Evidence map›Paper›PMID 26371786›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2016

Sexual Behavior Patterns and PrEP Dosing Preferences in a Large Sample of North American Men Who Have Sex With Men.

Conor Stack, Catie Oldenburg, Matthew Mimiaga, Steven A Elsesser, Douglas Krakower, David S Novak, James E Egan, Ronald Stall, Steve Safren, Kenneth H Mayer

Abstract read
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Destination-Specific and Home Environment Condom Norms Influence Sexual Behavior During Travel.AIDS education and prevention : official publication of the International Society for AIDS Education · 2022
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. PrEP as a Lifestyle and Investment for Adolescent Girls and Young Women in Sub-Saharan Africa.Journal of the International Association of Providers of AIDS Care
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Conor Stack*Department of Medicine, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA;†Department of Epidemiology, Harvard School of Public Health, Boston, MA;‡Institute for Community Health Promotion, Brown University School of Public Health, Providence, RI;§The Fenway Institute, Fenway Health, Boston, MA;¶Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA;#On-Line Buddies, Cambridge, MA;**Department of Behavioral and Community Health Sciences, University of Pittsburgh, Pittsburgh, PA; and††Department of Psychology, University of Miami, Coral Gables, FL.
Catie Oldenburg
Matthew Mimiaga
Steven A Elsesser
Douglas Krakower
David S Novak
James E Egan
Ronald Stall
Steve Safren
Kenneth H Mayer

Funding

HIV and Other Infectious Consequences of Substance UseT32DA013911 · NIDA · MIRIAM HOSPITAL · PI TRACI C GREEN, JOSIAH D RICH · 2001 to 2026
$9.6M
The Brown Initiative in HIV and AIDS Clinical Research for Minority CommunitiesR25MH083620 · NIMH · MIRIAM HOSPITAL · PI NUNN, AMY STEWART · 2008 to 2025
$3.7M
Addressing psychosocial comorbidities in HIV treatment and preventionK24DA040489 · NIDA · UNIVERSITY OF MIAMI CORAL GABLES · PI SAFREN, STEVEN A · 2016 to 2020
$931k
Optimizing HIV Pre-Exposure Prophylaxis through Shared Decision MakingK23MH098795 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KRAKOWER, DOUGLAS SCOTT · 2012 to 2016
$873k
Addressing psychosocial comorbidities in HIV treatment and preventionK24MH094214 · NIMH · UNIVERSITY OF MIAMI CORAL GABLES · PI SAFREN, STEVEN A · 2011 to 2015
$858k
Feasibility of Short-Term PrEP Uptake for MSM with Episodic High-Risk for HIVR34MH104083 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI EGAN, JAMES ERIN, MAYER, KENNETH H · 2015 to 2017
$742k
NIAID NIH HHS P30 AI06354NIDA NIH HHS K24 DA040489NIDA NIH HHS T32 DA013911NIDA NIH HHS T32DA013911NIMH NIH HHS K23 MH098795NIMH NIH HHS K24 MH094214NIMH NIH HHS K24MH094214NIMH NIH HHS R25 MH083620NIMH NIH HHS R25MH083620NIMH NIH HHS R34 MH104083NIMH NIH HHS R34MH104083
6 · The paper itself

Abstract

introductionPre-exposure prophylaxis (PrEP), taken as a single daily coformulated pill containing tenofovir -emtricitabine, is a promising intervention to reduce the likelihood of HIV acquisition in at-risk individuals, including men who have sex with men. Little is known about the acceptability of less than daily, intermittent PrEP regimens.

methodsWe conducted an online survey of North American men who have sex with men to characterize their sexual frequency and planning behaviors and correlate these with PrEP dosing preferences.

resultsOf the 3217 respondents who completed the survey, 46% reported engaging in unplanned condomless anal intercourse (CAI) at least once in previous 3 months and 8% reported engaging in CAI more than once per week. In multivariable analysis, reporting unplanned CAI was associated with lower educational level, identifying as homosexual/gay as compared with bisexual, being in a monogamous relationship, having a higher self-perceived risk of HIV acquisition, reporting higher income, engaging in CAI more than five times in the last 3 months, and not having visited a health care provider in the previous year. Frequent CAI (>1 time per week) was associated with being younger, identifying as homosexual/gay as compared with bisexual, being in a monogamous relationship, and having a higher self-perceived risk of HIV. Having only planned sex over the last 3 months was associated with a preference for event-based PrEP, whereas having frequent or unplanned CAI was associated with a preference for daily or time-driven PrEP regimens, respectively.

conclusionOur findings suggest that preferences for different PrEP regimens are associated with the sexual frequency and planning behaviors of potential users.

Indexed as

Homosexuality, MaleAdultAnti-HIV AgentsEducational StatusHealth Knowledge, Attitudes, PracticeHIV InfectionsHumansMaleMiddle AgedMultivariate AnalysisPatient Acceptance of Health CarePre-Exposure ProphylaxisRisk FactorsSexual PartnersUnited StatesUnsafe SexAnti-HIV Agents

Identifiers

PMID26371786
PMCPMC4713279

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.