Evidence map›Paper›PMID 26372038›Full record

ReviewCurrent opinion in urology2015

Immunotherapies for bladder cancer: a new hope.

Farhad Fakhrejahani, Yusuke Tomita, Agnes Maj-Hes, Jane B Trepel, Maria De Santis, Andrea B Apolo

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in urology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Immunotherapy in genitourinary malignancies.Current opinion in urology · 2016
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 4 countries.

Farhad FakhrejahaniaGenitourinary Malignancies Branch bDevelopmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA cDepartment of Urology, Medical University of Vienna, Vienna, Austria dCancer Research Unit, Warwick University Medical School, Coventry, UK.
Yusuke Tomita
Agnes Maj-Hes
Jane B Trepel
Maria De Santis
Andrea B Apolo
National Cancer Institute · USNational Institutes of Health · USMedical University of Vienna · ATUniversity of Warwick · GB

Funding

Bladder Cancer ProgramZIABC011351 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI APOLO, ANDREA · 2010 to 2025
$9.4M
Intramural NIH HHS ZIA BC011351
6 · The paper itself

Abstract

purpose of reviewWe review recent data on immunotherapies for bladder cancer and discuss strategies to maximize the antitumor effect of immunotherapy in solid tumors. RECENT

findingsAnti-programmed death ligand 1 has shown promise in advanced bladder cancer. Clinical trials of immune checkpoint inhibitors as monotherapy or in combination are underway. Here we review strategies for enhancing antitumor immunity using immunomodulating agents or combination treatments that may increase tumor response. SUMMARY: Combining immune checkpoint inhibitors with other treatment modalities may lead to the development of new treatment strategies in advanced bladder cancer; however, identifying predictive biomarkers is essential for appropriate patient selection.

Indexed as

AnimalsAntineoplastic AgentsChemoradiotherapyHumansImmunotherapyImmunotherapy, AdoptiveMolecular Targeted TherapyProgrammed Cell Death 1 ReceptorSignal TransductionTreatment OutcomeUrinary Bladder NeoplasmsAntineoplastic AgentsPDCD1 protein, humanProgrammed Cell Death 1 Receptor

Identifiers

PMID26372038
PMCPMC6777558
OpenAlexW1434691059

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.