ArticleSchizophrenia bulletin2016
Age at First Episode Modulates Diagnosis-Related Structural Brain Abnormalities in Psychosis.
Article in Schizophrenia bulletin, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03951376 (Universal Preventive Resilience Intervention Globally Implemented in Schools to Improve and Promote Mental Health for Teenagers), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Universal Preventive Resilience Intervention Globally Implemented in Schools to Improve and Promote Mental Health for Teenagers
Who cites it
22 citing papers in PubMed, 64 citations in OpenAlex.
- Polygenic profiles in youth with early-onset psychosis and offspring of schizophrenia or bipolar disorder patients.European child & adolescent psychiatry · 2026Article
- Obstetric complications, cortical gyrification, and cognition in first-episode psychosis.Psychological medicine · 2025Article
- Understanding Pediatric Bipolar Disorder Through the Investigation of Clinical, Neuroanatomic, Neurophysiological and Neurocognitive Dimensions: A Pilot Study.Brain sciences · 2025Article
- Age-related change in cortical thickness in adolescents at clinical high risk for psychosis: a longitudinal study.European child & adolescent psychiatry · 2024Article
- Neuroanatomical Correlates of the Late Positive Potential in Youth with Pediatric Bipolar Disorder.Current neuropharmacology · 2023Article
- Combining MRI and clinical data to detect high relapse risk after the first episode of psychosis.Schizophrenia (Heidelberg, Germany) · 2022Article
- Longitudinal Allometry of Sulcal Morphology in Health and Schizophrenia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Cortical thinning over two years after first-episode psychosis depends on age of onset.Schizophrenia (Heidelberg, Germany) · 2022Article
- Cortical and Subcortical Structural Morphometric Profiles in Individuals with Nonaffective and Affective Early Illness Psychosis.Schizophrenia bulletin open · 2022Article
- Fronto-Parietal Gray Matter Volume Loss Is Associated with Decreased Working Memory Performance in Adolescents with a First Episode of Psychosis.Journal of clinical medicine · 2021Article
- Changes in Brain Structure, Function, and Network Properties in Patients With First-Episode Schizophrenia Treated With Antipsychotics.Frontiers in psychiatry · 2021Article
- A Real-World Observation of Antipsychotic Effects on Brain Volumes and Intrinsic Brain Activity in Schizophrenia.Frontiers in neuroscience · 2021Article
- Cortical Correlates of Impulsive Aggressive Behavior in Pediatric Bipolar Disorder.Frontiers in psychiatry · 2021Article
- Elevated Extracellular Free-Water in a Multicentric First-Episode Psychosis Sample, Decrease During the First 2 Years of Illness.Schizophrenia bulletin · 2020Article
- Structural Associations of Cortical Contrast and Thickness in First Episode Psychosis.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- UPRIGHT, a resilience-based intervention to promote mental well-being in schools: study rationale and methodology for a European randomized controlled trial.BMC public health · 2019Article
- Differences in the regulation of inflammatory pathways in adolescent- and adult-onset first-episode psychosis.European child & adolescent psychiatry · 2019Article
- Cingulate abnormalities in bipolar disorder relate to gender and outcome: a region-based morphometry study [corrected].European archives of psychiatry and clinical neuroscience · 2019Article
- Neutrophil Count Is Associated With Reduced Gray Matter and Enlarged Ventricles in First-Episode Psychosis.Schizophrenia bulletin · 2019Article
- Dysregulated Maturation of the Functional Connectome in Antipsychotic-Naïve, First-Episode Patients With Adolescent-Onset Schizophrenia.Schizophrenia bulletin · 2019Article
Corrections and comments
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Authors and funding
16 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain volume and thickness abnormalities have been reported in first-episode psychosis (FEP). However, it is unclear if and how they are modulated by brain developmental stage (and, therefore, by age at FEP as a proxy). This is a multicenter cross-sectional case-control brain magnetic resonance imaging (MRI) study. Patients with FEP (n = 196), 65.3% males, with a wide age at FEP span (12-35 y), and healthy controls (HC) (n = 157), matched for age, sex, and handedness, were scanned at 6 sites. Gray matter volume and thickness measurements were generated for several brain regions using FreeSurfer software. The nonlinear relationship between age at scan (a proxy for age at FEP in patients) and volume and thickness measurements was explored in patients with schizophrenia spectrum disorders (SSD), affective psychoses (AFP), and HC. Earlier SSD cases (ie, FEP before 15-20 y) showed significant volume and thickness deficits in frontal lobe, volume deficits in temporal lobe, and volume enlargements in ventricular system and basal ganglia. First-episode AFP patients had smaller cingulate cortex volume and thicker temporal cortex only at early age at FEP (before 18-20 y). The AFP group also had age-constant (12-35-y age span) volume enlargements in the frontal and parietal lobe. Our study suggests that age at first episode modulates the structural brain abnormalities found in FEP patients in a nonlinear and diagnosis-dependent manner. Future MRI studies should take these results into account when interpreting samples with different ages at onset and diagnosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.