Evidence map›Paper›PMID 26372506›Full record

ArticleThe American journal of gastroenterology2015

Diagnostic Performance of Contrast-Enhanced MRI With Secretin-Stimulated MRCP for Non-Calcific Chronic Pancreatitis: A Comparison With Histopathology.

Guru Trikudanathan, Sidney P Walker, Satish Munigala, Ben Spilseth, Ahmad Malli, Yusheng Han, Melena Bellin, Srinath Chinnakotla, Ty Dunn, Timothy L Pruett and 8 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in The American journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Article
  4. T1 Mapping of the Abdomen, From theAJR. American journal of roentgenology · 2025
    Review
  5. Advances in MRI of Chronic Pancreatitis.Advances in clinical radiology · 2024
    Article
  6. Cross-sectional imaging of the pancreas in diabetes.Abdominal radiology (New York) · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Secretin-Enhanced MRCP: How and Why-AJR. American journal of roentgenology · 2021
    Review
  16. Groove pancreatitis has a spectrum of severity and can be managed conservatively.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2021
    Article
  17. Imaging of Fibrosis in Chronic Pancreatitis.Frontiers in physiology · 2021
    Review
  18. Review
  19. Advanced imaging techniques for chronic pancreatitis.Abdominal radiology (New York) · 2020
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 2 countries.

Guru TrikudanathanDivision of Gastroenterology, University of Minnesota, Minneapolis, Minnesota, USA.
Sidney P WalkerCenter for Diagnostic Imaging, Minneapolis, Minnesota, USA.
Satish MunigalaDivision of Gastroenterology, St Louis University School of Medicine, St. Louis, Missouri, USA.
Ben SpilsethDepartment of Radiology, University of Minnesota, Minneapolis, Minnesota, USA.
Ahmad MalliDepartment of Internal Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Yusheng HanDepartment of Pathology, University of Minnesota, Minneapolis, Minnesota, USA.
Melena BellinThe Schulze Diabetes Institute, University of Minnesota, Minneapolis, Minnesota, USA.
Srinath ChinnakotlaDepartment of Surgery, University of Minnesota, Minneapolis, Minnesota, USA.
Ty DunnDepartment of Surgery, University of Minnesota, Minneapolis, Minnesota, USA.
Timothy L PruettDepartment of Surgery, University of Minnesota, Minneapolis, Minnesota, USA.
Gregory J BeilmanDepartment of Surgery, University of Minnesota, Minneapolis, Minnesota, USA.
Jose Vega PeraltaDivision of Gastroenterology, University of Minnesota, Minneapolis, Minnesota, USA.
Mustafa A ArainDivision of Gastroenterology, University of Minnesota, Minneapolis, Minnesota, USA.
Stuart K AmateauDivision of Gastroenterology, University of Minnesota, Minneapolis, Minnesota, USA.
Sarah J SchwarzenbergDivision of Gastroenterology, University of Minnesota, Minneapolis, Minnesota, USA.
Shawn MalleryDivision of Gastroenterology, University of Minnesota, Minneapolis, Minnesota, USA.
Rajeev AttamDivision of Gastroenterology, University of Minnesota, Minneapolis, Minnesota, USA.
Martin L FreemanDivision of Gastroenterology, University of Minnesota, Minneapolis, Minnesota, USA.
University of Minnesota · USSpecim (Finland) · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesDiagnosis of non-calcific chronic pancreatitis (NCCP) in patients presenting with chronic abdominal pain is challenging and controversial. Contrast-enhanced magnetic resonance imaging (MRI) with secretin-stimulated MRCP (sMRCP) offers a safe and noninvasive modality to diagnose mild CP, but its findings have not been correlated with histopathology. We aimed to assess the correlation of a spectrum of MRI/sMRCP findings with surgical histopathology in a cohort of NCCP patients undergoing total pancreatectomy with islet autotransplantation (TPIAT).

methodsAdult patients undergoing TPIAT for NCCP between 2008 and 2013 were identified from our institution's surgery database and were included if they had MRI/sMRCP within a year before surgery. Histology was obtained from resected pancreas at the time of TPIAT by wedge biopsy of head, body, and tail, and was graded by a gastrointestinal pathologist who was blinded to the imaging features. A fibrosis score (FS) of 2 or more was considered as abnormal, with FS ≥6 as severe fibrosis. A multivariate regression analysis was performed for MRI features predicting fibrosis, after taking age, sex, smoking, alcohol, and body mass index (BMI) into consideration. A quantitative receiver operating characteristic (ROC) curve analysis was performed and Spearman rank correlation coefficient (r) was calculated.

resultsFifty-seven patients (females=49, males=8) with NCCP and MRI/sMRCP were identified. ROC curve analysis showed that two or more MRI/sMRCP features provided the best balance of sensitivity (65%), specificity (89%), and accuracy (68%) to differentiate abnormal (FS≥2) from normal pancreatic tissue. Two or more features provided the best cutoff (sensitivity 88%, specificity 78%) for predicting severe fibrosis (FS≥6). There was a significant correlation between the number of features and severity of fibrosis (r=0.6, P<0.0001). A linear regression after taking age, smoking, and BMI into consideration showed that main pancreatic duct irregularity, T1-weighted signal intensity ratio between pancreas and paraspinal muscle, and duodenal filling after secretin injection to be significant independent predictors of fibrosis.

conclusionsA strong correlation exists between MRI/sMRCP findings and histopathology of NCCP.

Indexed as

Magnetic Resonance ImagingAdultCholangiopancreatography, Magnetic ResonanceContrast MediaFemaleFibrosisGastrointestinal AgentsHumansIslets of Langerhans TransplantationMaleMiddle AgedPancreasPancreatectomyPancreatitis, ChronicPredictive Value of TestsRetrospective StudiesContrast MediaGastrointestinal AgentsSecretin

Identifiers

PMID26372506
OpenAlexW2232846520

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.