ArticlePediatric research2016
Respiratory adaptation and surfactant composition of unanesthetized male and female lambs differ for up to 8 h after preterm birth.
Article in Pediatric research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- From Breath to Brain: NICU respiratory interventions and bedside brain signal entropy predict later autism risk.Developmental cognitive neuroscience · 2026Article
- High-frequency oscillatory ventilation during physiological-based cord clamping attenuates inflammation in preterm lambs.Archives of disease in childhood. Fetal and neonatal edition · 2026Article
- Impact of sex, race, and social determinants of health on neonatal outcomes.Frontiers in pediatrics · 2024Review
- Neonatal Pneumothorax Outcome in Preterm and Term Newborns.Medicina (Kaunas, Lithuania) · 2022Article
- Y It Matters-Sex Differences in Fetal Lung Development.Biomolecules · 2022Review
- Asphyxiated Female and Male Newborn Piglets Have Similar Outcomes With Different Cardiopulmonary Resuscitation Interventions.Frontiers in pediatrics · 2020Article
- Sex Differences Between Female and Male Newborn Piglets During Asphyxia, Resuscitation, and Recovery.Frontiers in pediatrics · 2019Article
- Moderate preterm birth affects right ventricular structure and function and pulmonary artery blood flow in adult sheep.The Journal of physiology · 2018Article
- Gender-related efficacy of pulmonary surfactant in infants with respiratory distress syndrome: A STROBE compliant study.Medicine · 2018Observational
- Surfactant phospholipid composition of gastric aspirate samples differs between male and female very preterm infants.Pediatric research · 2017Article
- Exacerbation of Ventilation-Induced Lung Injury and Inflammation in Preterm Lambs by High-Dose Nanoparticles.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMale preterm infants are more likely to experience respiratory distress syndrome than females. Our objectives were to determine if sex-related differences in physiological adaptation after preterm birth increase with time after birth and if the use of continuous positive airway pressure (CPAP) reduces these differences.
methodsUnanesthetized lambs (9F, 8M) were delivered at 0.90 of term. Blood gases, metabolites, and cardiovascular and respiratory parameters were monitored in spontaneously breathing lambs for 8 h. Supplemental oxygen was administered via a face mask at 4 cmH2O CPAP. At 8 h, lung compliance was determined, and bronchoalveolar lavage fluid (BALF) was analyzed for total protein and surfactant phospholipids. Surfactant protein (SP) gene expression and protein expression of SP-A and pro-SP-C were determined in lung tissue.
resultsFor 8 h after delivery, males had significantly lower arterial pH and higher Paco2, and a greater percentage of males were dependent on supplemental oxygen than females. Inspiratory effort was greater and lung compliance was lower in male lambs. Total protein concentration in BALF, SP gene expression, and SP-A protein levels were not different between sexes; pro-SP-C was 24% lower in males.
conclusionThe use of CPAP did not eliminate the male disadvantage, which continues for up to 8 h after preterm birth.
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