ArticlePloS one2015
Changes in Serum Free Amino Acids and Muscle Fatigue Experienced during a Half-Ironman Triathlon.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05672758 (The Effect of Long-lasting Adaptation to Intensive Speed-power and Endurance Training on Plasma Free Amino Acids Concentration at Rest, During Graded Exercise and Post-exercise Recovery), which is not on this map. Cited by 24 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Long-lasting Adaptation to Intensive Speed-power and Endurance Training on Plasma Free Amino Acids Concentration at Rest, During Graded Exercise and Post-exercise Recovery
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Performance, physiology, and determinants of success in IRONMAN® 70.3: A systematic review.PloS one · 2026Pooled it
- Effect of prebiotics, probiotics, and synbiotics on gastrointestinal outcomes in healthy adults and active adults at rest and in response to exercise-A systematic literature review.Frontiers in nutrition · 2022Pooled it
- Trial
- Trial
- Kynurenine Pathway Modulation by Exercise in Multiple Sclerosis: Implications for Neuroprotection and Inflammation.Cellular and molecular neurobiology · 2025Review
- Review
- Article
- An investigation into how the timing of nutritional supplements affects the recovery from post-exercise fatigue: a systematic review and meta-analysis.Frontiers in nutrition · 2025Review
- Exercise-Induced Central Fatigue: Biomarkers and Non-Medicinal Interventions.Aging and disease · 2024Review
- Effect of 2 weeks rest-pause on oxidative stress and inflammation in female basketball players.Scientific reports · 2024Article
- Changes in Plasma Free Amino Acid Profile in Endurance Athletes over a 9-Month Training Cycle.Metabolites · 2024Article
- Cycling is the most important predictive split discipline in professional Ironman® 70.3 triathletes.Frontiers in sports and active living · 2024Article
- Association of Genetically Predicted BCAA Levels with Muscle Fiber Size in Athletes Consuming Protein.Genes · 2022Article
- Tryptophan recovery index as a new biomarker for fitness.EXCLI journal · 2022Article
- Effects of military training on plasma amino acid concentrations and their associations with overreaching.Experimental biology and medicine (Maywood, N.J.) · 2020Article
- Effects of Oral Branched-Chain Amino Acids (BCAAs) Intake on Muscular and Central Fatigue During an Incremental Exercise.Journal of human kinetics · 2020Article
- Quantification of Plasma Kynurenine Metabolites Following One Bout of Sprint Interval Exercise.International journal of tryptophan research : IJTR · 2020Article
- Changes of cardiac biomarkers after ultradistance and standard-distance triathlon.Journal of exercise rehabilitation · 2019Article
- BCKDK of BCAA Catabolism Cross-talking With the MAPK Pathway Promotes Tumorigenesis of Colorectal Cancer.EBioMedicine · 2017Article
- ACTN3 X-allele carriers had greater levels of muscle damage during a half-ironman.European journal of applied physiology · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate the relationship between changes in serum free amino acids, muscle fatigue and exercise-induced muscle damage during a half-ironman triathlon. Twenty-six experienced triathletes (age = 37.0 ± 6.8 yr; experience = 7.4 ± 3.0 yr) competed in a real half-ironman triathlon in which sector times and total race time were measured by means of chip timing. Before and after the race, a countermovement jump and a maximal isometric force test were performed, and blood samples were withdrawn to measure serum free amino acids concentrations, and serum creatine kinase levels as a blood marker of muscle damage. Total race time was 320 ± 37 min and jump height (-16.3 ± 15.2%, P < 0.001) and isometric force (-14.9 ± 9.8%; P = 0.007) were significantly reduced after the race in all participants. After the race, the serum concentration of creatine kinase increased by 368 ± 187% (P < 0.001). In contrast, the serum concentrations of essential (-27.1 ± 13.0%; P < 0.001) and non-essential amino acids (-24.4 ± 13.1%; P < 0.001) were significantly reduced after the race. The tryptophan/BCAA ratio increased by 42.7 ± 12.7% after the race. Pre-to-post changes in serum free amino acids did not correlate with muscle performance variables or post-race creatine kinase concentration. In summary, during a half-ironman triathlon, serum amino acids concentrations were reduced by > 20%. However, neither the changes in serum free amino acids nor the tryptophan/BCAA ratio were related muscle fatigue or muscle damage during the race.
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