutrition on cardiovascular remodeling induced by fetal growth restriction (FGR).
methodsA cohort study including 81 children with birthweight <10th centile (FGR) and 121 with adequate fetal growth for gestational age (AGA) was conducted. Cardiovascular endpoints were left ventricular sphericity index (LVSI), carotid intima-media thickness (cIMT), and blood pressure (BP) at 4-5 y of age. The combined effect of FGR and postnatal variables-including breastfeeding, fat dietary intake, and BMI-on cardiovascular endpoints was assessed by linear and robust regressions.
resultsFGR was the strongest predictor of cardiovascular remodeling in childhood, leading to lower LVSI and increased cIMT and BP as compared with AGA. Breastfeeding >6 mo (coefficient: 0.0982) and healthy-fat dietary intake (coefficient: -0.0128) showed an independent beneficial effect on LVSI and cIMT, respectively. Overweight/obesity induced an additional increment of 1 SD on cIMT in FGR children (interaction coefficient: 0.0307) when compared with its effect in AGA. BMI increased systolic BP (coefficient: 0.7830) while weight catch-up increased diastolic BP (coefficient: 4.8929).
conclusionsPostnatal nutrition ameliorates cardiovascular remodeling induced by FGR. Breastfeeding and healthy-fat dietary intake improved while increased BMI worsened cardiovascular endpoints, which opens opportunities for targeted postnatal interventions from early life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.