Evidence map›Paper›PMID 26372280›Full record

ArticleAIDS (London, England)2015

Factors associated with abnormal spirometry among HIV-infected individuals.

M Bradley Drummond, Laurence Huang, Philip T Diaz, Gregory D Kirk, Eric C Kleerup, Alison Morris, William Rom, Michael D Weiden, Enxu Zhao, Bruce Thompson and 1 more

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02154880 completednot on this map

Translation Evaluation of Aging, Inflammation and HIV in Lung Function

TypeobservationalSponsorUniversity of PittsburghRan2014 to 2020Enrolled323ConditionsHIV, COPD, Pulmonary Disease, AgingArmsPFT, lab work, 6MWT, questionnaires
NCT02238327 completednot on this map

The Study is a Multicenter, Prospective Observational Study of Pathogenesis of HIV Pulmonary Disease.

TypeobservationalSponsorUniversity of PittsburghRan2014 to 2020Enrolled232ConditionsChronic Obstructive Pulmonary Disease, HIV, EmphysemaArmsblood draw, questionnaires, Lung function testing, Six-Minute walk test, Quantitative CT scans
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. HIV-associated lung disease.Nature reviews. Disease primers · 2023
    Review
  6. Lung Function in Women With and Without Human Immunodeficiency Virus.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Article
  7. COPD in People with HIV: Epidemiology, Pathogenesis, Management, and Prevention Strategies.International journal of chronic obstructive pulmonary disease · 2023
    Review
  8. Article
  9. Article
  10. The influence of smoking and HIV infection on pulmonary function.Southern African journal of HIV medicine · 2022
    Article
  11. Observational
  12. Article
  13. Chronic obstructive pulmonary disease in HIV.Expert review of respiratory medicine · 2021
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Long-term pulmonary complications in perinatally HIV-infected youth.The Journal of allergy and clinical immunology · 2017
    Article
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 1 country.

M Bradley DrummondaDepartment of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland bDepartment of Medicine, School of Medicine, University of California San Francisco, San Francisco, California cDepartment of Medicine, Ohio State University, Columbus, Ohio dDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland eDepartment of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California fDepartments of Medicine and Immunology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania gDivision of Pulmonary & Critical Care Medicine, Departments of Medicine and Environmental Medicine, New York University School of Medicine, New York hClinical Trials and Survey Corporation, Owings Mills, Maryland iDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Laurence Huang
Philip T Diaz
Gregory D Kirk
Eric C Kleerup
Alison Morris
William Rom
Michael D Weiden
Enxu Zhao
Bruce Thompson
Kristina Crothers
Clinical Trials and Surveys Corporation · USJohns Hopkins University · USNew York University · USThe Ohio State University · USUniversity of California, Los Angeles · USUniversity of California, San Francisco · USUniversity of Pittsburgh · USUniversity of Washington · US

Funding

Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
NATURAL HISTORY OF AIDS IN HOMOSEXUAL MENU01AI035040 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DETELS, ROGER, MARTINEZ-MAZA, OTONIEL · 1993 to 2018
$75.2M
UNIVERSITY OF PITTSBURGH CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE: BPCAUL1RR024153 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2006 to 2011
$73.9M
University of Pittsburgh Multicenter AIDS Cohort Study (MACS)U01AI035041 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARTINSON, JEREMY JAMES, RINALDO, CHARLES R · 1993 to 2018
$71.4M
MULTICENTER AIDS COHORT STUDYU01AI035039 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WOLINSKY, STEVEN M · 1993 to 2018
$66.4M
Women's Interagency HIV Study (WIHS-V)U01AI035004 · NIAID · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI ANASTOS, KATHRYN M., SHARMA, ANJALI · 1993 to 2018
$65.7M
WOMEN'S INTERAGENCY HIV STUDY ORGANIZATION, MANAGEMENT AND COMMUNICATIONSU01AI034989 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, GREENBLATT, RUTH MARTHA · 1993 to 2018
$65.6M
Multicenter Aids Cohort Study- Part B (Baltimore Site)U01AI035042 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BROWN, TODD T, MARGOLICK, JOSEPH B. · 1993 to 2018
$61.5M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Women's Interagency HIV Study (WIHS) IIIU01AI031834 · NIAID · SUNY DOWNSTATE MEDICAL CENTER · PI GUSTAFSON, DEBORAH R., MINKOFF, HOWARD · 1998 to 2018
$53.5M
WOMEN'S INTERAGENCY HIV STUDY (WIHS) ORGANIZATION AND MANAGEMENTU01AI034994 · NIAID · GEORGETOWN UNIVERSITY · PI KASSAYE, SEBLE G · 1993 to 2018
$52.0M
Women's Interagency HIV Study (WIHS) IV, Chicago ConsortiumU01AI034993 · NIAID · HEKTOEN INSTITUTE FOR MEDICAL RESEARCH · PI COHEN, MARDGE H, FRENCH, AUDREY · 1994 to 2018
$51.0M
NCATS NIH HHS UL1 TR000004NCATS NIH HHS UL1 TR000005NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124NCATS NIH HHS UL1 TR000424NCRR NIH HHS 5-MO1-RR-00722NCRR NIH HHS M01 RR000722NCRR NIH HHS UL1 RR024153NHLBI NIH HHS K23 HL103192NHLBI NIH HHS K24 HL087713NHLBI NIH HHS R01 HL090313NHLBI NIH HHS R01HL090313NHLBI NIH HHS R01 HL090316NHLBI NIH HHS R01 HL090331NHLBI NIH HHS R01HL090331NHLBI NIH HHS R01 HL090335NHLBI NIH HHS R01 HL090339NHLBI NIH HHS R01 HL090342NHLBI NIH HHS R01 HL090483NHLBI NIH HHS R01HL090483NHLBI NIH HHS R01 HL126549NHLBI NIH HHS U01 HL121814NIAID NIH HHS K24 AI118591NIAID NIH HHS U01 AI031834NIAID NIH HHS U01 AI034989NIAID NIH HHS U01 AI034993NIAID NIH HHS U01 AI034994NIAID NIH HHS U01 AI035004NIAID NIH HHS U01 AI035039NIAID NIH HHS U01 AI035040NIAID NIH HHS U01 AI035041NIAID NIH HHS U01 AI035042NIAID NIH HHS U01 AI035043NIAID NIH HHS U01 AI037613NIAID NIH HHS U01 AI037984NIAID NIH HHS U01 AI042590NIAID NIH HHS U01 AI103408NIAID NIH HHS UM1 AI035043NIAID NIH HHS UO1-AI-31834NIAID NIH HHS UO1-AI-34989NIAID NIH HHS UO1-AI-34993NIAID NIH HHS UO1-AI-34994NIAID NIH HHS UO1-AI-35004NIAID NIH HHS UO1-AI-35039NIAID NIH HHS UO1-AI-35040NIAID NIH HHS UO1-AI-35041NIAID NIH HHS UO1-AI-35042NIAID NIH HHS UO1-AI-35043NIAID NIH HHS UO1-AI-37613NIAID NIH HHS UO1-AI-37984NIAID NIH HHS UO1-AI-42590NICHD NIH HHS U01 HD032632NICHD NIH HHS UO1-HD-32632NIDA NIH HHS R01 DA012568NIDA NIH HHS U01 DA036297
6 · The paper itself

Abstract

objectiveHIV-infected individuals are susceptible to development of chronic lung diseases, but little is known regarding the prevalence and risk factors associated with different spirometric abnormalities in this population. We sought to determine the prevalence, risk factors and performance characteristics of risk factors for spirometric abnormalities among HIV-infected individuals.

designCross-sectional cohort study.

methodsWe analyzed cross-sectional US data from the NHLBI-funded Lung-HIV consortium - a multicenter observational study of heterogeneous groups of HIV-infected participants in diverse geographic sites. Logistic regression analysis was performed to determine factors statistically significantly associated with spirometry patterns.

resultsA total of 908 HIV-infected individuals were included. The median age of the cohort was 50 years, 78% were men and 68% current smokers. An abnormal spirometry pattern was present in 37% of the cohort: 27% had obstructed and 10% had restricted spirometry patterns. Overall, age, smoking status and intensity, history of Pneumocystis infection, asthma diagnosis and presence of respiratory symptoms were independently associated with an abnormal spirometry pattern. Regardless of the presence of respiratory symptoms, five HIV-infected participants would need to be screened with spirometry to diagnose two individuals with any abnormal spirometry pattern.

conclusionsNearly 40% of a diverse US cohort of HIV-infected individuals had an abnormal spirometry pattern. Specific characteristics including age, smoking status, respiratory infection history and respiratory symptoms can identify those at risk for abnormal spirometry. The high prevalence of abnormal spirometry and the poor predictive capability of respiratory symptoms to identify abnormal spirometry should prompt clinicians to consider screening spirometry in HIV-infected populations.

Indexed as

AdultCohort StudiesCross-Sectional StudiesFemaleHIV InfectionsHumansLung DiseasesMaleMiddle AgedPrevalenceRisk FactorsSpirometryUnited States

Identifiers

PMID26372280
PMCPMC4571285
OpenAlexW2402159490

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.