ArticleJournal of immunology (Baltimore, Md. : 1950)2015
Cutting Edge: Resident Memory CD8 T Cells Express High-Affinity TCRs.
Article in Journal of immunology (Baltimore, Md. : 1950), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 74 citations in OpenAlex.
- PD-1⁺ CD8⁺ T cells: roles of PD-1 beyond an exhaustion marker.Seminars in immunopathology · 2026Review
- Origins of CD8 tissue resident memory.Frontiers in immunology · 2026Review
- Keeping it local: how CD8 TRMs regulate viral and cancer immunity.Frontiers in immunology · 2025Review
- CD8+ Tissue-Resident Memory T Cells: Versatile Guardians of the Tissue.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Location versus ID: what matters to lung-resident memory T cells?Frontiers in immunology · 2024Article
- Polyomavirus Wakes Up and Chooses Neurovirulence.Viruses · 2023Review
- Tumor resident memory CD8 T cells and concomitant tumor immunity develop independently of CD4 help.Scientific reports · 2023Article
- Keeping T cell memories in mind.Trends in immunology · 2022Review
- Tissue-resident memory T cells in the kidney.Seminars in immunopathology · 2022Review
- Human T lymphocytes at tumor sites.Seminars in immunopathology · 2022Review
- Influenza-Induced CD103ImmunoHorizons · 2022Article
- The evolving role of tissue-resident memory T cells in infections and cancer.Science advances · 2022Review
- The perception and response of T cells to a changing environment are based on the law of initial value.Science signaling · 2022Review
- Tissue-resident memory T cells in chronic liver diseases: Phenotype, development and function.Frontiers in immunology · 2022Review
- Memory CD8Immunology · 2021Article
- Decoding Tissue-Residency: Programming and Potential of Frontline Memory T Cells.Cold Spring Harbor perspectives in biology · 2021Review
- Formation of Tissue-Resident CD8Cold Spring Harbor perspectives in biology · 2021Review
- Area under Immunosurveillance: Dedicated Roles of Memory CD8 T-Cell Subsets.Cold Spring Harbor perspectives in biology · 2020Review
- Relationship of 2D Affinity to T Cell Functional Outcomes.International journal of molecular sciences · 2020Review
- A committed tissue-resident memory T cell precursor within the circulating CD8+ effector T cell pool.The Journal of experimental medicine · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Tissue-resident memory T (TRM) cells serve as vanguards of antimicrobial host defense in nonlymphoid tissues, particularly at barrier epithelia and in organs with nonrenewable cell types (e.g., brain). In this study, we asked whether an augmented ability to sense Ag complemented their role as early alarms of pathogen invasion. Using mouse polyomavirus, we show that brain-resident mouse polyomavirus-specific CD8 T cells, unlike memory cells in the spleen, progressively increase binding to MHC class I tetramers and CD8 coreceptor expression. Using the two-dimensional micropipette adhesion-frequency assay, we show that TRM cells in brain, as well as in kidney, express TCRs with up to 20-fold higher affinity than do splenic memory T cells, whereas effector cells express TCRs of similar high affinity in all organs. Together, these data demonstrate that TRM cells retain high TCR affinity, which endows them with the high Ag sensitivity needed for front-line defense against infectious agents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.