ArticlePain2016
Test-retest reliability of pain-related functional brain connectivity compared with pain self-report.
Article in Pain, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Neuroimaging Assessment of Pain.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022Review
- Comparison of test-retest reliability of BOLD and pCASL fMRI in a two-center study.BMC medical imaging · 2022Article
- Effect sizes and test-retest reliability of the fMRI-based neurologic pain signature.NeuroImage · 2022Article
- Noxious pressure stimulation demonstrates robust, reliable estimates of brain activity and self-reported pain.NeuroImage · 2020Article
- Re-test reliability and internal consistency of EEG alpha-band oscillations in older adults with chronic knee pain.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2020Article
- Acute Alcohol Intake Produces Widespread Decreases in Cortical Resting Signal Variability in Healthy Social Drinkers.Alcoholism, clinical and experimental research · 2020Article
- Intrinsic Connectivity Networks in the Self- and Other-Referential Processing.Frontiers in human neuroscience · 2020Article
- Response to "Treating patients rather than their functional neuroimages" (Br J Anaesth 2018; 121: 969-71).British journal of anaesthesia · 2019Article
- Exploring the potential role of mesocorticolimbic circuitry in motivation for and adherence to chronic pain self-management interventions.Neuroscience and biobehavioral reviews · 2019Review
- Worsen depression after viscosupplementation treatment for geriatric people with knee osteoarthritis?International journal of clinical and health psychology : IJCHP · 2019Article
- Treating patients rather than their functional neuroimages. Comment on Br J Anaesth 2018; 120: 299-307.British journal of anaesthesia · 2018Article
- Biomarkers for Musculoskeletal Pain Conditions: Use of Brain Imaging and Machine Learning.Current rheumatology reports · 2017Review
- The Effect of Base Rate on the Predictive Value of Brain Biomarkers.The journal of pain · 2016Article
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4 authors.
Funding
Abstract
Test-retest reliability, or reproducibility of results over time, is poorly established for functional brain connectivity (fcMRI) during painful stimulation. As reliability informs the validity of research findings, it is imperative to examine, especially given recent emphasis on using functional neuroimaging as a tool for biomarker development. Although proposed pain neural signatures have been derived using complex, multivariate algorithms, even the reliability of less complex fcMRI findings has yet to be reported. This study examined the test-retest reliability for fcMRI of pain-related brain regions, and self-reported pain (through visual analogue scales [VASs]). Thirty-two healthy individuals completed 3 consecutive fMRI runs of a thermal pain task. Functional connectivity analyses were completed on pain-related brain regions. Intraclass correlations were conducted on fcMRI values and VAS scores across the fMRI runs. Intraclass correlations coefficients for fcMRI values varied widely (range = -.174-.766), with fcMRI between right nucleus accumbens and medial prefrontal cortex showing the highest reliability (range = .649-.766). Intraclass correlations coefficients for VAS scores ranged from .906 to .947. Overall, self-reported pain was more reliable than fcMRI data. These results highlight that fMRI findings might be less reliable than inherently assumed and have implications for future studies proposing pain markers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.