ArticleeLife2015
Abundant toxin-related genes in the genomes of beneficial symbionts from deep-sea hydrothermal vent mussels.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Taxonomy, tissue, and habitat influence mollusk microbial communities.The ISME journal · 2026Pooled it
- Host species-specific gene expression by a widespread and flexible chemosynthetic symbiont.The ISME journal · 2026Article
- Metabolically-versatile Ca. Thiodiazotropha symbionts of the deep-sea lucinid clamISME communications · 2024Article
- The genome of the deep-sea anemoneProceedings. Biological sciences · 2023Article
- A regulatory hydrogenase gene cluster observed in the thioautotrophic symbiont of Bathymodiolus mussel in the East Pacific Rise.Scientific reports · 2022Article
- Genome assembly of the chemosynthetic endosymbiont of the hydrothermal vent snail Alviniconcha adamantis from the Mariana Arc.G3 (Bethesda, Md.) · 2022Article
- Pangenome Evolution in Environmentally Transmitted Symbionts of Deep-Sea Mussels Is Governed by Vertical Inheritance.Genome biology and evolution · 2022Article
- A virulentVirulence · 2021Article
- Endozoicomonadaceae symbiont in gills of Acesta clam encodes genes for essential nutrients and polysaccharide degradation.FEMS microbiology ecology · 2021Article
- Article
- A Toll-like receptor identified inPeerJ · 2021Article
- Endosymbionts of Metazoans Dwelling in the PACManus Hydrothermal Vent: Diversity and Potential Adaptive Features Revealed by Genome Analysis.Applied and environmental microbiology · 2020Article
- Evidence of Vent-Adaptation in Sponges Living at the Periphery of Hydrothermal Vent Environments: Ecological and Evolutionary Implications.Frontiers in microbiology · 2020Article
- Identification and characterization of endosymbiosis-related immune genes in deep-sea musselsJournal of oceanology and limnology · 2020Article
- Functional diversity enables multiple symbiont strains to coexist in deep-sea mussels.Nature microbiology · 2019Article
- Article
- The microbiomes of deep-sea hydrothermal vents: distributed globally, shaped locally.Nature reviews. Microbiology · 2019Review
- Article
- Endosymbiont genomes yield clues of tubeworm success.The ISME journal · 2018Article
- Article
Corrections and comments
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Authors and funding
18 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bathymodiolus mussels live in symbiosis with intracellular sulfur-oxidizing (SOX) bacteria that provide them with nutrition. We sequenced the SOX symbiont genomes from two Bathymodiolus species. Comparison of these symbiont genomes with those of their closest relatives revealed that the symbionts have undergone genome rearrangements, and up to 35% of their genes may have been acquired by horizontal gene transfer. Many of the genes specific to the symbionts were homologs of virulence genes. We discovered an abundant and diverse array of genes similar to insecticidal toxins of nematode and aphid symbionts, and toxins of pathogens such as Yersinia and Vibrio. Transcriptomics and proteomics revealed that the SOX symbionts express the toxin-related genes (TRGs) in their hosts. We hypothesize that the symbionts use these TRGs in beneficial interactions with their host, including protection against parasites. This would explain why a mutualistic symbiont would contain such a remarkable 'arsenal' of TRGs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.