Evidence map›Paper›PMID 26371188›Full record

ArticleThe Journal of experimental medicine2015

The microRNA-212/132 cluster regulates B cell development by targeting Sox4.

Arnav Mehta, Mati Mann, Jimmy L Zhao, Georgi K Marinov, Devdoot Majumdar, Yvette Garcia-Flores, Xiaomi Du, Erdem Erikci, Kamal Chowdhury, David Baltimore

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.

  1. Pooled it
  2. B cells in cancer: functions, mechanisms and therapeutic advances.Signal transduction and targeted therapy · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Arnav MehtaDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125 David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095.
Mati MannDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Jimmy L ZhaoDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125 David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095.
Georgi K MarinovDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Devdoot MajumdarDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Yvette Garcia-FloresDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Xiaomi DuDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Erdem ErikciDepartment of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Gottingen 37077, Germany.
Kamal ChowdhuryDepartment of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Gottingen 37077, Germany.
David BaltimoreDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125 baltimo@caltech.edu.
California Institute of Technology · USMax Planck Institute for Biophysical Chemistry · DEUniversity of California, Los Angeles · US

Funding

UCLA-Caltech Medical Scientist Training ProgramT32GM008042 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A, DAWSON, DAVID WAYNE · 1985 to 2023
$29.9M
MicroRNA Function in the Immune SystemR01AI079243 · NIAID · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI BALTIMORE, DAVID · 2008 to 2018
$4.1M
Investigate the function of miR-146a in myeloid developmentF30HL110691 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHAO, JIMMY LIU · 2011 to 2014
$185k
MicroRNA-125b physiologically and pathologically regulates myelopoiesis through IF30CA183220 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MEHTA, ARNAV · 2014 to 2015
$82k
NCI NIH HHS CA183220NCI NIH HHS F30 CA183220NHLBI NIH HHS F30 HL110691NHLBI NIH HHS HL110691NIAID NIH HHS R01 AI079243NIAID NIH HHS R01AI079243NIGMS NIH HHS T32 GM008042
6 · The paper itself

Abstract

MicroRNAs have emerged as key regulators of B cell fate decisions and immune function. Deregulation of several microRNAs in B cells leads to the development of autoimmune disease and cancer in mice. We demonstrate that the microRNA-212/132 cluster (miR-212/132) is induced in B cells in response to B cell receptor signaling. Enforced expression of miR-132 results in a block in early B cell development at the prepro-B cell to pro-B cell transition and induces apoptosis in primary bone marrow B cells. Importantly, loss of miR-212/132 results in accelerated B cell recovery after antibody-mediated B cell depletion. We find that Sox4 is a target of miR-132 in B cells. Co-expression of SOX4 with miR-132 rescues the defect in B cell development from overexpression of miR-132 alone, thus suggesting that miR-132 may regulate B lymphopoiesis through Sox4. In addition, we show that the expression of miR-132 can inhibit cancer development in cells that are prone to B cell cancers, such as B cells expressing the c-Myc oncogene. We have thus uncovered miR-132 as a novel contributor to B cell development.

Indexed as

3' Untranslated RegionsAnimalsApoptosisB-LymphocytesCell SurvivalGene Expression RegulationHEK293 CellsHumansLeukemia, B-CellLeukemia, ExperimentalMice, Inbred C57BLMice, KnockoutMicroRNAsMultigene FamilySOXC Transcription Factors3' Untranslated RegionsMicroRNAsMIRN132 microRNA, mouseMIRN212 microRNA, mouseSox4 protein, mouseSOXC Transcription Factors

Identifiers

PMID26371188
PMCPMC4577845
OpenAlexW2270595368

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.