ArticleThe Journal of allergy and clinical immunology2015
Chronic cat allergen exposure induces a TH2 cell-dependent IgG4 response related to low sensitization.
Article in The Journal of allergy and clinical immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 48 citations in OpenAlex.
- Allergy to Cats: Current Perspectives and Therapeutic Options.Clinical and translational allergy · 2026Review
- Review
- Single cell profiling of circulating autoreactive CD4 T cells from patients with autoimmune liver diseases suggests tissue imprinting.Nature communications · 2025Article
- Biomarkers in allergen immunotherapy: Focus on eosinophilic inflammation.Asia Pacific allergy · 2024Review
- Divergent Trends in the Prevalence of Children's Asthma, Rhinitis and Atopic Dermatitis and Environmental Influences in the Urban Setting of Zagreb, Croatia.Children (Basel, Switzerland) · 2022Article
- The clinical significance of allergen-specific IgG4 in allergic diseases.Frontiers in immunology · 2022Review
- Clinical and immunological evaluation of cat-allergic asthmatics living with or without a cat.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021Article
- An Overview of the Relevance of IgG4 Antibodies in Allergic Disease with a Focus on Food Allergens.Children (Basel, Switzerland) · 2021Review
- FB5P-seq: FACS-Based 5-Prime End Single-Cell RNA-seq for Integrative Analysis of Transcriptome and Antigen Receptor Repertoire in B and T Cells.Frontiers in immunology · 2020Article
- Antigen-specific regulatory T-cell responses against aeroantigens and their role in allergy.Mucosal immunology · 2018Review
- The future outlook on allergen immunotherapy in children: 2018 and beyond.Italian journal of pediatrics · 2018Review
- Synchronous immune alterations mirror clinical response during allergen immunotherapy.The Journal of allergy and clinical immunology · 2018Article
- Immunotherapy for pet allergies.Human vaccines & immunotherapeutics · 2018Review
- Cross-sectional study on sensitization to mite and cockroach allergen components in allergy patients in the Central European region.Clinical and translational allergy · 2018Article
- Heterogeneity of Ara h Component-Specific CD4 T Cell Responses in Peanut-Allergic Subjects.Frontiers in immunology · 2018Article
- Pathogenic CD4The Journal of allergy and clinical immunology · 2017Review
- Long-term exposure to Myozyme results in a decrease of anti-drug antibodies in late-onset Pompe disease patients.Scientific reports · 2016Article
- House Dust Mite Allergens: New Discoveries and Relevance to the Allergic Patient.Current allergy and asthma reports · 2016Review
- Effect of allergen-specific immunotherapy on CD4+ T cells.Current opinion in allergy and clinical immunology · 2015Review
Corrections and comments
- Commented on by
- Commented on byReply.2016
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundIn human subjects, allergen tolerance has been observed after high-dose allergen exposure or after completed allergen immunotherapy, which is related to the accumulation of anti-inflammatory IgG4. However, the specific T-cell response that leads to IgG4 induction during chronic allergen exposure remains poorly understood.
objectiveWe sought to evaluate the relationship between cat allergen-specific T-cell frequency, cat allergen-specific IgE and IgG4 titers, and clinical status in adults with cat allergy with and without cat ownership and the cellular mechanism by which IgG4 is produced.
methodsFel d 1-, Fel d 4-, Fel d 7-, and Fel d 8-specific T-cell responses were characterized by CD154 expression after antigen stimulation.
resultsIn allergic subjects without cat ownership, the frequency of cat allergen (Fel d 1 and Fel d 4)-specific TH2 (sTH2) cells correlates with higher IgE levels and is linked to asthma. Paradoxically, we observed that subjects with cat allergy and chronic cat exposure maintain a high frequency of sTH2 cells, which correlates with higher IgG4 levels and low sensitization. B cells from allergic, but not nonallergic subjects, are able to produce IgG4 after cognate interactions with sTH2 clones and Fel d 1 peptide or the Fel d 1 recombinant protein.
conclusionThese experiments suggest that (1) allergen-experienced B cells with the capacity to produce IgG4 are present in allergic subjects and (2) cat allergen exposure induces an IgG4 response in a TH2 cell-dependent manner. Thus IgG4 accumulation could be mediated by chronic activation of the TH2 response, which in turn drives desensitization.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.