Evidence map›Paper›PMID 26371171›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2015

Central-peripheral neural network interactions evoked by vagus nerve stimulation: functional consequences on control of cardiac function.

Jeffrey L Ardell, Pradeep S Rajendran, Heath A Nier, Bruce H KenKnight, J Andrew Armour

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 148 citations in OpenAlex.

  1. Trial
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  3. Autonomic Neuromodulation Acutely Ameliorates Left Ventricular Strain in Humans.Journal of cardiovascular translational research · 2019
    Trial
  4. Timing Considerations for Noninvasive Vagal Nerve Stimulation in Clinical Studies.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2019
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  5. Trial
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  11. Single-Electrode, Bidirectional Control of Heart Rate via Vagus Nerve Modulation in Rat Model.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026
    Article
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34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jeffrey L ArdellNeurocardiology Research Center of Excellence, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California; Cardiac Arrhythmia Center, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California; Molecular, Cellular, and Integrative Physiology Program, University of California-Los Angeles, Los Angeles, California; jardell@mednet.ucla.edu.
Pradeep S RajendranNeurocardiology Research Center of Excellence, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California; Cardiac Arrhythmia Center, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California; Molecular, Cellular, and Integrative Physiology Program, University of California-Los Angeles, Los Angeles, California;
Heath A NierDepartment of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee; and.
Bruce H KenKnightCyberonics Inc., Houston, Texas.
J Andrew ArmourNeurocardiology Research Center of Excellence, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California; Cardiac Arrhythmia Center, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California;
University of California, Los Angeles · USEast Tennessee State University · US

Funding

Myocardial Ischemia Remodels the Cardiac Nervous SystemR01HL071830 · NHLBI · EAST TENNESSEE STATE UNIVERSITY · PI ARDELL, JEFFREY L · 2005 to 2013
$2.8M
Training in Molecular, Cellular &Integrative PhysiologyT32GM065823 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TIDBALL, JAMES G · 2003 to 2017
$2.1M
Myocardial infarction alters information processing within the intrinsic cardiac nervous systemF31HL127974 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAJENDRAN, PRADEEP SUNDARAM · 2015 to 2017
$72k
NHLBI NIH HHS F31 HL127974NHLBI NIH HHS HL-71830NIGMS NIH HHS 2T32 GM-065823
6 · The paper itself

Abstract

Using vagus nerve stimulation (VNS), we sought to determine the contribution of vagal afferents to efferent control of cardiac function. In anesthetized dogs, the right and left cervical vagosympathetic trunks were stimulated in the intact state, following ipsilateral or contralateral vagus nerve transection (VNTx), and then following bilateral VNTx. Stimulations were performed at currents from 0.25 to 4.0 mA, frequencies from 2 to 30 Hz, and a 500-μs pulse width. Right or left VNS evoked significantly greater current- and frequency-dependent suppression of chronotropic, inotropic, and lusitropic function subsequent to sequential VNTx. Bradycardia threshold was defined as the current first required for a 5% decrease in heart rate. The threshold for the right vs. left vagus-induced bradycardia in the intact state (2.91 ± 0.18 and 3.47 ± 0.20 mA, respectively) decreased significantly with right VNTx (1.69 ± 0.17 mA for right and 3.04 ± 0.27 mA for left) and decreased further following bilateral VNTx (1.29 ± 0.16 mA for right and 1.74 ± 0.19 mA for left). Similar effects were observed following left VNTx. The thresholds for afferent-mediated effects on cardiac parameters were 0.62 ± 0.04 and 0.65 ± 0.06 mA with right and left VNS, respectively, and were reflected primarily as augmentation. Afferent-mediated tachycardias were maintained following β-blockade but were eliminated by VNTx. The increased effectiveness and decrease in bradycardia threshold with sequential VNTx suggest that 1) vagal afferents inhibit centrally mediated parasympathetic efferent outflow and 2) the ipsilateral and contralateral vagi exert a substantial buffering capacity. The intact threshold reflects the interaction between multiple levels of the cardiac neural hierarchy.

Indexed as

Vagus Nerve StimulationAfferent PathwaysAnimalsBradycardiaDogsEfferent PathwaysFemaleHeartHeart RateMaleParasympathetic Nervous SystemSympathetic Nervous SystemTachycardiaVagus Nerveafferentautonomic nervous systemintrinsic cardiac nervous systemparasympatheticvagus nerve stimulation

Identifiers

PMID26371171
PMCPMC4666982
OpenAlexW2175257784

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.