Evidence map›Paper›PMID 26372179›Full record

ArticleEndocrinology2015

Differences in the Osteogenic Differentiation Capacity of Omental Adipose-Derived Stem Cells in Obese Patients With and Without Metabolic Syndrome.

Wilfredo Oliva-Olivera, Antonio Leiva Gea, Said Lhamyani, Leticia Coín-Aragüez, Juan Alcaide Torres, Maria Rosa Bernal-López, Pedro Pablo García-Luna, Salvador Morales Conde, Sonia Fernández-Veledo, Rajaa El Bekay and 1 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

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  11. Obesity and COVID-19: Molecular Mechanisms Linking Both Pandemics.International journal of molecular sciences · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wilfredo Oliva-OliveraDepartment of Clinical Endocrinology and Nutrition (W.O.-O., S.L., L.C.-A., J.A.T., R.E.B., F.J.T.), Institute of Biomedical Research of Malaga, Hospital Complex of Malaga (Virgen de la Victoria), University of Malaga, and Department of Orthopedic Surgery and Traumatology (A.L.G.), Virgen de la Victoria University Hospital and University of Malaga, and Department of Internal Medicine (M.R.B.-L.), Regional University Hospital of Malaga, Institute of Biomedical Research of Malaga, 29010 Malaga, Spain; Centro de Investigación Biomédica en Red of Obesity Physiopathology and Nutrition (W.O.-O., S.L., L..C.-A., J.A.T., M.R.B.-L., R.E.B., F.J.T.), and Centro de Investigación Biomédica en Red of Diabetes and Associated Metabolic Disorders (S.F.-V.), Institute of Health Salud Carlos III, 28029 Madrid, Spain; Department of Endocrinology and Nutrition (P.P.G.L.) and Unit of Innovation in Minimally Invasive Surgery (S.M.C.), Department of Surgery, Virgen del Rocío University Hospital, 41013 Seville, Spain; and University Hospital of Tarragona Joan XXIII Institut d'Investigació (S.F.-V.), Sanitaria Pere Virgili, Universitat Rovirai Virgili, 43003 Tarragona, Spain.
Antonio Leiva GeaDepartment of Clinical Endocrinology and Nutrition (W.O.-O., S.L., L.C.-A., J.A.T., R.E.B., F.J.T.), Institute of Biomedical Research of Malaga, Hospital Complex of Malaga (Virgen de la Victoria), University of Malaga, and Department of Orthopedic Surgery and Traumatology (A.L.G.), Virgen de la Victoria University Hospital and University of Malaga, and Department of Internal Medicine (M.R.B.-L.), Regional University Hospital of Malaga, Institute of Biomedical Research of Malaga, 29010 Malaga, Spain; Centro de Investigación Biomédica en Red of Obesity Physiopathology and Nutrition (W.O.-O., S.L., L..C.-A., J.A.T., M.R.B.-L., R.E.B., F.J.T.), and Centro de Investigación Biomédica en Red of Diabetes and Associated Metabolic Disorders (S.F.-V.), Institute of Health Salud Carlos III, 28029 Madrid, Spain; Department of Endocrinology and Nutrition (P.P.G.L.) and Unit of Innovation in Minimally Invasive Surgery (S.M.C.), Department of Surgery, Virgen del Rocío University Hospital, 41013 Seville, Spain; and University Hospital of Tarragona Joan XXIII Institut d'Investigació (S.F.-V.), Sanitaria Pere Virgili, Universitat Rovirai Virgili, 43003 Tarragona, Spain.
Said LhamyaniDepartment of Clinical Endocrinology and Nutrition (W.O.-O., S.L., L.C.-A., J.A.T., R.E.B., F.J.T.), Institute of Biomedical Research of Malaga, Hospital Complex of Malaga (Virgen de la Victoria), University of Malaga, and Department of Orthopedic Surgery and Traumatology (A.L.G.), Virgen de la Victoria University Hospital and University of Malaga, and Department of Internal Medicine (M.R.B.-L.), Regional University Hospital of Malaga, Institute of Biomedical Research of Malaga, 29010 Malaga, Spain; Centro de Investigación Biomédica en Red of Obesity Physiopathology and Nutrition (W.O.-O., S.L., L..C.-A., J.A.T., M.R.B.-L., R.E.B., F.J.T.), and Centro de Investigación Biomédica en Red of Diabetes and Associated Metabolic Disorders (S.F.-V.), Institute of Health Salud Carlos III, 28029 Madrid, Spain; Department of Endocrinology and Nutrition (P.P.G.L.) and Unit of Innovation in Minimally Invasive Surgery (S.M.C.), Department of Surgery, Virgen del Rocío University Hospital, 41013 Seville, Spain; and University Hospital of Tarragona Joan XXIII Institut d'Investigació (S.F.-V.), Sanitaria Pere Virgili, Universitat Rovirai Virgili, 43003 Tarragona, Spain.
Leticia Coín-AragüezDepartment of Clinical Endocrinology and Nutrition (W.O.-O., S.L., L.C.-A., J.A.T., R.E.B., F.J.T.), Institute of Biomedical Research of Malaga, Hospital Complex of Malaga (Virgen de la Victoria), University of Malaga, and Department of Orthopedic Surgery and Traumatology (A.L.G.), Virgen de la Victoria University Hospital and University of Malaga, and Department of Internal Medicine (M.R.B.-L.), Regional University Hospital of Malaga, Institute of Biomedical Research of Malaga, 29010 Malaga, Spain; Centro de Investigación Biomédica en Red of Obesity Physiopathology and Nutrition (W.O.-O., S.L., L..C.-A., J.A.T., M.R.B.-L., R.E.B., F.J.T.), and Centro de Investigación Biomédica en Red of Diabetes and Associated Metabolic Disorders (S.F.-V.), Institute of Health Salud Carlos III, 28029 Madrid, Spain; Department of Endocrinology and Nutrition (P.P.G.L.) and Unit of Innovation in Minimally Invasive Surgery (S.M.C.), Department of Surgery, Virgen del Rocío University Hospital, 41013 Seville, Spain; and University Hospital of Tarragona Joan XXIII Institut d'Investigació (S.F.-V.), Sanitaria Pere Virgili, Universitat Rovirai Virgili, 43003 Tarragona, Spain.
Juan Alcaide TorresDepartment of Clinical Endocrinology and Nutrition (W.O.-O., S.L., L.C.-A., J.A.T., R.E.B., F.J.T.), Institute of Biomedical Research of Malaga, Hospital Complex of Malaga (Virgen de la Victoria), University of Malaga, and Department of Orthopedic Surgery and Traumatology (A.L.G.), Virgen de la Victoria University Hospital and University of Malaga, and Department of Internal Medicine (M.R.B.-L.), Regional University Hospital of Malaga, Institute of Biomedical Research of Malaga, 29010 Malaga, Spain; Centro de Investigación Biomédica en Red of Obesity Physiopathology and Nutrition (W.O.-O., S.L., L..C.-A., J.A.T., M.R.B.-L., R.E.B., F.J.T.), and Centro de Investigación Biomédica en Red of Diabetes and Associated Metabolic Disorders (S.F.-V.), Institute of Health Salud Carlos III, 28029 Madrid, Spain; Department of Endocrinology and Nutrition (P.P.G.L.) and Unit of Innovation in Minimally Invasive Surgery (S.M.C.), Department of Surgery, Virgen del Rocío University Hospital, 41013 Seville, Spain; and University Hospital of Tarragona Joan XXIII Institut d'Investigació (S.F.-V.), Sanitaria Pere Virgili, Universitat Rovirai Virgili, 43003 Tarragona, Spain.
Maria Rosa Bernal-LópezDepartment of Clinical Endocrinology and Nutrition (W.O.-O., S.L., L.C.-A., J.A.T., R.E.B., F.J.T.), Institute of Biomedical Research of Malaga, Hospital Complex of Malaga (Virgen de la Victoria), University of Malaga, and Department of Orthopedic Surgery and Traumatology (A.L.G.), Virgen de la Victoria University Hospital and University of Malaga, and Department of Internal Medicine (M.R.B.-L.), Regional University Hospital of Malaga, Institute of Biomedical Research of Malaga, 29010 Malaga, Spain; Centro de Investigación Biomédica en Red of Obesity Physiopathology and Nutrition (W.O.-O., S.L., L..C.-A., J.A.T., M.R.B.-L., R.E.B., F.J.T.), and Centro de Investigación Biomédica en Red of Diabetes and Associated Metabolic Disorders (S.F.-V.), Institute of Health Salud Carlos III, 28029 Madrid, Spain; Department of Endocrinology and Nutrition (P.P.G.L.) and Unit of Innovation in Minimally Invasive Surgery (S.M.C.), Department of Surgery, Virgen del Rocío University Hospital, 41013 Seville, Spain; and University Hospital of Tarragona Joan XXIII Institut d'Investigació (S.F.-V.), Sanitaria Pere Virgili, Universitat Rovirai Virgili, 43003 Tarragona, Spain.
Pedro Pablo García-LunaDepartment of Clinical Endocrinology and Nutrition (W.O.-O., S.L., L.C.-A., J.A.T., R.E.B., F.J.T.), Institute of Biomedical Research of Malaga, Hospital Complex of Malaga (Virgen de la Victoria), University of Malaga, and Department of Orthopedic Surgery and Traumatology (A.L.G.), Virgen de la Victoria University Hospital and University of Malaga, and Department of Internal Medicine (M.R.B.-L.), Regional University Hospital of Malaga, Institute of Biomedical Research of Malaga, 29010 Malaga, Spain; Centro de Investigación Biomédica en Red of Obesity Physiopathology and Nutrition (W.O.-O., S.L., L..C.-A., J.A.T., M.R.B.-L., R.E.B., F.J.T.), and Centro de Investigación Biomédica en Red of Diabetes and Associated Metabolic Disorders (S.F.-V.), Institute of Health Salud Carlos III, 28029 Madrid, Spain; Department of Endocrinology and Nutrition (P.P.G.L.) and Unit of Innovation in Minimally Invasive Surgery (S.M.C.), Department of Surgery, Virgen del Rocío University Hospital, 41013 Seville, Spain; and University Hospital of Tarragona Joan XXIII Institut d'Investigació (S.F.-V.), Sanitaria Pere Virgili, Universitat Rovirai Virgili, 43003 Tarragona, Spain.
Salvador Morales CondeDepartment of Clinical Endocrinology and Nutrition (W.O.-O., S.L., L.C.-A., J.A.T., R.E.B., F.J.T.), Institute of Biomedical Research of Malaga, Hospital Complex of Malaga (Virgen de la Victoria), University of Malaga, and Department of Orthopedic Surgery and Traumatology (A.L.G.), Virgen de la Victoria University Hospital and University of Malaga, and Department of Internal Medicine (M.R.B.-L.), Regional University Hospital of Malaga, Institute of Biomedical Research of Malaga, 29010 Malaga, Spain; Centro de Investigación Biomédica en Red of Obesity Physiopathology and Nutrition (W.O.-O., S.L., L..C.-A., J.A.T., M.R.B.-L., R.E.B., F.J.T.), and Centro de Investigación Biomédica en Red of Diabetes and Associated Metabolic Disorders (S.F.-V.), Institute of Health Salud Carlos III, 28029 Madrid, Spain; Department of Endocrinology and Nutrition (P.P.G.L.) and Unit of Innovation in Minimally Invasive Surgery (S.M.C.), Department of Surgery, Virgen del Rocío University Hospital, 41013 Seville, Spain; and University Hospital of Tarragona Joan XXIII Institut d'Investigació (S.F.-V.), Sanitaria Pere Virgili, Universitat Rovirai Virgili, 43003 Tarragona, Spain.
Sonia Fernández-VeledoDepartment of Clinical Endocrinology and Nutrition (W.O.-O., S.L., L.C.-A., J.A.T., R.E.B., F.J.T.), Institute of Biomedical Research of Malaga, Hospital Complex of Malaga (Virgen de la Victoria), University of Malaga, and Department of Orthopedic Surgery and Traumatology (A.L.G.), Virgen de la Victoria University Hospital and University of Malaga, and Department of Internal Medicine (M.R.B.-L.), Regional University Hospital of Malaga, Institute of Biomedical Research of Malaga, 29010 Malaga, Spain; Centro de Investigación Biomédica en Red of Obesity Physiopathology and Nutrition (W.O.-O., S.L., L..C.-A., J.A.T., M.R.B.-L., R.E.B., F.J.T.), and Centro de Investigación Biomédica en Red of Diabetes and Associated Metabolic Disorders (S.F.-V.), Institute of Health Salud Carlos III, 28029 Madrid, Spain; Department of Endocrinology and Nutrition (P.P.G.L.) and Unit of Innovation in Minimally Invasive Surgery (S.M.C.), Department of Surgery, Virgen del Rocío University Hospital, 41013 Seville, Spain; and University Hospital of Tarragona Joan XXIII Institut d'Investigació (S.F.-V.), Sanitaria Pere Virgili, Universitat Rovirai Virgili, 43003 Tarragona, Spain.
Rajaa El BekayDepartment of Clinical Endocrinology and Nutrition (W.O.-O., S.L., L.C.-A., J.A.T., R.E.B., F.J.T.), Institute of Biomedical Research of Malaga, Hospital Complex of Malaga (Virgen de la Victoria), University of Malaga, and Department of Orthopedic Surgery and Traumatology (A.L.G.), Virgen de la Victoria University Hospital and University of Malaga, and Department of Internal Medicine (M.R.B.-L.), Regional University Hospital of Malaga, Institute of Biomedical Research of Malaga, 29010 Malaga, Spain; Centro de Investigación Biomédica en Red of Obesity Physiopathology and Nutrition (W.O.-O., S.L., L..C.-A., J.A.T., M.R.B.-L., R.E.B., F.J.T.), and Centro de Investigación Biomédica en Red of Diabetes and Associated Metabolic Disorders (S.F.-V.), Institute of Health Salud Carlos III, 28029 Madrid, Spain; Department of Endocrinology and Nutrition (P.P.G.L.) and Unit of Innovation in Minimally Invasive Surgery (S.M.C.), Department of Surgery, Virgen del Rocío University Hospital, 41013 Seville, Spain; and University Hospital of Tarragona Joan XXIII Institut d'Investigació (S.F.-V.), Sanitaria Pere Virgili, Universitat Rovirai Virgili, 43003 Tarragona, Spain.
Francisco José TinahonesDepartment of Clinical Endocrinology and Nutrition (W.O.-O., S.L., L.C.-A., J.A.T., R.E.B., F.J.T.), Institute of Biomedical Research of Malaga, Hospital Complex of Malaga (Virgen de la Victoria), University of Malaga, and Department of Orthopedic Surgery and Traumatology (A.L.G.), Virgen de la Victoria University Hospital and University of Malaga, and Department of Internal Medicine (M.R.B.-L.), Regional University Hospital of Malaga, Institute of Biomedical Research of Malaga, 29010 Malaga, Spain; Centro de Investigación Biomédica en Red of Obesity Physiopathology and Nutrition (W.O.-O., S.L., L..C.-A., J.A.T., M.R.B.-L., R.E.B., F.J.T.), and Centro de Investigación Biomédica en Red of Diabetes and Associated Metabolic Disorders (S.F.-V.), Institute of Health Salud Carlos III, 28029 Madrid, Spain; Department of Endocrinology and Nutrition (P.P.G.L.) and Unit of Innovation in Minimally Invasive Surgery (S.M.C.), Department of Surgery, Virgen del Rocío University Hospital, 41013 Seville, Spain; and University Hospital of Tarragona Joan XXIII Institut d'Investigació (S.F.-V.), Sanitaria Pere Virgili, Universitat Rovirai Virgili, 43003 Tarragona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple studies have suggested that the reduced differentiation capacity of multipotent adipose tissue-derived mesenchymal stem cells (ASCs) in obese subjects could compromise their use in cell therapy. Our aim was to assess the osteogenic potential of omental ASCs and to examine the status of the isolated CD34(negative)-enriched fraction of omental-derived ASCs from subjects with different metabolic profiles. Omental ASCs from normal-weight subjects and subjects with or without metabolic syndrome were isolated, and the osteogenic potential of omental ASCs was evaluated. Additionally, osteogenic and clonogenic potential, proliferation rate, mRNA expression levels of proteins involved in redox balance, and fibrotic proteins were examined in the CD34(negative)-enriched fraction of omental-derived ASCs. Both the omental ASCs and the CD34(negative)-enriched fraction of omental ASCs from subjects without metabolic syndrome have a greater osteogenic potential than those from subjects with metabolic syndrome. The alkaline phosphatase and osteonectin mRNA were negatively correlated with nicotinamide adenine dinucleotide phosphate oxidase-2 mRNA and the mRNA expression levels of the fibrotic proteins correlated positively with nicotinamide adenine dinucleotide phosphate oxidase-5 mRNA and the homeostasis model assessment. Although the population doubling time was significantly higher in subjects with a body mass index of 25 kg/m(2) or greater, only the CD34(negative)-enriched omental ASC fraction in the subjects with metabolic syndrome had a higher population doubling time than the normal-weight subjects. The osteogenic, clonogenic, fibrotic potential, and proliferation rate observed in vitro suggest that omental ASCs from subjects without metabolic syndrome are more suitable for therapeutic osteogenic applications than those from subjects with metabolic syndrome.

Indexed as

Cell DifferentiationAdipose TissueAdultAlkaline PhosphataseAntigens, CD34Body Mass IndexCase-Control StudiesCells, CulturedFemaleFibrosisHumansMaleMembrane GlycoproteinsMembrane ProteinsMesenchymal Stem CellsMetabolic SyndromeAlkaline PhosphataseAntigens, CD34CYBB protein, humanMembrane GlycoproteinsMembrane ProteinsNADPH Oxidase 2NADPH Oxidase 5NADPH OxidasesNOX5 protein, humanOsteonectinRNA, Messenger

Identifiers

PMID26372179
PMCPMC4655209

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